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A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape [PDF]
, 2016 This is the final version of the article. Available from the publisher via the DOI in this record.Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time.Abecasis, GR, Ahluwalia, TS, Albrecht, E, Bakker, SJL, Barlassina, C, Bartz, TM, Beilby, J, Bellis, C, Bergman, RN, Bergmann, S, Blangero, J, Blüher, M, Boehnke, M, Boerwinkle, E, Bonnycastle, LL, Boomsma, DI, Borecki, IB, Bornstein, SR, Bouchard, C, Bragg-Gresham, JL, Bruinenberg, M, Cadby, G, Campbell, H, Carola Zillikens, M, Chambers, JC, Chasman, DI, Chen, Y-DI, Chiang, CWK, Chines, PS, Chu, AY, Collins, FS, Couto Alves, A, Cucca, F, Cupples, LA, Cusi, D, D'Avila, F, de Geus, EJC, Dedoussis, G, Deloukas, P, Dimitriou, M, Döring, A, Eklund, N, Eriksson, J, Eriksson, JG, Esko, T, Farmaki, A-E, Farrall, M, Feitosa, MF, Ferreira, T, Fischer, K, Forouhi, NG, Fox, C, Frayling, T, Friedrich, N, Gansevoort, RT, Gieger, C, Gjesing, AP, Glorioso, N, Goel, A, Gorski, M, Graff, M, Grallert, H, Grarup, N, Grewal, J, Groop, LC, Gräßler, J, Hamsten, A, Hansen, T, Harder, MN, Hartman, CA, Hassinen, M, Hastie, N, Hattersley, AT, Havulinna, AS, Hayward, C, Heard-Costa, NL, Heid, IM, Heliövaara, M, Hicks, AA, Hillege, H, Hirschhorn, JN, Hofman, A, Holmen, O, Homuth, G, Hottenga, J-J, Hu, F, Hua Zhao, J, Huffman, JE, Hui, J, Hunter, DJ, Husemoen, LL, Hveem, K, Hysi, PG, Isaacs, A, Ittermann, T, Jackson, AU, Jalilzadeh, S, James, AL, Jarvelin, M-R, Jeff M, J, Jokinen, E, Jousilahti, P, Ju Sung, Y, Jula, A, Justice, AE, Jørgensen, T, Kajantie, E, Kanoni, S, Kaplan, RC, Karaleftheri, M, Keinanen-Kiukaanniemi, SM, Kinnunen, L, Knekt, PB, Koistinen, HA, Kolcic, I, Kooner, IK, Kooner, JS, Koskinen, S, Kovacs, P, Kristiansson, K, Kuh, D, Kutalik, Z, Kuusisto, J, Kyriakou, T, Kähönen, M, Laakso, M, Lahti, J, Laitinen, T, Lakka, TA, Langenberg, C, Leach, IM, Lehtimäki, T, Lewin, AM, Lichtner, P, Lindgren, CM, Lindström, J, Linneberg, A, Loos, RJF, Lorbeer, R, Lorentzon, M, Luan, J, Luben, R, Lyssenko, V, Mahajan, A, Mangino, M, Manunta, P, Marie Justesen, J, McArdle, WL, McCarthy, MI, Mcknight, B, Medina-Gomez, C, Metspalu, A, Mihailov, E, Milani, L, Mills, R, Mohlke, KL, Monda, KL, Montasser, ME, Morris, AP, Musk, AW, Mägi, R, Männistö, S, Müller, G, Müller-Nurasyid, M, Narisu, N, Njølstad, I, Nolte, IM, North, KE, O'Connell, JR, Ohlsson, C, Oldehinkel, AJ, Ong, KK, Oostra, BA, Osmond, C, Palmer, LJ, Palotie, A, Pankow, JS, Paternoster, L, Pedersen, O, Penninx, BW, Perola, M, Peters, A, Pichler, I, Pilia, MG, Polašek, O, Pramstaller, PP, Prokopenko, I, Psaty, BM, Puolijoki, H, Pérusse, L, Qi, L, Raitakari, OT, Rankinen, T, Rao, DC, Rauramaa, R, Rayner, NW, Ribel-Madsen, R, Rice, TK, Richards, M, Ridker, PM, Ried, JS, Rivadeneira, F, Rose, LM, Rudan, I, Ryan, KA, Salomaa, V, Salvi, E, Sanna, S, Sarzynski, MA, Schlessinger, D, Scholtens, S, Schwarz, PEH, Scott, RA, Sebert, S, Shudiner, AR, Smit, JH, Smith, MT, Snieder, H, Southam, L, Sparsø, TH, Spector, TD, Stančáková, A, Stefansson, K, Steinthorsdottir, V, Stirrups, K, Stolk, RP, Strachan, DP, Strauch, K, Stringham, HM, Stumvoll, M, Swertz, MA, Swift, AJ, Sørensen, TIA, Tachmazidou, I, Tee Khaw, K, Teumer, A, Thorleifsson, G, Thorsteinsdottir, U, Tremblay, A, Tsafantakis, E, Tuomilehto, J, Tönjes, A, Uitterlinden, AG, Uusitupa, M, van der Harst, P, van der Most, PJ, van Dongen, J, van Duijn, CM, Van Vliet-Ostaptchouk, JV, Vandenput, L, Vartiainen, E, Venturini, C, Verweij, N, Viikari, JS, Vitart, V, Vohl, M-C, Vollenweider, P, Vonk, JM, Völker, U, Waeber, G, Walker, RW, Wang, SR, Wareham, NJ, Watkins, H, Widén, E, Wild, SH, Willems, SM, Willemsen, G, Wilsgaard, T, Wilson, JF, Winkler, TW, Wong, A, Wright, AF, Yerges-Armstrong, LM, Zeggini, E, Zhang, W +275 morecore +29 more sourcesReal‐Time In Vivo Visualization of Tumor‐Associated Macrophage Reprogramming Using a Nitric Oxide‐Activatable NIR‐II Nanoinducer
Advanced Science, EarlyView.Reprogramming tumor‐associated macrophages is a promising therapeutic strategy for solid tumors. Here, a nitric oxide (NO)‐activatable NIR‐II fluorescence/photoacoustic nanoinducer (I/E@M2pep) that simultaneously facilitates and visualizes the repolarization of TAMs to an M1‐like phenotype is reported, thereby enhancing anti‐tumor efficacy through M1 ...Qian Chen, Meng Li, Tuanwei Li, Chen Yang, Xiaohu Yang, Hongchao Yang, Yejun Zhang, Chunyan Li, Qiangbin Wang +8 morewiley +1 more sourceCharacterization of the Pathophysiological Role of CD47 in Uveal Melanoma
Molecules, 2019 Uveal melanoma (UM) represents the most frequent primary intraocular tumor, however, limited therapeutic options are still available. We have previously shown that cluster of differentiation 47 (CD47) is significantly upregulated in UM cells following ...Maria Cristina Petralia, Emanuela Mazzon, Paolo Fagone, Andrea Russo, Antonio Longo, Teresio Avitabile, Ferdinando Nicoletti, Michele Reibaldi, Maria Sofia Basile +8 moredoaj +1 more sourceTargeting CD47 in Sézary syndrome with SIRPαFc
Blood Advances, 2019 AbstractSézary syndrome (SS), the leukemic variant of cutaneous T-cell lymphoma, has limited treatment options and rare occurrences of long-term remission, thus warranting research into new treatment approaches. CD47 has emerged as a promising target for multiple tumor types, but its role in SS remains unknown.Lisa D. S. Johnson, Swati Banerjee, Oleg Kruglov, Natasja Nielsen Viller, Steven M. Horwitz, Alexander Lesokhin, Jasmine Zain, Christiane Querfeld, Robert Chen, Craig Okada, Ahmed Sawas, Owen A. O’Connor, Eric L. Sievers, Yaping Shou, Robert A. Uger, Mark Wong, Oleg E. Akilov +16 moreopenaire +2 more sourcesPyroptosis‐Inducing Engineered Microparticles for Cancer Immunotherapy
Advanced Science, EarlyView.Engineered microparticles co‐delivering geldanamycin and dual nanobodies induce targeted pyroptosis and block PD‐L1 and CD47 pathways, reprogramming the tumor microenvironment and achieving potent antitumor immunity in lung cancer models with minimal toxicity.Tianli Hao, Zihan Deng, Yufei Liu, Li Liu, Deqiang Deng, Muyang Yang, Yuanyuan Geng, Yao Sun, Beilei Yue, Jonathan F. Lovell, Yushuai Liu, Lisen Lu, Honglin Jin +12 morewiley +1 more sourceHarnessing nanomaterials to precisely regulate the immunosuppressive tumor microenvironment for enhanced immunotherapy
BMEMat, EarlyView.The immunosuppressive tumor microenvironment, characterized by hypoxia, redox imbalance, elevated interstitial fluid pressure, and acidity, was comprehensively elucidated. This review discussed the etiology and consequences of the characteristics of the immunosuppressive tumor microenvironment, and analyzed the recent advancements in nanomaterials for ...Wen Zhang, Xueyin Hu, Wei Cheng, Lumeng Zhang, Yuanfang Chen, Qinrui Fu, Luntao Liu, Saijun Fan +7 morewiley +1 more sourceCold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment
BMEMat, EarlyView.Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen +8 morewiley +1 more source
