Results 11 to 20 of about 35,706 (250)

Facilitating cholangiocarcinoma inhibition by targeting CD47

Experimental and Molecular Pathology
Immune evasion is one of the mechanisms by which cancer cells acquire immunity during cancer development and progression. One of these is the increased expression of cluster of differentiation 47 (CD47), a transmembrane glycoprotein that protects cells ...
Kulthida Vaeteewoottacharn, Sakda Waraasawapati, Phattarin Pothipan, Ryusho Kariya, Saowaluk Saisomboon, Supawadee Bunthot, Chawalit Pairojkul, Kanlayanee Sawanyawisuth, Kazuhiko Kuwahara, Sopit Wongkham, Seiji Okada   +10 more
doaj   +3 more sources

Cancer Therapy Targeting CD47/SIRPα [PDF]

Cancers, 2021
In the past decade, the field of cancer immunotherapy has rapidly advanced, establishing a crucial role for immune checkpoint blockers in the treatment of a variety of cancer types. In parallel with these remarkable clinical developments, further efforts have focused on ways of unleashing adaptive immune responses against cancer.
Nazli Dizman, Elizabeth I. Buchbinder
openaire   +2 more sources

Targeting CD47 for cancer immunotherapy [PDF]

Journal of Hematology & Oncology, 2021
AbstractMuch progress has been made in targeting CD47 for cancer immunotherapy in solid tumors (ST) and hematological malignancies. We summarized the CD47-related clinical research and analyzed the research trend both in the USA and in China. As of August 28, 2021, there are a total 23 related therapeutic agents with 46 clinical trials in the NCT ...
Zhongxing Jiang, Hao Sun, Jifeng Yu, Wenzhi Tian, Yongping Song   +4 more
openaire   +3 more sources

CD47 [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2008
CD47, originally named integrin-associated protein, is a receptor for thrombospondin-1. A number of important roles for CD47 have been defined in regulating the migration, proliferation, and survival of vascular cells, and in regulation of innate and adaptive immunity.
Jeff S, Isenberg, David D, Roberts, William A, Frazier   +2 more
openaire   +3 more sources

CD47 Deficiency Ameliorates Ocular Autoimmune Inflammation [PDF]

Frontiers in Immunology, 2021
Autoimmune uveitis is a sight-threatening ocular inflammatory condition in which the retina and uveal tissues become a target of autoreactive immune cells. The CD47 is a ubiquitously expressed transmembrane protein which plays multiple roles in fundamental cellular functions including phagocytosis, proliferation, and adhesion. Signal regulatory protein
Yoko Okunuki, Steven J. Tabor, May Y. Lee, Kip M. Connor   +3 more
openaire   +3 more sources

Evaluation of CD47 in the Suppressive Tumor Microenvironment and Immunotherapy in Prostate Cancer

Journal of Immunology Research, 2023
Background. CD47 has high levels of expression in malignant cancer cells, which binds to SIRP-α to release the “don’t eat me” signal and prevents mononuclear macrophages from phagocytosing the cells.
Qianqian Wang, Chunxaing Feng, Yuchun Chen, Tianming Peng, Yong Li, Kunlin Wu, Xiaoyong Pu, Hanzhong Chen, Jiumin Liu   +8 more
doaj   +1 more source

CD47 expression is critical for CAR T-cell survival in vivo

Journal for ImmunoTherapy of Cancer, 2023
Background CD47 is an attractive immunotherapeutic target because it is highly expressed on multiple solid tumors. However, CD47 is also expressed on T cells.
Stephen Gottschalk, Phuong Nguyen, Christopher DeRenzo, Giedre Krenciute, Alex N Beckett, Peter Chockley, Shondra M Pruett-Miller, Peter Vogel, Heather Sheppard   +8 more
doaj   +1 more source

CD47 Expression in Non-Melanoma Skin Cancers and Its Clinicopathological Implications

Diagnostics, 2022
CD47 is a cell surface molecule and regulates diverse cellular responses. CD47 is highly expressed in cancer cells and has potential as a therapeutic target and prognostic factor in cancer patients. The expression patterns of CD47 in basal cell carcinoma
Seongsik Bang, Seungyun Jee, Hwangkyu Son, Hyebin Cha, Hosub Park, Jaekyung Myung, Joo Yeon Ko, Hyunsung Kim, Seungsam Paik   +8 more
doaj   +1 more source

Extracellular Matrix Protein Tenascin C Increases Phagocytosis Mediated by CD47 Loss of Function in Glioblastoma. [PDF]

, 2019
Glioblastomas (GBM) are highly infiltrated by myeloid-derived innate immune cells that contribute to the immunosuppressive nature of the brain tumor microenvironment (TME).
Gao, Peisong, Lal, Bachchu, Laterra, John, Lee, Richard S, Li, Jian Jian, Liu, Senquan, Lopez-Bertoni, Hernando, Ma, Ding, Wang, Shuyan, Wei, Shuang, Wilson, Mary Ann, Xia, Shuli, Ying, Mingyao, Zhan, Daqian, Zhang, Hao   +14 more
core   +2 more sources

Targeting CD47 [PDF]

Circulation Research, 2007
See related article, pages 712–720 Thrombospondin-1 (TSP-1) is a homotrimeric glycoprotein with multiple functional domains that serves as a key mediator of a number of diverse cellular and physiologic processes.1 TSP-1 is the major component of the α granule of platelets.
David J, Kaczorowski, Timothy R, Billiar
openaire   +2 more sources