Results 31 to 40 of about 38,316 (246)

Loss of CD47 alters CD8+ T cell activation in vitro and immunodynamics in mice

OncoImmunology, 2022
CD47 has established roles in the immune system for regulating macrophage phagocytosis and lymphocyte activation, with growing evidence of its cell-intrinsic regulatory roles in natural killer and CD8+ T cells.
Pulak R. Nath, Dipasmita Pal-Nath, Sukhbir Kaur, Arunkumar Gangaplara, Thomas J. Meyer, Margaret C Cam, David D. Roberts   +6 more
doaj   +1 more source

Signal regulatory protein alpha (SIRPα) regulates the homeostasis of CD103⁺CD11b⁺ DCs in the intestinal lamina propria [PDF]

, 2014
Signal regulatory protein alpha (SIRP alpha/CD172a) is a conserved transmembrane protein thought to play an inhibitory role in immune function by binding the ubiquitous ligand CD47.
Bain, Bain, Barclay, Barclay, Basu, Bimczok, Bogunovic, Cerovic, Cerovic, Coombes, del Rio, Fortin, Fukunaga, Goto, Inagaki, Iwamura, Kanazawa, Latour, Lewis, Lindberg, Liu, Lécuyer, Matozaki, Matteoli, Milling, Motegi, Naik, Okuzawa, Pabst, Persson, Persson, Raymond, Raymond, Saito, Satpathy, Schlitzer, Schraml, Schulz, Scott, Scott, Sun, Takai, Tamoutounour, Tomizawa, Varol, Waclavicek, Watchmaker, Welty, Westlund   +48 more
core   +2 more sources

Possible Implication of Red Blood Cells in the Prothrombotic Risk in Early Rheumatoid Arthritis [PDF]

, 2015
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that can be considered as a prothrombotic state1. A great number of studies have investigated the possible role of reactive oxygen species (ROS) in the etiology and pathogenesis of this ...
DI FRANCO, Manuela, DI LOLLO, ANNA CHIARA, Gambardella, Lucrezia, Malorni, Walter, Straface, Elisabetta, Valesini, Guido   +5 more
core   +1 more source

Osteoclast Fusion is Based on Heterogeneity Between Fusion Partners [PDF]

, 2014
Bone-resorbing osteoclasts are formed through fusion of mononucleated precursors. Their choice of partners during the fusion process remains unclear.
Delaissé, Jean-Marie, Hobolt-Pedersen, Anne-Sofie, Søe, Kent   +2 more
core   +1 more source

CD47 in Osteosarcoma: Correlation with Metastasis and Macrophage-Mediated Phagocytosis

Cells
CD47 is expressed on cell surfaces and acts as a “don’t eat me” signal by interacting with signal-regulatory protein-α on the macrophage surface. Some cancer cells express CD47 protein and can evade macrophage phagocytosis.
Yunmi Ko, Seog-Yun Park, Jong Woong Park, June Hyuk Kim, Hyun Guy Kang, Jun Ah Lee   +5 more
doaj   +1 more source

Rapid Dendritic Cell Activation and Resistance to Allotolerance Induction in Anti-CD154-Treated Mice Receiving CD47-Deficient Donor-Specific Transfusion

Cell Transplantation, 2014
CD47–SIRPα signaling plays an important role in regulating macrophage and dendritic cell (DC) activation. Here we investigated the role of CD47 expression on donor cells in tolerance induction by combined treatment with donor-specific transfusion (DST ...
Yuantao Wang, Hui Wang, Roderick Bronson, Yaowen Fu M.D., Ph.D., Yong-Guang Yang M.D., Ph.D.   +4 more
doaj   +1 more source

Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPα (signal regulatory protein-α) on phagocytes

Journal of Neuroinflammation, 2011
Background Traumatic injury to axons produces breakdown of axons and myelin at the site of the lesion and then further distal to this where Wallerian degeneration develops.
Reichert Fanny, Oldenborg Per-Arne, Liraz-Zaltsman Sigal, Gitik Miri, Rotshenker Shlomo   +4 more
doaj   +1 more source

Anti-CD47 antibody suppresses tumor growth and augments the effect of chemotherapy treatment in hepatocellular carcinoma [PDF]

, 2016
BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is often associated with metastasis and recurrence leading to a poor prognosis. Therefore, development of novel treatment regimens is urgently needed to improve the survival of HCC patients. In this study,
Chan, VSF, Cheng, YLB, Cheung, CH, Ching, HH, Lau, YT, Lee, KW, Lo, J, Lu, P, Ma, KF, Ng, IOL, So, TY   +10 more
core   +1 more source

CD47 is a direct target of SNAI1 and ZEB1 and its blockade activates the phagocytosis of breast cancer cells undergoing EMT

OncoImmunology, 2018
We report that CD47 was upregulated in different EMT-activated human breast cancer cells versus epithelial MCF7 cells. Overexpression of SNAI1 or ZEB1 in epithelial MCF7 cells activated EMT and upregulated CD47 while siRNA-mediated targeting of SNAI1 or ...
Muhammad Zaeem Noman, Kris Van Moer, Vanessa Marani, Robert M. Gemmill, Léon-Charles Tranchevent, Francisco Azuaje, Arnaud Muller, Salem Chouaib, Jean Paul Thiery, Guy Berchem, Bassam Janji   +10 more
doaj   +1 more source

Attenuation of CD47-SIRPα Signal in Cholangiocarcinoma Potentiates Tumor-Associated Macrophage-Mediated Phagocytosis and Suppresses Intrahepatic Metastasis

Translational Oncology, 2019
The involvement of chronic inflammation in cholangiocarcinoma (CCA) progression is well established. Cluster of differentiation 47 (CD47) is mutually expressed in various cancers and serves as a protective signal for phagocytic elimination.
Kulthida Vaeteewoottacharn, Ryusho Kariya, Phattarin Pothipan, Sawako Fujikawa, Chawalit Pairojkul, Sakda Waraasawapati, Kazuhiko Kuwahara, Chaisiri Wongkham, Sopit Wongkham, Seiji Okada   +9 more
doaj   +1 more source