Results 11 to 20 of about 36,599 (239)

CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions [PDF]

, 2013
CD47 plays an important but incompletely understood role in the innate and adaptive immune responses. CD47, also called integrin-associated protein, has been demonstrated to associate in cis with β1 and β3 integrins. Here we test the hypothesis that CD47
Verónica Azcutia, Matthew Routledge, Marcie R. Williams, Gail Newton, William A. Frazier, André Manica, Kevin Croce, Charles A. Parkos, Angela B. Schmider, Melissa V. Turman, Roy J. Soberman, Francis W. Luscinskas   +11 more
openalex   +4 more sources

CD47 as a Potential Target to Therapy for Infectious Diseases

Antibodies, 2020
The integrin associated protein (CD47) is a widely and moderately expressed glycoprotein in all healthy cells. Cancer cells are known to induce increased CD47 expression.
Lamin B. Cham, Tom Adomati, Fanghui Li, Murtaza Ali, Karl S. Lang   +4 more
doaj   +1 more source

CD47(low) status on CD4 effectors is necessary for the contraction/resolution of the immune response in humans and mice. [PDF]

PLoS ONE, 2012
How do effector CD4 T cells escape cell death during the contraction of the immune response (IR) remain largely unknown. CD47, through interactions with thrombospondin-1 (TSP-1) and SIRP-α, is implicated in cell death and phagocytosis of malignant cells.
Vu Quang Van, Nobuyasu Baba, Manuel Rubio, Keiko Wakahara, Benoit Panzini, Carole Richard, Genevieve Soucy, Denis Franchimont, Genevieve Fortin, Ana Carolina Martinez Torres, Lauriane Cabon, Santos Susin, Marika Sarfati   +12 more
doaj   +1 more source

CD47 Enhances Cell Viability and Migration Ability but Inhibits Apoptosis in Endometrial Carcinoma Cells via the PI3K/Akt/mTOR Signaling Pathway

Frontiers in Oncology, 2020
Purposes: To measure expression levels of CD47 during endometrial carcinoma development, and to determine specific modulatory effects.Methods: CD47 expression levels in endometrial carcinoma tissues and adjacent tissues were analyzed using qRT-PCR.
Yun Liu, Yue Chang, Xinhong He, Yixuan Cai, Hao Jiang, Ru Jia, Jiyan Leng   +6 more
doaj   +1 more source

Regulation of CD47 expression on CD14+ monocytes by interferon-α in PBC patients

Frontiers in Immunology, 2023
BackgroundPrimary biliary cholangitis (PBC) is a chronic intrahepatic cholestatic autoimmune liver disease characterized by inflammatory injury of small and medium-sized bile ducts in the liver.
Xi Su, Xi Su, Wenwen Jin, Wenwen Jin, Lizhi Liu, Zifei Zhu, Zifei Zhu, Cunyan Li, Cunyan Li   +8 more
doaj   +1 more source

Extracellular Matrix Protein Tenascin C Increases Phagocytosis Mediated by CD47 Loss of Function in Glioblastoma. [PDF]

, 2019
Glioblastomas (GBM) are highly infiltrated by myeloid-derived innate immune cells that contribute to the immunosuppressive nature of the brain tumor microenvironment (TME).
Gao, Peisong, Lal, Bachchu, Laterra, John, Lee, Richard S, Li, Jian Jian, Liu, Senquan, Lopez-Bertoni, Hernando, Ma, Ding, Wang, Shuyan, Wei, Shuang, Wilson, Mary Ann, Xia, Shuli, Ying, Mingyao, Zhan, Daqian, Zhang, Hao   +14 more
core   +2 more sources

Evaluation of CD47 in the Suppressive Tumor Microenvironment and Immunotherapy in Prostate Cancer

Journal of Immunology Research, 2023
Background. CD47 has high levels of expression in malignant cancer cells, which binds to SIRP-α to release the “don’t eat me” signal and prevents mononuclear macrophages from phagocytosing the cells.
Qianqian Wang, Chunxaing Feng, Yuchun Chen, Tianming Peng, Yong Li, Kunlin Wu, Xiaoyong Pu, Hanzhong Chen, Jiumin Liu   +8 more
doaj   +1 more source

CD47 Expression in Non-Melanoma Skin Cancers and Its Clinicopathological Implications

Diagnostics, 2022
CD47 is a cell surface molecule and regulates diverse cellular responses. CD47 is highly expressed in cancer cells and has potential as a therapeutic target and prognostic factor in cancer patients. The expression patterns of CD47 in basal cell carcinoma
Seongsik Bang, Seungyun Jee, Hwangkyu Son, Hyebin Cha, Hosub Park, Jaekyung Myung, Joo Yeon Ko, Hyunsung Kim, Seungsam Paik   +8 more
doaj   +1 more source

Association between CD47 expression, clinical characteristics and prognosis in patients with advanced non‐small cell lung cancer

Cancer Medicine, 2020
Objective CD47 is an antiphagocytic molecule that contributes to tumor cell resistance in host immune surveillance. CD47 overexpression correlated with tumor progression and shorter survival in lung cancer.
Oscar Arrieta, Alejandro Aviles‐Salas, Mario Orozco‐Morales, Norma Hernández‐Pedro, Andrés F. Cardona, Luis Cabrera‐Miranda, Pedro Barrios‐Bernal, Giovanny Soca‐Chafre, Graciela Cruz‐Rico, María de Lourdes Peña‐Torres, Guadalupe Moncada‐Claudio, Laura‐Alejandra Ramirez‐Tirado   +11 more
doaj   +1 more source

An overview about erythrocyte membrane [PDF]

, 2010
© 2010 – IOS Press and the authors. All rights reservedIn the sixties and seventies, erythrocytes or red blood cells (RBCs) were extensively studied. Much has been learnt particularly concerning their metabolism and gas transporter function. In the past
Oliveira, Sofia de, Saldanha, Carlota
core   +1 more source