Results 11 to 20 of about 38,316 (246)

Evaluation of CD47 in the Suppressive Tumor Microenvironment and Immunotherapy in Prostate Cancer

Journal of Immunology Research, 2023
Background. CD47 has high levels of expression in malignant cancer cells, which binds to SIRP-α to release the “don’t eat me” signal and prevents mononuclear macrophages from phagocytosing the cells.
Qianqian Wang, Chunxaing Feng, Yuchun Chen, Tianming Peng, Yong Li, Kunlin Wu, Xiaoyong Pu, Hanzhong Chen, Jiumin Liu   +8 more
doaj   +1 more source

CD47 Expression in Non-Melanoma Skin Cancers and Its Clinicopathological Implications

Diagnostics, 2022
CD47 is a cell surface molecule and regulates diverse cellular responses. CD47 is highly expressed in cancer cells and has potential as a therapeutic target and prognostic factor in cancer patients. The expression patterns of CD47 in basal cell carcinoma
Seongsik Bang, Seungyun Jee, Hwangkyu Son, Hyebin Cha, Hosub Park, Jaekyung Myung, Joo Yeon Ko, Hyunsung Kim, Seungsam Paik   +8 more
doaj   +1 more source

Extracellular Matrix Protein Tenascin C Increases Phagocytosis Mediated by CD47 Loss of Function in Glioblastoma. [PDF]

, 2019
Glioblastomas (GBM) are highly infiltrated by myeloid-derived innate immune cells that contribute to the immunosuppressive nature of the brain tumor microenvironment (TME).
Gao, Peisong, Lal, Bachchu, Laterra, John, Lee, Richard S, Li, Jian Jian, Liu, Senquan, Lopez-Bertoni, Hernando, Ma, Ding, Wang, Shuyan, Wei, Shuang, Wilson, Mary Ann, Xia, Shuli, Ying, Mingyao, Zhan, Daqian, Zhang, Hao   +14 more
core   +2 more sources

Association between CD47 expression, clinical characteristics and prognosis in patients with advanced non‐small cell lung cancer

Cancer Medicine, 2020
Objective CD47 is an antiphagocytic molecule that contributes to tumor cell resistance in host immune surveillance. CD47 overexpression correlated with tumor progression and shorter survival in lung cancer.
Oscar Arrieta, Alejandro Aviles‐Salas, Mario Orozco‐Morales, Norma Hernández‐Pedro, Andrés F. Cardona, Luis Cabrera‐Miranda, Pedro Barrios‐Bernal, Giovanny Soca‐Chafre, Graciela Cruz‐Rico, María de Lourdes Peña‐Torres, Guadalupe Moncada‐Claudio, Laura‐Alejandra Ramirez‐Tirado   +11 more
doaj   +1 more source

Regulation of CD47 expression on CD14+ monocytes by interferon-α in PBC patients

Frontiers in Immunology, 2023
BackgroundPrimary biliary cholangitis (PBC) is a chronic intrahepatic cholestatic autoimmune liver disease characterized by inflammatory injury of small and medium-sized bile ducts in the liver.
Xi Su, Xi Su, Wenwen Jin, Wenwen Jin, Lizhi Liu, Zifei Zhu, Zifei Zhu, Cunyan Li, Cunyan Li   +8 more
doaj   +1 more source

An overview about erythrocyte membrane [PDF]

, 2010
© 2010 – IOS Press and the authors. All rights reservedIn the sixties and seventies, erythrocytes or red blood cells (RBCs) were extensively studied. Much has been learnt particularly concerning their metabolism and gas transporter function. In the past
Oliveira, Sofia de, Saldanha, Carlota
core   +1 more source

Metabolic reprogramming of efferocytosis in the tumour microenvironment: From apoptotic-cell clearance to therapeutic targeting. [PDF]

Clin Transl Med
This review systematically deconstructs the pathological efferocytic—metabolic axis in tumours, framing it as a three‐stage, self‐reinforcing cycle: from metabolite‐driven macrophage recruitment, through hijacked surface recognition, to post‐phagocytic metabolic reprogramming that locks in immunosuppression.
Yang Q, Yan J, Yang Q.
europepmc   +2 more sources

The convergence of radiation and immunogenic cell death signaling pathways. [PDF]

, 2012
Ionizing radiation (IR) triggers programmed cell death in tumor cells through a variety of highly regulated processes. Radiation-induced tumor cell death has been studied extensively in vitro and is widely attributed to multiple distinct mechanisms ...
Barcellos-Hoff, Mary H, Demaria, Sandra, Formenti, Silvia C, Golden, Encouse B, Pellicciotta, Ilenia   +4 more
core   +2 more sources

Identification of Schlafen-11 as a Target of CD47 Signaling That Regulates Sensitivity to Ionizing Radiation and Topoisomerase Inhibitors

Frontiers in Oncology, 2019
Knockdown or gene disruption of the ubiquitously expressed cell surface receptor CD47 protects non-malignant cells from genotoxic stress caused by ionizing radiation or cytotoxic chemotherapy but sensitizes tumors in an immune competent host to genotoxic
Sukhbir Kaur, Anthony L. Schwartz, David G. Jordan, David R. Soto-Pantoja, Bethany Kuo, Abdel G. Elkahloun, Lesley Mathews Griner, Craig J. Thomas, Marc Ferrer, Anish Thomas, Sai-Wen Tang, Vinodh N. Rajapakse, Yves Pommier, David D. Roberts   +13 more
doaj   +1 more source

CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions [PDF]

, 2013
CD47 plays an important but incompletely understood role in the innate and adaptive immune responses. CD47, also called integrin-associated protein, has been demonstrated to associate in cis with β1 and β3 integrins. Here we test the hypothesis that CD47
Alcaide P, Andrew D, Andrè Manica, Angela B. Schmider, Azcutia V, Barclay AN, Brittain JE, Brown E, Brown EJ, Charles A. Parkos, Chen C, Constantin G, Cooper D, de Vries HE, Dransfield I, Fortin G, Francis W. Luscinskas, Gail Newton, Han MH, Hogg N, Isenberg JS, Kevin J. Croce, Kim M, Lefort CT, Ley K, Lim YC, Lindberg FP, Luque A, Mandal AK, Marcie R. Williams, Mark H. Ginsberg, Matthew Routledge, McDonald JF, Melissa V. Turman, Miller LJ, Parkos CA, Quinn MT, Roy J. Soberman, Salas A, Shamri R, Shimaoka M, Sircar M, Smith A, Snapp KR, Stefanidakis M, Su X, Ticchioni M, Veronica Azcutia, William A. Frazier, Yang J   +49 more
core   +2 more sources