Results 111 to 120 of about 36,599 (239)

Figure S1 from CD47 Blockade as an Adjuvant Immunotherapy for Resectable Pancreatic Cancer

, 2023
Alex D. Michaels, Timothy E. Newhook, Sara J. Adair, Sho Morioka, Bernadette J. Goudreau, Sarbajeet Nagdas, Matthew G. Mullen, Jesse Persily, Timothy N. J. Bullock, Craig L. Slingluff, Kodi S. Ravichandran, J. Thomas Parsons, Todd W. Bauer   +12 more
openalex   +1 more source

Gen-Expressionsanalyse aus autoptischen Formalin-fixierten und Paraffin- eingebetteten Gewebeproben von Multiple Sklerose Patienten [PDF]

, 2013
A protocol for RNA isolation from FFPE brain tissue was introduced and optimized in the laboratory. It was demonstrated that both, RNA yield and the ratio of light absorption at 260 nm vs.
Eisele, Sylvia
core  

CD24 is a promising immunotherapeutic target for enhancing efficacy of third‐generation EGFR‐TKIs on EGFR‐mutated lung cancer

Cancer Communications, EarlyView.
Abstract Background Third‐generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) show initial efficacy in EGFR‐mutated lung cancer, but residual disease persists. This study aimed to investigate cluster of differentiation 24 (CD24) as a translational immunotherapeutic target for enhancing third‐generation EGFR‐TKI efficacy.
Jiaqi Liang, Guoshu Bi, Xiaolong Huang, Zhijie Xu, Yiwei Huang, Yunyi Bian, Guangyao Shan, Wei Guo, Yuanliang Yan, Qihai Sui, Xiaodong Yang, Zhencong Chen, Tao Lu, Huan Zhang, Qun Wang, Wei Jiang, Cheng Zhan   +16 more
wiley   +1 more source

Nanogel‐Mediated Immunotherapy to Tackle Cancer and Inflammatory Diseases

ChemistryEurope, EarlyView.
Nanogels formed through self‐assembly, microemulsion, or precipitation polymerization method enable precise delivery of immunotherapeutic factors and immune cell targeting, thus effectively modulating immune responses. This review highlights recent advances in stimuli‐responsive nanogel design, underlying mechanisms, and their potentials to tackle ...
Ziwen Zhang, Jinxia Wang, Guang‐Zhi Jin, István Bányai, Dzmitry Shcharbin, Ivan Stoikov, Mingwu Shen, Xiangyang Shi   +7 more
wiley   +1 more source

Extracellular Vesicle‐Based mRNA Therapeutics and Vaccines

Exploration, EarlyView.
This review provides a comprehensive analysis of recent advancements in extracellular vesicle (EV)‐based messenger RNA (mRNA) applications for therapeutics and vaccines. It systematically outlines strategies for mRNA encapsulation within EVs and elucidates the challenges associated with this technology, offering insights into future research directions
Qi Li, Haonan Xing, Abid Naeem, Kaiyue Zhang, Aiping Zheng, Yuanyu Huang, Mei Lu   +6 more
wiley   +1 more source

Targeting CD47 and Angiogenesis Demonstrates Effective Anti-Tumor Effect in Bladder Cancer

Biomedicines
Background: Although immunotherapy has shown potential in cancer treatment, current immunotherapeutics for bladder cancer are limited by a low response rate.
Xiting Huang, Qian Wang, Yanyang Nan, Xuyao Zhang, Ke Xu, Dianwen Ju, Weihong Ding   +6 more
doaj   +1 more source

Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma

International Journal of Cancer, EarlyView.
Abstract Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first‐line tyrosine kinase inhibitor therapies, such as sorafenib and lenvatinib, remains a significant clinical challenge.
Longtao Zhao, Junjie Cheng, Yiming Zheng, Jing Wu, Jia Fan, Haixiang Sun, Chao Gao   +6 more
wiley   +1 more source

Ubiquitination of ASCL1 mediates CD47 transcriptional activation of the AKT signaling pathway, and glycolysis promotes osteogenic differentiation of hBMSCs [PDF]

, 2023
Jimei Zhang, Ling Zhu, Jianping Zhou, Qunying Yu, Guangyuan Yang, Ke Zhao, Chaoli Luo, Jianguo Meng, Jing Liu, Xuming Yang   +9 more
openalex   +1 more source

New trend in molecular diagnostics: Insights from the tumor microenvironment

Interdisciplinary Medicine, EarlyView.
The graphical abstract outline the key elements in TME‐based molecular diagnostics, including biomarker exploration, diagnostic methods, and diagnostic models. Source: Created with BioRender.com. Abstract Molecular diagnosis has revolutionized cancer precision medicine.
Baiyuan Fan, Jiahui Zhang, Chong Li, Xu Zhang   +3 more
wiley   +1 more source

Tumor cell‐derived vaccines: Advances, challenges, and future prospects

Interdisciplinary Medicine, EarlyView.
Classification and Optimization Directions for Tumor Cell‐Derived Vaccines. This diagram systematically illustrates the four major categories of tumor cell‐derived vaccines, along with their core optimization strategies. The upper section presents the four primary vaccine types: autologous/allogeneic whole‐cell vaccines (which preserve the complete ...
Jiaye Lu, Yu Meng, Xinwei Shi, Yingchao Zhao, David M. Irwin, Xinyue Zhang, Yiqiao Zhang, Quangang Zhu, Zongguang Tai, Zhongjian Chen   +9 more
wiley   +1 more source