Results 61 to 70 of about 37,805 (220)

CD39 abrogates platelet-derived factors induced IL-1β expression in the human placenta

Frontiers in Cell and Developmental Biology, 2023
Tissue insults in response to inflammation, hypoxia and ischemia are accompanied by the release of ATP into the extracellular space. There, ATP modulates several pathological processes, including chemotaxis, inflammasome induction and platelet activation.
Désirée Forstner, Jacqueline Guettler, Beatrice A. Brugger, Freya Lyssy, Lena Neuper, Christine Daxboeck, Gerhard Cvirn, Julia Fuchs, Kristin Kraeker, Kristin Kraeker, Alina Frolova, Alina Frolova, Alina Frolova, Daniela S. Valdes, Daniela S. Valdes, Christina Stern, Birgit Hirschmugl, Herbert Fluhr, Christian Wadsack, Berthold Huppertz, Olivia Nonn, Olivia Nonn, Florian Herse, Florian Herse, Martin Gauster   +24 more
doaj   +1 more source

Ci8 short, a novel LPS-induced peptide from the ascidian Ciona intestinalis,modulates responses of the human immune system [PDF]

, 2018
The selective modulation of immunity is an emerging concept driven by the vast advances in our understanding of this crucial host defense system. Invertebrates have raised researchers’ interest as potential sources of new bioactive molecules owing to ...
Bonura Angela, Colombo Paolo, Gervasi Francesco, Longo Alessandra, Melis M. R., Schildberg F. A., Vizzini Aiti, Vlaha Sara   +7 more
core   +1 more source

Nucleotide Analog ARL67156 as a Lead Structure for the Development of CD39 and Dual CD39/CD73 Ectonucleotidase Inhibitors [PDF]

Frontiers in Pharmacology, 2020
Nucleoside triphosphate diphosphohydrolase1 (NTPDase1, CD39) inhibitors have potential as novel drugs for the (immuno)therapy of cancer. They increase the extracellular concentration of immunostimulatory ATP and reduce the formation of AMP, which can be further hydrolyzed by ecto-5'-nucleotidase (CD73) to immunosuppressive, cancer-promoting adenosine ...
Laura Schäkel, Constanze C. Schmies, Riham M. Idris, Xihuan Luo, Sang-Yong Lee, Vittoria Lopez, Salahuddin Mirza, The Hung Vu, Julie Pelletier, Jean Sévigny, Jean Sévigny, Vigneshwaran Namasivayam, Christa E. Müller   +12 more
openaire   +3 more sources

IL‐2 Free Expansion of T Cells with Immunofilaments

Advanced Healthcare Materials, EarlyView.
Ratio and density of stimulatory αCD3 and αCD28 mAb on immunofilaments (IF) influence T cell expansion, cytokine production, and effector phenotype. Moreover, IL‐2 supplementation is not necessary with optimal performing IFs, which leads to simpler culture conditions, and negative side effects of IL‐2 supplementation are reduced.
Marjolein Schluck, Lea Weiss, René Classens, Carl G. Figdor, Roel Hammink   +4 more
wiley   +1 more source

Expression of CD39 Is Correlated With HIV DNA Levels in Naïve Tregs in Chronically Infected ART Naïve Patients

Frontiers in Immunology, 2019
Background: Treg cells represent important viral reservoirs during chronic HIV infection. CD39 is closely involved in Treg-mediated immunosuppressive effects. However, CD39 expression on nTregs and mTregs and a relationship with HIV DNA levels during HIV
Jin-Wen Song, Hui-Huang Huang, Chao Zhang, Hong-Ge Yang, Ji-Yuan Zhang, Ruo-Nan Xu, Lei Jin, Ming Shi, Fu-Sheng Wang, Yan-Mei Jiao   +9 more
doaj   +1 more source

Altered CD39 and CD73 Expression in Rheumatoid Arthritis: Implications for Disease Activity and Treatment Response

Biomolecules, 2023
In rheumatoid arthritis (RA) synovium, ATP, and ADP are released, sparking inflammation. Ectoenzymes CD39 and CD73 metabolize these purine nucleotides, generating anti-inflammatory adenosine. Therefore, dysregulated CD39 and CD73 expression may impact RA
María Angels Ortiz, Cesar Diaz-Torné, Juan Jose De Agustin, Paula Estrada, Delia Reina, María Victoria Hernandez, Hye Sang, Carlos Zamora, Elisabet Cantó, Hector Corominas, Silvia Vidal   +10 more
doaj   +1 more source

Evaluation of the effect of GM-CSF blocking on the phenotype and function of human monocytes [PDF]

, 2020
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multipotent cytokine that prompts the proliferation of bone marrow-derived macrophages and granulocytes.
Esmaeil, Nafiseh, Lotfi, Noushin, Rostami, Mohamad, Zhang, Guang-Xian   +3 more
core   +2 more sources

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

High circulating CD39+ regulatory T cells predict poor survival for sepsis patients

International Journal of Infectious Diseases, 2015
Background: Sepsis encompasses two phases, the ‘hyper’-reactive phase and the ‘hypo’-reactive phase. The initial inflammatory stage is quickly counterbalanced by an anti-inflammatory response, which compromises the immune system, leading to immune ...
Huihuang Huang, Ruonan Xu, Fang Lin, Chunmei Bao, Siyu Wang, Chengcheng Ji, Ke Li, Lei Jin, Jingsong Mu, Yonggang Wang, Lei Li, Lijian Sun, Biao Xu, Zheng Zhang, Fu-Sheng Wang   +14 more
doaj   +1 more source

Immunoregulatory Potential of Exosomes Derived from Cancer Stem Cells. [PDF]

, 2020
Head and neck squamous cell carcinomas (HNSCCs) are malignancies that originate in the mucosal lining of the upper aerodigestive tract. Despite advances in therapeutic interventions, survival rates among HNSCC patients have remained static for years ...
Abouyared, Marianne, Anderson, Johnathon D, Archard, Joehleen A, Belafsky, Peter C, Beliveau, Angela, Bewley, Arnaud F, Birkeland, Andrew, Clayton, Shannon M, Farwell, D Gregory, Rao, Shyam, Wagner, Joseph   +10 more
core   +1 more source