Results 101 to 110 of about 36,599 (239)

Tumor-associated macrophages and macrophage-related immune checkpoint expression in sarcomas

OncoImmunology, 2020
Early trials for immune checkpoint inhibitors in sarcomas have delivered mixed results, and efforts to improve outcomes now look to combinatorial strategies with novel immunotherapeutics, including some that target macrophages.
Amanda R. Dancsok, Dongxia Gao, Anna F. Lee, Sonja Eriksson Steigen, Jean-Yves Blay, David M. Thomas, Robert G. Maki, Torsten O. Nielsen, Elizabeth G. Demicco   +8 more
doaj   +1 more source

Harnessing nanomaterials to precisely regulate the immunosuppressive tumor microenvironment for enhanced immunotherapy

BMEMat, EarlyView.
The immunosuppressive tumor microenvironment, characterized by hypoxia, redox imbalance, elevated interstitial fluid pressure, and acidity, was comprehensively elucidated. This review discussed the etiology and consequences of the characteristics of the immunosuppressive tumor microenvironment, and analyzed the recent advancements in nanomaterials for ...
Wen Zhang, Xueyin Hu, Wei Cheng, Lumeng Zhang, Yuanfang Chen, Qinrui Fu, Luntao Liu, Saijun Fan   +7 more
wiley   +1 more source

CD47 is required for mesenchymal progenitor proliferation and fracture repair

Bone Research
CD47 is a ubiquitous and pleiotropic cell-surface receptor. Disrupting CD47 enhances injury repair in various tissues but the role of CD47 has not been studied in bone injuries.
Robert L. Zondervan, Christina A. Capobianco, Daniel C. Jenkins, John D. Reicha, Livia Fredrick, Charles Lam, Jeanna T. Schmanski, Jeffery S. Isenberg, Jaimo Ahn, Ralph S. Marcucio, Kurt D. Hankenson   +10 more
doaj   +1 more source

Supplementary figures 1-4 from Inhibition of CD47 Effectively Targets Pancreatic Cancer Stem Cells via Dual Mechanisms

, 2023
Michele Cioffi, Sara Maria David Trabulo, Manuel Hidalgo, Eithne Costello, William Greenhalf, Mert Erkan, Jörg Kleeff, Bruno Sáinz, Christopher Heeschen   +8 more
openalex   +1 more source

Harnessing chimeric antigen receptor macrophages against solid tumors

Cancer Communications, EarlyView.
Abstract Macrophages are prevalent in multiple tumors and exhibit diverse and potent functional activities. Therapeutic reprogramming of macrophage phenotypes represents a promising strategy for cancer immunotherapy. Engineering chimeric antigen receptors (CARs) to endow macrophages with anti‐tumor capacities demonstrated encouraging efficacy ...
Mengru Wang, Zhen Qin, Xiu‐Wu Bian, Yu Shi   +3 more
wiley   +1 more source

589 Enhancement of the anti-tumor effects of CD47 blockade in solid tumors by combination with targeted radioimmunotherapy [PDF]

, 2021
Sagarika Pachhal, Emily Greer, Jesse Hwang, Qing Liang, Mary Chen, Eileen M. Geoghegan, Helen Kotanides, Dale L. Ludwig, Denis Beckford   +8 more
openalex   +1 more source

Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis [PDF]

, 2016
In sarcoidosis, the proinflammatory cytokines interferon gamma, tumour necrosis factor and interleukin-6 are released by monocyte-derived macrophages and lymphocytes in the lungs and other affected tissues. Regulatory receptors expressed on monocytes and
A Crawshaw, AD Vorselaars, AS Bansal, C Prior, CI Daïen, D De Groote, D Hijdra, D Lecossier, DG Walker, DR Moller, GJ Friou, GJ Gibson, GJ Wright, H Fehrenbach, HM Cherwinski, J Baran, J Carlisle, J Unitt, JC Grutters, JP Utz, K Lindahl-Kiessling, K Sahashi, KW Moore, L Landsman, L Ziegler-Heitbrock, M Steffen, MC Jenmalm, MP Chao, O Selroos, P Rottoli, R Gorczynski, RJ Snelgrove, RM Gorczynski, RP Baughman, RP Baughman, S Gao, S Gilbert, SA Eming, SL Kunkel, T Hussell, Y Li   +40 more
core   +2 more sources

Mechanism and role of regulated cell death in tumor immunity and immunotherapy

Cancer Communications, EarlyView.
Abstract Cancer immune checkpoint inhibitors (ICIs) have brought breakthroughs, but only about one‐third of cancer patients benefit from ICIs. In recent years, targeting non‐apoptotic regulated cell death (RCD) subtypes, such as ferroptosis, necroptosis, autophagy, cuproptosis, and pyroptosis, has emerged as a novel strategy in cancer therapy due to ...
Jingwen Hu, Yan Li, Bingjie Lian, Yitao Mao, Luqing Zhao   +4 more
wiley   +1 more source

Characterization of the Pathophysiological Role of CD47 in Uveal Melanoma

Molecules, 2019
Uveal melanoma (UM) represents the most frequent primary intraocular tumor, however, limited therapeutic options are still available. We have previously shown that cluster of differentiation 47 (CD47) is significantly upregulated in UM cells following ...
Maria Cristina Petralia, Emanuela Mazzon, Paolo Fagone, Andrea Russo, Antonio Longo, Teresio Avitabile, Ferdinando Nicoletti, Michele Reibaldi, Maria Sofia Basile   +8 more
doaj   +1 more source

CD47 (Cluster of differentiation 47): an anti-phagocytic receptor with a multitude of signaling functions

Animal Cells and Systems, 2020
CD47 is a tumor-associated antigen best known for its ability to bind counter-receptors on the surface of professional phagocytes as an immune-evasion strategy.
Pascal Leclair, Chinten James Lim
doaj   +1 more source