Results 21 to 30 of about 35,706 (250)

Association between CD47 expression, clinical characteristics and prognosis in patients with advanced non‐small cell lung cancer

Cancer Medicine, 2020
Objective CD47 is an antiphagocytic molecule that contributes to tumor cell resistance in host immune surveillance. CD47 overexpression correlated with tumor progression and shorter survival in lung cancer.
Oscar Arrieta, Alejandro Aviles‐Salas, Mario Orozco‐Morales, Norma Hernández‐Pedro, Andrés F. Cardona, Luis Cabrera‐Miranda, Pedro Barrios‐Bernal, Giovanny Soca‐Chafre, Graciela Cruz‐Rico, María de Lourdes Peña‐Torres, Guadalupe Moncada‐Claudio, Laura‐Alejandra Ramirez‐Tirado   +11 more
doaj   +1 more source

Regulation of CD47 expression on CD14+ monocytes by interferon-α in PBC patients

Frontiers in Immunology, 2023
BackgroundPrimary biliary cholangitis (PBC) is a chronic intrahepatic cholestatic autoimmune liver disease characterized by inflammatory injury of small and medium-sized bile ducts in the liver.
Xi Su, Xi Su, Wenwen Jin, Wenwen Jin, Lizhi Liu, Zifei Zhu, Zifei Zhu, Cunyan Li, Cunyan Li   +8 more
doaj   +1 more source

An overview about erythrocyte membrane [PDF]

, 2010
© 2010 – IOS Press and the authors. All rights reservedIn the sixties and seventies, erythrocytes or red blood cells (RBCs) were extensively studied. Much has been learnt particularly concerning their metabolism and gas transporter function. In the past
Oliveira, Sofia de, Saldanha, Carlota
core   +1 more source

Identification of Schlafen-11 as a Target of CD47 Signaling That Regulates Sensitivity to Ionizing Radiation and Topoisomerase Inhibitors

Frontiers in Oncology, 2019
Knockdown or gene disruption of the ubiquitously expressed cell surface receptor CD47 protects non-malignant cells from genotoxic stress caused by ionizing radiation or cytotoxic chemotherapy but sensitizes tumors in an immune competent host to genotoxic
Sukhbir Kaur, Anthony L. Schwartz, David G. Jordan, David R. Soto-Pantoja, Bethany Kuo, Abdel G. Elkahloun, Lesley Mathews Griner, Craig J. Thomas, Marc Ferrer, Anish Thomas, Sai-Wen Tang, Vinodh N. Rajapakse, Yves Pommier, David D. Roberts   +13 more
doaj   +1 more source

Influence of sex steroids on the viability and CD11b, CD18 and CD47 expression of blood neutrophils from dairy cows in the last month of gestation [PDF]

, 2006
In the period around parturition, cows experience an increased susceptibility for the development of Escherichia coli mastitis. This increased susceptibility has been correlated with a decreased functionality of neutrophils.
Burvenich, Christian, De Ketelaere, Adelheid, Duchateau, Luc, Lamote, Inge, Meyer, Evelyne   +4 more
core   +4 more sources

Role of CD47 in Hematological Malignancies [PDF]

Journal of Hematology & Oncology, 2020
AbstractCD47, or integrin-associated protein, is a cell surface ligand expressed in low levels by nearly all cells of the body. It plays an integral role in various immune responses as well as autoimmunity, by sending a potent “don’t eat me” signal to prevent phagocytosis.
Entsar Eladl, Rosemarie Tremblay-LeMay, Nasrin Rastgoo, Rumina Musani, Wenming Chen, Aijun Liu, Hong Chang   +6 more
openaire   +4 more sources

The CD47-SIRPα Immune Checkpoint

Immunity, 2020
The cytotoxic activity of myeloid cells is regulated by a balance of signals that are transmitted through inhibitory and activating receptors. The Cluster of Differentiation 47 (CD47) protein, expressed on both healthy and cancer cells, plays a pivotal role in this balance by delivering a "don't eat me signal" upon binding to the Signal-regulatory ...
Meike E.W. Logtenberg, Ferenc A. Scheeren, Ton N. Schumacher   +2 more
openaire   +3 more sources

CD47 plays a critical role in T-cell recruitment by regulation of LFA-1 and VLA-4 integrin adhesive functions [PDF]

, 2013
CD47 plays an important but incompletely understood role in the innate and adaptive immune responses. CD47, also called integrin-associated protein, has been demonstrated to associate in cis with β1 and β3 integrins. Here we test the hypothesis that CD47
Alcaide P, Andrew D, Andrè Manica, Angela B. Schmider, Azcutia V, Barclay AN, Brittain JE, Brown E, Brown EJ, Charles A. Parkos, Chen C, Constantin G, Cooper D, de Vries HE, Dransfield I, Fortin G, Francis W. Luscinskas, Gail Newton, Han MH, Hogg N, Isenberg JS, Kevin J. Croce, Kim M, Lefort CT, Ley K, Lim YC, Lindberg FP, Luque A, Mandal AK, Marcie R. Williams, Mark H. Ginsberg, Matthew Routledge, McDonald JF, Melissa V. Turman, Miller LJ, Parkos CA, Quinn MT, Roy J. Soberman, Salas A, Shamri R, Shimaoka M, Sircar M, Smith A, Snapp KR, Stefanidakis M, Su X, Ticchioni M, Veronica Azcutia, William A. Frazier, Yang J   +49 more
core   +2 more sources

TIGIT/CD47 dual high expression predicts prognosis and is associated with immunotherapy response in lung squamous cell carcinoma

Thoracic Cancer, 2022
Background Recent studies indicated that T cell immunoreceptor with immunoglobulin and ITIM domains (TIGIT) and cluster of differentiation 47 (CD47) have emerged as new potential immunotherapy targets.
Yue Peng, Bin Qiu, Fengwei Tan, Jiachen Xu, Fenglong Bie, Huayu He, Lei Liu, He Tian, Guangyu Bai, Bolun Zhou, Yuan Li, Qilin Huai, Zhenlin Yang, Shugeng Gao   +13 more
doaj   +1 more source

Generation of a potent anti-PD-L1-CD47 bispecific antibody with a strong therapeutic and safety profile for cancer immunotherapy

Frontiers in Drug Discovery, 2023
Cell surface molecules PD-L1 and CD47 are potent inhibitors of adaptive and innate anti-cancer immunity. We sought to generate a safe, therapeutic, bispecific antibody specifically targeting, and blocking both PD-L1 and CD47 inhibitory activity.
Irene Tang, Lauren Schwimmer, Shenda Gu, Wei Wei Prior, Hieu Van Tran, Allan Chan, Anna McClain, Christopher C. Fraser, Chunyan Sun, Meimei Si, Guijiang Wang, Yunxia Zhao, Ning Zhang, Jiayu Fu, Mengxin Liu, Chuanzeng Cao, Shihao Chen   +16 more
doaj   +1 more source