Results 31 to 40 of about 36,599 (239)

Signal regulatory protein alpha (SIRPα) regulates the homeostasis of CD103⁺CD11b⁺ DCs in the intestinal lamina propria [PDF]

, 2014
Signal regulatory protein alpha (SIRP alpha/CD172a) is a conserved transmembrane protein thought to play an inhibitory role in immune function by binding the ubiquitous ligand CD47.
Bain, Bain, Barclay, Barclay, Basu, Bimczok, Bogunovic, Cerovic, Cerovic, Coombes, del Rio, Fortin, Fukunaga, Goto, Inagaki, Iwamura, Kanazawa, Latour, Lewis, Lindberg, Liu, Lécuyer, Matozaki, Matteoli, Milling, Motegi, Naik, Okuzawa, Pabst, Persson, Persson, Raymond, Raymond, Saito, Satpathy, Schlitzer, Schraml, Schulz, Scott, Scott, Sun, Takai, Tamoutounour, Tomizawa, Varol, Waclavicek, Watchmaker, Welty, Westlund   +48 more
core   +2 more sources

Single vesicle analysis of CD47 association with integrins and tetraspanins on extracellular vesicles released by T lymphoblast and prostate carcinoma cells

Journal of Extracellular Vesicles, 2022
CD47 regulates the trafficking of specific coding and noncoding RNAs into extracellular vesicles (EVs), and the RNA contents of CD47+ EVs differ from that of CD63+ EVs released by the same cells.
Sukhbir Kaur, Ferenc Livak, George Daaboul, Leif Anderson, David D. Roberts   +4 more
doaj   +1 more source

BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeleton [PDF]

, 2014
BNIP3 is an atypical BH3-only member of the BCL-2 family of proteins with reported pro-death as well as pro-autophagic and cytoprotective functions, depending on the type of stress and cellular context.
Agostinis, P, Garg, AD, Krysko, Dmitri, Maes, H, Nys, K, Rillaerts, K, Van Eygen, S, Vandenabeele, Peter, Verfaillie, T   +8 more
core   +2 more sources

CD47 restricts antiviral function of alveolar macrophages during influenza virus infection

iScience, 2022
Summary: CD47 is an ubiquitously expressed surface molecule with significant impact on immune responses. However, its role for antiviral immunity is not fully understood. Here, we revealed that the expression of CD47 on immune cells seemed to disturb the
Christina Wenzek, Philine Steinbach, Florian Wirsdörfer, Kathrin Sutter, Julia D. Boehme, Robert Geffers, Robert Klopfleisch, Dunja Bruder, Verena Jendrossek, Jan Buer, Astrid M. Westendorf, Torben Knuschke   +11 more
doaj   +1 more source

CD47 in Osteosarcoma: Correlation with Metastasis and Macrophage-Mediated Phagocytosis

Cells
CD47 is expressed on cell surfaces and acts as a “don’t eat me” signal by interacting with signal-regulatory protein-α on the macrophage surface. Some cancer cells express CD47 protein and can evade macrophage phagocytosis.
Yunmi Ko, Seog-Yun Park, Jong Woong Park, June Hyuk Kim, Hyun Guy Kang, Jun Ah Lee   +5 more
doaj   +1 more source

Anti-CD47 antibody suppresses tumor growth and augments the effect of chemotherapy treatment in hepatocellular carcinoma [PDF]

, 2016
BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is often associated with metastasis and recurrence leading to a poor prognosis. Therefore, development of novel treatment regimens is urgently needed to improve the survival of HCC patients. In this study,
Chan, VSF, Cheng, YLB, Cheung, CH, Ching, HH, Lau, YT, Lee, KW, Lo, J, Lu, P, Ma, KF, Ng, IOL, So, TY   +10 more
core   +1 more source

Regulation of CD47 expression in cancer cells

Translational Oncology, 2020
CD47 is overexpressed in various types of cancers and it can directly bind with SIRPα, which is mainly located on macrophages. The binding of CD47-SIRPα transmits a “don't eat me” signal, which can prevent cancer cells from immune clearance.
Can-Yu Huang, Zi-Han Ye, Mu-Yang Huang, Jin-Jian Lu   +3 more
doaj   +1 more source

Targeting the CD47/thrombospondin-1 signaling axis regulates immune cell bioenergetics in the tumor microenvironment to potentiate antitumor immune response

Journal for ImmunoTherapy of Cancer, 2022
Background CD47 is an integral membrane protein that alters adaptive immunosurveillance when bound to the matricellular glycoprotein thrombospondin-1 (TSP1). We examined the impact of the CD47/TSP1 signaling axis on melanoma patient response to anti-PD-1
Wei Zhang, Masaki Terabe, Lance D Miller, Mitra Kooshki, Pierre L Triozzi, Elizabeth R Stirling, Adam S Wilson, Liliya M Yamaleyeva, Martha A Alexander-Miller, David R Soto-Pantoja   +9 more
doaj   +1 more source

Possible Implication of Red Blood Cells in the Prothrombotic Risk in Early Rheumatoid Arthritis [PDF]

, 2015
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that can be considered as a prothrombotic state1. A great number of studies have investigated the possible role of reactive oxygen species (ROS) in the etiology and pathogenesis of this ...
DI FRANCO, Manuela, DI LOLLO, ANNA CHIARA, Gambardella, Lucrezia, Malorni, Walter, Straface, Elisabetta, Valesini, Guido   +5 more
core   +1 more source

Attenuation of CD47-SIRPα Signal in Cholangiocarcinoma Potentiates Tumor-Associated Macrophage-Mediated Phagocytosis and Suppresses Intrahepatic Metastasis

Translational Oncology, 2019
The involvement of chronic inflammation in cholangiocarcinoma (CCA) progression is well established. Cluster of differentiation 47 (CD47) is mutually expressed in various cancers and serves as a protective signal for phagocytic elimination.
Kulthida Vaeteewoottacharn, Ryusho Kariya, Phattarin Pothipan, Sawako Fujikawa, Chawalit Pairojkul, Sakda Waraasawapati, Kazuhiko Kuwahara, Chaisiri Wongkham, Sopit Wongkham, Seiji Okada   +9 more
doaj   +1 more source