Evidence that the degree of band 3 phosphorylation modulates human erythrocytes nitric oxide efflux – in vitro model of hyperfibrinogenemia [PDF]
, 2011 © 2011 – IOS Press and the authors. All rights reservedRecent evidence has shown that plasma fibrinogen, a major cardiovascular risk factor, interacts with the erythrocyte membrane and acts to influence blood flow via erythrocyte nitric oxide (NO ...
Almeida, J. P. Lopes de +2 more
core +1 more source
Anti-CD47 antibody suppresses tumor growth and augments the effect of chemotherapy treatment in hepatocellular carcinoma [PDF]
, 2016 BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) is often associated with metastasis and recurrence leading to a poor prognosis. Therefore, development of novel treatment regimens is urgently needed to improve the survival of HCC patients. In this study,
Chan, VSF +10 more
core +1 more source
CD47 in Osteosarcoma: Correlation with Metastasis and Macrophage-Mediated Phagocytosis
CellsCD47 is expressed on cell surfaces and acts as a “don’t eat me” signal by interacting with signal-regulatory protein-α on the macrophage surface. Some cancer cells express CD47 protein and can evade macrophage phagocytosis.
Yunmi Ko +5 more
doaj +1 more source
Cell Transplantation, 2014 CD47–SIRPα signaling plays an important role in regulating macrophage and dendritic cell (DC) activation. Here we investigated the role of CD47 expression on donor cells in tolerance induction by combined treatment with donor-specific transfusion (DST ...
Yuantao Wang +4 more
doaj +1 more source
CD47 is highly expressed in gliomas and targeting CD47 is a promising therapeutic strategy
European Journal of Inflammation, 2021 Gliomas are very malignant brain tumors that are difficult to treat. CD47 is an antiphagocytic molecule that binds to SIPRα on phagocytes. It is overexpressed on the plasma membranes of multiple human tumor cell types and is an important diagnostic and ...
Jiaying Yang +5 more
doaj +1 more source
Possible Implication of Red Blood Cells in the Prothrombotic Risk in Early Rheumatoid Arthritis [PDF]
, 2015 Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that can be considered as a prothrombotic state1. A great number of studies have investigated the possible role of reactive oxygen species (ROS) in the etiology and pathogenesis of this ...
DI FRANCO, Manuela +5 more
core +1 more source
A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer [PDF]
Nature Communications, 2017 AbstractCD47 is a cell surface molecule that inhibits phagocytosis of cells that express it by binding to its receptor, SIRPα, on macrophages and other immune cells. CD47 is expressed at different levels by neoplastic and normal cells. Here, to reveal mechanisms by which different neoplastic cells generate this dominant ‘don’t eat me’ signal, we ...
Paola A. Betancur +17 more
openaire +5 more sources
Exosomes: Versatile Nano Mediators of Immune Regulation. [PDF]
, 2019 One of many types of extracellular vesicles (EVs), exosomes are nanovesicle structures that are released by almost all living cells that can perform a wide range of critical biological functions.
Cacalano, Nicholas A +4 more
core +1 more source
Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers
Advanced Functional Materials, EarlyView.A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley +1 more source
OncoImmunology, 2018 We report that CD47 was upregulated in different EMT-activated human breast cancer cells versus epithelial MCF7 cells. Overexpression of SNAI1 or ZEB1 in epithelial MCF7 cells activated EMT and upregulated CD47 while siRNA-mediated targeting of SNAI1 or ...
Muhammad Zaeem Noman +10 more
doaj +1 more source