Results 91 to 100 of about 36,599 (239)
In Situ Assembly of Transformable Monopeptide on Activated Neutrophils Attenuates NETs‐Induced Hepatocellular Carcinoma Metastasis by Disrupting NE Nuclear Translocation
Advanced Science, EarlyView.Activated neutrophils release extracellular traps (NETs) that promote tumor metastasis. FTP‐NPs are develpoed, a peptidic nanomaterial that binds NE on neutrophil membranes, forming NE‐fibril clusters that deactivate NE and prevent NETs formation. This strategy reduces metastasis and enhances the anti‐tumor immune response by targeting NE subcellular ...Yichi Chen, Yijun Wang, Haitao Shang, Jiayue Qiu, Ruotian Zhang, Yuxiang Xiong, Tong Wang, Fengyi Wang, Anbang Wu, Xin Lin, Bolin Wu, Chen Huang, Wen Cheng, Lu Zhang +13 morewiley +1 more sourceHepatitis C virus infection and related liver disease: the quest for the best animal model [PDF]
, 2013 Hepatitis C virus (HCV) is a major cause of cirrhosis and hepatocellular carcinoma (HCC) making the virus the most common cause of liver failure and transplantation.Baumert, Thomas F, Mailly, Laurent, Meuleman, Philip, Robinet, Eric, Zeisel, Mirjam +4 morecore +3 more sourcesNanozymes for Non‐Neoplastic Diseases: Catalytic Therapy Redefined
Aggregate, EarlyView.Non‐neoplastic diseases pose a significant health burden. Nanozymes, enzyme‐like nanomaterials, offer promising strategies for regulating oxidative stress and inflammation. This review explores their development, structure–function relationships, and therapeutic potential, with a focus on precision medicine through targeted delivery and multimodal ...Ling Mei, Xikai Wang, Zhuang Hu, Jierui Yan, Xiaobo Wang, Haoran Wang, Ya Hou, Pengfei Zhang, Qihang Ding +8 morewiley +1 more sourceCombined prognostic value of the cancer stem cell markers CD47 and CD133 in esophageal squamous cell carcinoma
Cancer Medicine, 2019 Background Treatments based on the inhibition of pivotal signals of cancer stem cells (CSCs) are on a promising track. Recent studies have shown that targeting CSCs with broader immune‐based therapeutic methods, for example, the anti‐CD47 treatment, may ...Jian‐Hua Wang, Shu‐Ting Huang, Lan Zhang, Zi‐Gang Liu, Rong‐Xin Liang, Sen‐Wei Jiang, Yi‐Nan Jiang, Xing‐Juan Yu, Yu‐Chuan Jiang, Xi‐Zhao Li, Pei‐Fen Zhang, Zhe‐Sheng Wen, Min Zheng +12 moredoaj +1 more sourceProtein S Enhances the Phagocytosis of Phosphatidylserine‐Exposing Erythrocytes: Implications in Sickle Cell Disease
American Journal of Hematology, EarlyView.ABSTRACT
The major anticoagulant Protein S (PROS1) also contributes to the phagocytosis of apoptotic cells by bridging exposed phosphatidylserine (PtdSer) to the MerTK receptor on macrophages (efferocytosis). Whether PROS1 is involved in the splenic clearance of PtdSer‐positive senescent and altered erythrocytes such as erythrocyte ghosts (eryghosts ...Claire Auditeau, Aurélie Fricot, Raphaël Gauthier, Abdoulaye Sissoko, Zeynep Cacan, Céline Gounou, Laure Joseph, Sandra Manceau, Slimane Allali, Michael Dussiot, Mickael Marin, Alexis Lavergne, Mariem Khamari, Sophie Moog, Elsa Bianchini, Laetitia Claer, Sandrine Laurance, Valentine Brousse, Sébastien Eymieux, Philippe Roingeard, Pascal Amireault, Thiago Trovati Maciel, Alain Brisson, Pierre Buffet, François Saller, Delphine Borgel, Camille Roussel +26 morewiley +1 more sourceChanges in renal medulla gene expression in a pre-clinical model of post cardiopulmonary bypass acute kidney injury [PDF]
, 2014 BACKGROUND: Acute kidney injury (AKI) is a common and serious complication of cardiac surgery using cardiopulmonary bypass (CPB). The pathogenesis is poorly understood and the study of AKI in rodent models has not led to improvements in clinical outcomes.Angelini, Gianni D, Caputo, Massimo, Ghorbel, Mohamed, Murphy, Gavin, Patel, Nishith, Sheikh, Maimuna +5 morecore +2 more sourcesEstablishment and molecular profiling of a PDX model of a metachronous brain tumor in a patient with constitutional mismatch repair deficiency with biallelic MSH6 variant
Animal Models and Experimental Medicine, EarlyView.A 6½‐year‐old girl was diagnosed with a medulloblastoma, SHH activated, subtype 3 and TP53 mutant (somatic). After surgery and chemotherapy, she was monitored with quarterly magnetic resonance imaging (MRI) scans and remained free of disease for almost 4 years.Daniel Antunes Moreno, Bruna Minniti Mançano, Mirella Baroni, Eric Allison Philot, Felipe Antonio de Oliveira Garcia, Murilo Bonatelli, Flávia Escremim de Paula, Iara Viana Vidigal Santana, Gustavo Ramos Teixeira, Mauricio Yamanari, Luciane Sussuchi da Silva, André Escremim de Paula, Augusto Perazzolo Antoniazzi, Adrian Willig, Xiaobin Xing, Zhenyu Xu, Lucas Lourenço, Carlos Almeida Junior, Silvia Aparecida Teixeira, Rui Manuel Reis +19 morewiley +1 more sourceA principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape [PDF]
, 2016 This is the final version of the article. Available from the publisher via the DOI in this record.Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time.Abecasis, GR, Ahluwalia, TS, Albrecht, E, Bakker, SJL, Barlassina, C, Bartz, TM, Beilby, J, Bellis, C, Bergman, RN, Bergmann, S, Blangero, J, Blüher, M, Boehnke, M, Boerwinkle, E, Bonnycastle, LL, Boomsma, DI, Borecki, IB, Bornstein, SR, Bouchard, C, Bragg-Gresham, JL, Bruinenberg, M, Cadby, G, Campbell, H, Carola Zillikens, M, Chambers, JC, Chasman, DI, Chen, Y-DI, Chiang, CWK, Chines, PS, Chu, AY, Collins, FS, Couto Alves, A, Cucca, F, Cupples, LA, Cusi, D, D'Avila, F, de Geus, EJC, Dedoussis, G, Deloukas, P, Dimitriou, M, Döring, A, Eklund, N, Eriksson, J, Eriksson, JG, Esko, T, Farmaki, A-E, Farrall, M, Feitosa, MF, Ferreira, T, Fischer, K, Forouhi, NG, Fox, C, Frayling, T, Friedrich, N, Gansevoort, RT, Gieger, C, Gjesing, AP, Glorioso, N, Goel, A, Gorski, M, Graff, M, Grallert, H, Grarup, N, Grewal, J, Groop, LC, Gräßler, J, Hamsten, A, Hansen, T, Harder, MN, Hartman, CA, Hassinen, M, Hastie, N, Hattersley, AT, Havulinna, AS, Hayward, C, Heard-Costa, NL, Heid, IM, Heliövaara, M, Hicks, AA, Hillege, H, Hirschhorn, JN, Hofman, A, Holmen, O, Homuth, G, Hottenga, J-J, Hu, F, Hua Zhao, J, Huffman, JE, Hui, J, Hunter, DJ, Husemoen, LL, Hveem, K, Hysi, PG, Isaacs, A, Ittermann, T, Jackson, AU, Jalilzadeh, S, James, AL, Jarvelin, M-R, Jeff M, J, Jokinen, E, Jousilahti, P, Ju Sung, Y, Jula, A, Justice, AE, Jørgensen, T, Kajantie, E, Kanoni, S, Kaplan, RC, Karaleftheri, M, Keinanen-Kiukaanniemi, SM, Kinnunen, L, Knekt, PB, Koistinen, HA, Kolcic, I, Kooner, IK, Kooner, JS, Koskinen, S, Kovacs, P, Kristiansson, K, Kuh, D, Kutalik, Z, Kuusisto, J, Kyriakou, T, Kähönen, M, Laakso, M, Lahti, J, Laitinen, T, Lakka, TA, Langenberg, C, Leach, IM, Lehtimäki, T, Lewin, AM, Lichtner, P, Lindgren, CM, Lindström, J, Linneberg, A, Loos, RJF, Lorbeer, R, Lorentzon, M, Luan, J, Luben, R, Lyssenko, V, Mahajan, A, Mangino, M, Manunta, P, Marie Justesen, J, McArdle, WL, McCarthy, MI, Mcknight, B, Medina-Gomez, C, Metspalu, A, Mihailov, E, Milani, L, Mills, R, Mohlke, KL, Monda, KL, Montasser, ME, Morris, AP, Musk, AW, Mägi, R, Männistö, S, Müller, G, Müller-Nurasyid, M, Narisu, N, Njølstad, I, Nolte, IM, North, KE, O'Connell, JR, Ohlsson, C, Oldehinkel, AJ, Ong, KK, Oostra, BA, Osmond, C, Palmer, LJ, Palotie, A, Pankow, JS, Paternoster, L, Pedersen, O, Penninx, BW, Perola, M, Peters, A, Pichler, I, Pilia, MG, Polašek, O, Pramstaller, PP, Prokopenko, I, Psaty, BM, Puolijoki, H, Pérusse, L, Qi, L, Raitakari, OT, Rankinen, T, Rao, DC, Rauramaa, R, Rayner, NW, Ribel-Madsen, R, Rice, TK, Richards, M, Ridker, PM, Ried, JS, Rivadeneira, F, Rose, LM, Rudan, I, Ryan, KA, Salomaa, V, Salvi, E, Sanna, S, Sarzynski, MA, Schlessinger, D, Scholtens, S, Schwarz, PEH, Scott, RA, Sebert, S, Shudiner, AR, Smit, JH, Smith, MT, Snieder, H, Southam, L, Sparsø, TH, Spector, TD, Stančáková, A, Stefansson, K, Steinthorsdottir, V, Stirrups, K, Stolk, RP, Strachan, DP, Strauch, K, Stringham, HM, Stumvoll, M, Swertz, MA, Swift, AJ, Sørensen, TIA, Tachmazidou, I, Tee Khaw, K, Teumer, A, Thorleifsson, G, Thorsteinsdottir, U, Tremblay, A, Tsafantakis, E, Tuomilehto, J, Tönjes, A, Uitterlinden, AG, Uusitupa, M, van der Harst, P, van der Most, PJ, van Dongen, J, van Duijn, CM, Van Vliet-Ostaptchouk, JV, Vandenput, L, Vartiainen, E, Venturini, C, Verweij, N, Viikari, JS, Vitart, V, Vohl, M-C, Vollenweider, P, Vonk, JM, Völker, U, Waeber, G, Walker, RW, Wang, SR, Wareham, NJ, Watkins, H, Widén, E, Wild, SH, Willems, SM, Willemsen, G, Wilsgaard, T, Wilson, JF, Winkler, TW, Wong, A, Wright, AF, Yerges-Armstrong, LM, Zeggini, E, Zhang, W +275 morecore +28 more sourcesNanobiotechnology‐Based Approaches for Targeted Glioma Therapy
Advanced NanoBiomed Research, EarlyView.Nanoparticle systems cross the blood–brain barrier to deliver drugs precisely to glioma cells. Lipid, polymeric, and magnetic carriers enable controlled release, tumor targeting, and microenvironment modulation. These nanoplatforms enhance chemotherapy, radiotherapy, and immunotherapy, improving therapeutic efficacy while reducing systemic toxicity ...Jinwei Li, Yibo He, Yang Zhang, Lining Arnold Ju, Yao Wang, Jianxuan Zhou, Yinying Chai, Xuhui Hui, ShiYuan Tong, Si Zhang, Yanli Tan, Yinyan Wang +11 morewiley +1 more source
