Results 91 to 100 of about 38,316 (246)

A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape [PDF]

, 2016
This is the final version of the article. Available from the publisher via the DOI in this record.Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time.
Abecasis, GR, Ahluwalia, TS, Albrecht, E, Bakker, SJL, Barlassina, C, Bartz, TM, Beilby, J, Bellis, C, Bergman, RN, Bergmann, S, Blangero, J, Blüher, M, Boehnke, M, Boerwinkle, E, Bonnycastle, LL, Boomsma, DI, Borecki, IB, Bornstein, SR, Bouchard, C, Bragg-Gresham, JL, Bruinenberg, M, Cadby, G, Campbell, H, Carola Zillikens, M, Chambers, JC, Chasman, DI, Chen, Y-DI, Chiang, CWK, Chines, PS, Chu, AY, Collins, FS, Couto Alves, A, Cucca, F, Cupples, LA, Cusi, D, D'Avila, F, de Geus, EJC, Dedoussis, G, Deloukas, P, Dimitriou, M, Döring, A, Eklund, N, Eriksson, J, Eriksson, JG, Esko, T, Farmaki, A-E, Farrall, M, Feitosa, MF, Ferreira, T, Fischer, K, Forouhi, NG, Fox, C, Frayling, T, Friedrich, N, Gansevoort, RT, Gieger, C, Gjesing, AP, Glorioso, N, Goel, A, Gorski, M, Graff, M, Grallert, H, Grarup, N, Grewal, J, Groop, LC, Gräßler, J, Hamsten, A, Hansen, T, Harder, MN, Hartman, CA, Hassinen, M, Hastie, N, Hattersley, AT, Havulinna, AS, Hayward, C, Heard-Costa, NL, Heid, IM, Heliövaara, M, Hicks, AA, Hillege, H, Hirschhorn, JN, Hofman, A, Holmen, O, Homuth, G, Hottenga, J-J, Hu, F, Hua Zhao, J, Huffman, JE, Hui, J, Hunter, DJ, Husemoen, LL, Hveem, K, Hysi, PG, Isaacs, A, Ittermann, T, Jackson, AU, Jalilzadeh, S, James, AL, Jarvelin, M-R, Jeff M, J, Jokinen, E, Jousilahti, P, Ju Sung, Y, Jula, A, Justice, AE, Jørgensen, T, Kajantie, E, Kanoni, S, Kaplan, RC, Karaleftheri, M, Keinanen-Kiukaanniemi, SM, Kinnunen, L, Knekt, PB, Koistinen, HA, Kolcic, I, Kooner, IK, Kooner, JS, Koskinen, S, Kovacs, P, Kristiansson, K, Kuh, D, Kutalik, Z, Kuusisto, J, Kyriakou, T, Kähönen, M, Laakso, M, Lahti, J, Laitinen, T, Lakka, TA, Langenberg, C, Leach, IM, Lehtimäki, T, Lewin, AM, Lichtner, P, Lindgren, CM, Lindström, J, Linneberg, A, Loos, RJF, Lorbeer, R, Lorentzon, M, Luan, J, Luben, R, Lyssenko, V, Mahajan, A, Mangino, M, Manunta, P, Marie Justesen, J, McArdle, WL, McCarthy, MI, Mcknight, B, Medina-Gomez, C, Metspalu, A, Mihailov, E, Milani, L, Mills, R, Mohlke, KL, Monda, KL, Montasser, ME, Morris, AP, Musk, AW, Mägi, R, Männistö, S, Müller, G, Müller-Nurasyid, M, Narisu, N, Njølstad, I, Nolte, IM, North, KE, O'Connell, JR, Ohlsson, C, Oldehinkel, AJ, Ong, KK, Oostra, BA, Osmond, C, Palmer, LJ, Palotie, A, Pankow, JS, Paternoster, L, Pedersen, O, Penninx, BW, Perola, M, Peters, A, Pichler, I, Pilia, MG, Polašek, O, Pramstaller, PP, Prokopenko, I, Psaty, BM, Puolijoki, H, Pérusse, L, Qi, L, Raitakari, OT, Rankinen, T, Rao, DC, Rauramaa, R, Rayner, NW, Ribel-Madsen, R, Rice, TK, Richards, M, Ridker, PM, Ried, JS, Rivadeneira, F, Rose, LM, Rudan, I, Ryan, KA, Salomaa, V, Salvi, E, Sanna, S, Sarzynski, MA, Schlessinger, D, Scholtens, S, Schwarz, PEH, Scott, RA, Sebert, S, Shudiner, AR, Smit, JH, Smith, MT, Snieder, H, Southam, L, Sparsø, TH, Spector, TD, Stančáková, A, Stefansson, K, Steinthorsdottir, V, Stirrups, K, Stolk, RP, Strachan, DP, Strauch, K, Stringham, HM, Stumvoll, M, Swertz, MA, Swift, AJ, Sørensen, TIA, Tachmazidou, I, Tee Khaw, K, Teumer, A, Thorleifsson, G, Thorsteinsdottir, U, Tremblay, A, Tsafantakis, E, Tuomilehto, J, Tönjes, A, Uitterlinden, AG, Uusitupa, M, van der Harst, P, van der Most, PJ, van Dongen, J, van Duijn, CM, Van Vliet-Ostaptchouk, JV, Vandenput, L, Vartiainen, E, Venturini, C, Verweij, N, Viikari, JS, Vitart, V, Vohl, M-C, Vollenweider, P, Vonk, JM, Völker, U, Waeber, G, Walker, RW, Wang, SR, Wareham, NJ, Watkins, H, Widén, E, Wild, SH, Willems, SM, Willemsen, G, Wilsgaard, T, Wilson, JF, Winkler, TW, Wong, A, Wright, AF, Yerges-Armstrong, LM, Zeggini, E, Zhang, W   +275 more
core   +29 more sources

Antibody‐Empowered Nanomedicine for Precise Biomedical Applications

Advanced Science, EarlyView.
This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen, Xinglin Chen, Zhenhao Gao, Meng Sun, Yaozong Yu, Fang Lv, Qiujun Wang, Jinfeng Zhang   +7 more
wiley   +1 more source

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, EarlyView.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

CD47 is required for mesenchymal progenitor proliferation and fracture repair

Bone Research
CD47 is a ubiquitous and pleiotropic cell-surface receptor. Disrupting CD47 enhances injury repair in various tissues but the role of CD47 has not been studied in bone injuries.
Robert L. Zondervan, Christina A. Capobianco, Daniel C. Jenkins, John D. Reicha, Livia Fredrick, Charles Lam, Jeanna T. Schmanski, Jeffery S. Isenberg, Jaimo Ahn, Ralph S. Marcucio, Kurt D. Hankenson   +10 more
doaj   +1 more source

Human CD47 Expression Permits Survival of Porcine Cells in Immunodeficient Mice that Express SIRPα Capable of Binding to Human CD47

Cell Transplantation, 2011
Signal regulatory protein α (SIRPα) is a critical immune inhibitory receptor on macrophages, and its interaction with CD47 prevents autologous phagocytosis.
Chunfeng Wang, Hui Wang, Kentaro Ide, Yuantao Wang, Nico Van Rooijen, Hideki Ohdan, Yong-Guang Yang M.D., Ph.D.   +6 more
doaj   +1 more source

Gen-Expressionsanalyse aus autoptischen Formalin-fixierten und Paraffin- eingebetteten Gewebeproben von Multiple Sklerose Patienten [PDF]

, 2013
A protocol for RNA isolation from FFPE brain tissue was introduced and optimized in the laboratory. It was demonstrated that both, RNA yield and the ratio of light absorption at 260 nm vs.
Eisele, Sylvia
core  

Harnessing nanomaterials to precisely regulate the immunosuppressive tumor microenvironment for enhanced immunotherapy

BMEMat, EarlyView.
The immunosuppressive tumor microenvironment, characterized by hypoxia, redox imbalance, elevated interstitial fluid pressure, and acidity, was comprehensively elucidated. This review discussed the etiology and consequences of the characteristics of the immunosuppressive tumor microenvironment, and analyzed the recent advancements in nanomaterials for ...
Wen Zhang, Xueyin Hu, Wei Cheng, Lumeng Zhang, Yuanfang Chen, Qinrui Fu, Luntao Liu, Saijun Fan   +7 more
wiley   +1 more source

CD47 knockout mice exhibit improved recovery from spinal cord injury

Neurobiology of Disease, 2011
Recent data have implicated thrombospondin-1 (TSP-1) signaling in the acute neuropathological events that occur in microvascular endothelial cells (ECs) following spinal cord injury (SCI) (Benton et al., 2008b).
Scott A. Myers, William H. DeVries, Kariena R. Andres, Mark J. Gruenthal, Richard L. Benton, James B. Hoying, Theo Hagg, Scott R. Whittemore   +7 more
doaj   +1 more source

Changes in renal medulla gene expression in a pre-clinical model of post cardiopulmonary bypass acute kidney injury [PDF]

, 2014
BACKGROUND: Acute kidney injury (AKI) is a common and serious complication of cardiac surgery using cardiopulmonary bypass (CPB). The pathogenesis is poorly understood and the study of AKI in rodent models has not led to improvements in clinical outcomes.
Angelini, Gianni D, Caputo, Massimo, Ghorbel, Mohamed, Murphy, Gavin, Patel, Nishith, Sheikh, Maimuna   +5 more
core   +3 more sources

Differential regulation by CD47 and thrombospondin-1 of extramedullary erythropoiesis in mouse spleen [PDF]

, 2023
Rajdeep Banerjee, Thomas J. Meyer, Maggie Cam, Sukhbir Kaur, David D. Roberts   +4 more
openalex   +1 more source