Results 121 to 130 of about 38,316 (246)

Surface modification of immune cells with thiolated polymers that mediate cellular recognition [論文要旨及び審査の要旨] [PDF]

, 2019
関西大
Sugimoto Shunsuke, 杉本 駿介
core   +1 more source

Protein tyrosine phosphatases as emerging targets for cancer immunotherapy

British Journal of Pharmacology, EarlyView.
Abstract Contemporary strategies in cancer immunotherapy, despite remarkable success, remain constrained by inherent limitations such as suboptimal patient responses, the emergence of drug resistance, and the manifestation of pronounced adverse effects. Consequently, the need for alternative strategies for immunotherapy becomes clear.
Zihan Qu, Jiajun Dong, Zhong‐Yin Zhang
wiley   +1 more source

CD47-blocking antibody confers metabolic benefits against obesity

Cell Reports Medicine
Summary: CD47-blocking antibody is a well-known potential antibody drug for tumor immunotherapy. However, it is unclear whether CD47-blocking antibody can protect against metabolic disorders.
Yajuan Su, Jingyu Sun, Xiaobo Li, Feier Huang, Yunhui Kong, Zian Chen, Jingzhi Zhang, Duran Qin, Xiangyi Chen, Zhaoyue Wang, Yu Pei, Mengting Gong, Kaijiang Yang, Minglu Xu, Yu Dong, Qing He, Zhen-Ning Zhang, Zhejin Sheng, Qiaolin Deng, Hong Wang, Gaowei Wang, Ping Hu, Rongrong Le, Shaorong Gao, Weida Li   +24 more
doaj   +1 more source

Targeting Wnt3a and Loxl2 Synergistically Induces Ferroptosis in Liver Cancer Stem Cells and Suppresses Tumorigenesis

Cancer Science, EarlyView.
Using bioinformatic analysis, LCSC models, and transgenic mice, we demonstrate that co‐inhibition of Wnt3a and Loxl2 potently triggers ferroptosis and inhibits orthotopic liver tumorigenesis. The enhanced antitumor effect upon dual targeting, mediated through ZEB1 upregulation, highlights a promising combinatory approach against HCC.
Guanghui Ren, Qingwei Cong, Jing Wang, Wenyue Gao, Yunpeng Guan, Lianxin Zhu, Ying Zhu   +6 more
wiley   +1 more source

Immunotherapeutic Blockade of CD47 Increases Virus Neutralization Antibodies

Vaccines
Background/Objectives: CD47 is a cell surface glycoprotein moderately expressed in healthy cells and upregulated in cancer and viral infected cells.
Lamin B. Cham, Thamer A. Hamdan, Hilal Bhat, Bello Sirajo, Murtaza Ali, Khaled Saeed Tabbara, Eman Farid, Mohamed-Ridha Barbouche, Tom Adomati   +8 more
doaj   +1 more source

Non‐Coding RNAs in Breast Cancer Radioresistance: Mechanisms, Functional Roles and Translational Potentials

Cell Proliferation, EarlyView.
Non‐coding RNAs (ncRNAs) regulate breast cancer radioresistance via cell cycle, DNA repair and tumour microenvironment pathways. Targeting ncRNAs (e.g., HOTAIR and miR‐155) with RNA‐based therapies (ASOs and CRISPR) shows promise but faces delivery challenges.
Xiaohui Zhao, Yuting Qiu, Jie Chen, Danni Wang, Zairui Wang, Shuang Ma, Yimin Liu, Guoying Liu, Zhuofei Bi   +8 more
wiley   +1 more source

Washington University Record, July 13, 2000 [PDF]

, 2000
https://digitalcommons.wustl.edu/record/1867/thumbnail ...

core   +1 more source

A UK key opinion leader perspective: Navigating the immunological and logistical transformation brought by stem cell‐derived islets for the treatment of type 1 diabetes

Diabetic Medicine, EarlyView.
Abstract Aims To explore UK key‐opinion leader perspectives on the future role of stem cell‐derived islets (sc‐islets) in islet transplantation for people with type 1 diabetes (T1D). Methods Four UK‐based key‐opinion leaders evaluated current limitations of donor islet transplantation and reviewed emerging evidence, clinical pathways and logistical ...
Thomas Strakosch, Shareen Forbes
wiley   +1 more source

Targeting CD47 and Angiogenesis Demonstrates Effective Anti-Tumor Effect in Bladder Cancer

Biomedicines
Background: Although immunotherapy has shown potential in cancer treatment, current immunotherapeutics for bladder cancer are limited by a low response rate.
Xiting Huang, Qian Wang, Yanyang Nan, Xuyao Zhang, Ke Xu, Dianwen Ju, Weihong Ding   +6 more
doaj   +1 more source

Secular Changes in Eta Carinae's Wind 1998-2011

, 2012
Stellar wind-emission features in the spectrum of eta Carinae have decreased by factors of 1.5-3 relative to the continuum within the last 10 years. We investigate a large data set from several instruments (STIS, GMOS, UVES) obtained between 1998 and ...
Andrea Mehner, Cassatella, Corcoran, Corcoran, Cox, Damineli, Davidson, Davidson, Davidson, Davidson, Davidson, Davidson, Davidson, Davidson, Davidson, Davidson, Dorland, Draine, Frederick M. Walter, Fullerton, Groh, Groh, Gull, Hillier, Hillier, Hillier, Humphreys, Humphreys, Ishibashi, Ishibashi, John C. Martin, Kashi, Kazunori Ishibashi, Kris Davidson, Madura, Maeder, Martin, Martin, Martin, Martin, María Teresa Ruiz, Mehner, Mehner, Mehner, Mehner, Najarro, Nielsen, Osterbrock, Owocki, Richardson, Roberta M. Humphreys, Smith, Smith, Soker, Soker, Soker, Stevens, Teodoro, van Genderen, Weis, Whitelock, Zanella, Zethson   +62 more
core   +1 more source