Thrombospondin-1/CD47 interaction regulates Th17 and treg differentiation in psoriasis [PDF]
, 2019 Accumulating evidence on the role of Thrombospondin-1 (TSP-1) in the immune response has emerged during the last years. In spite of the importance of TSP-1 not only as anti-angiogenic factor but also as an immunomodulatory molecule, studies on the ...
Calzada, María J. +11 more
core +2 more sources
Menopause leads to elevated expression of macrophage-associated genes in the aging frontal cortex: rat and human studies identify strikingly similar changes. [PDF]
, 2012 BACKGROUND The intricate interactions between the immune, endocrine and central nervous systems shape the innate immune response of the brain. We have previously shown that estradiol suppresses expression of immune genes in the frontal cortex of ...
Carl Cotman +8 more
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BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeleton [PDF]
, 2014 BNIP3 is an atypical BH3-only member of the BCL-2 family of proteins with reported pro-death as well as pro-autophagic and cytoprotective functions, depending on the type of stress and cellular context.
Agostinis, P +8 more
core +2 more sources
Loss of CD47 alters CD8+ T cell activation in vitro and immunodynamics in mice
OncoImmunology, 2022 CD47 has established roles in the immune system for regulating macrophage phagocytosis and lymphocyte activation, with growing evidence of its cell-intrinsic regulatory roles in natural killer and CD8+ T cells.
Pulak R. Nath +6 more
doaj +1 more source
Signal regulatory protein alpha (SIRPα) regulates the homeostasis of CD103⁺CD11b⁺ DCs in the intestinal lamina propria [PDF]
, 2014 Signal regulatory protein alpha (SIRP alpha/CD172a) is a conserved transmembrane protein thought to play an inhibitory role in immune function by binding the ubiquitous ligand CD47.
Bain +48 more
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CD47 Augments Fas/CD95-mediated Apoptosis [PDF]
Journal of Biological Chemistry, 2005 Fas (CD95) mediates apoptosis of many cell types, but the susceptibility of cells to killing by Fas ligand and anti-Fas antibodies is highly variable. Jurkat T cells lacking CD47 (integrin-associated protein) are relatively resistant to Fas-mediated death but are efficiently killed by Fas ligand or anti-Fas IgM (CH11) upon expression of CD47.
Partha P, Manna +3 more
openaire +2 more sources
The convergence of radiation and immunogenic cell death signaling pathways. [PDF]
, 2012 Ionizing radiation (IR) triggers programmed cell death in tumor cells through a variety of highly regulated processes. Radiation-induced tumor cell death has been studied extensively in vitro and is widely attributed to multiple distinct mechanisms ...
Barcellos-Hoff, Mary H +4 more
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SIRP/CD47 signaling in neurological disorders [PDF]
Brain Research, 2015 Microglia play important roles in the process of neuronal injury and recovery. Numeous surface receptors have been described to regulate microglial activation. These receptors tightly mediate normal microglial functions including cell mobility, phagocytosis, and production of inflammatory mediators or trophic factors.
Haiyue, Zhang +4 more
openaire +2 more sources
CD47–SIRPα-targeted therapeutics: status and prospects [PDF]
Immuno-Oncology and Technology, 2022 CD47 is a "don't eat me" signal to phagocytes that is overexpressed on many tumor cells as a potential mechanism for immune surveillance evasion. CD47 and its interaction with signal-regulating protein alpha (SIRPα) on phagocytes is therefore a promising cancer target.
R. Maute, J. Xu, I.L. Weissman
openaire +3 more sources
Clinical and Translational MedicineAbstractCluster of differentiation 47 (CD47) occupies the outer membrane of human cells, where it binds to soluble and cell surface receptors on the same and other cells, sculpting their topography and resulting in a pleiotropic receptor‐multiligand interaction network.
Jeffrey S. Isenberg, Enrique Montero
openaire +3 more sources