Results 61 to 70 of about 38,316 (246)

A novel anti-CD47 antibody with therapeutic potential for NK/T-cell lymphoma

Human Vaccines & Immunotherapeutics
NK/T-cell lymphoma (NKTCL) is a rare type of non-Hodgkin lymphoma (NHL). Although L-asparaginase-based chemotherapy has significantly improved survival in early-stage patients, the prognosis is poor in advanced and relapsed or refractory patients.
Liping Qin, Yajun Li, Ruolan Zeng, Yizi He, Xiaoyan Chen, Ling Xiao, Hui Zhou   +6 more
doaj   +1 more source

CD47 (Cluster of differentiation 47): an anti-phagocytic receptor with a multitude of signaling functions

Animal Cells and Systems, 2020
CD47 is a tumor-associated antigen best known for its ability to bind counter-receptors on the surface of professional phagocytes as an immune-evasion strategy.
Pascal Leclair, Chinten James Lim
doaj   +1 more source

Targeting CD47-SIRPa axis shows potent preclinical anti-tumor activity as monotherapy and synergizes with PARP inhibition

npj Precision Oncology, 2023
The objective was to correlate CD47 gene expression with resistance to immune checkpoint inhibitors (ICI) in tumor tissue of gynecological cancer (GC).
Hussein Al-Sudani, Ying Ni, Philip Jones, Huseyin Karakilic, Lei Cui, Lisa D. S. Johnson, Peter G. Rose, Alexander Olawaiye, Robert P. Edwards, Robert A. Uger, Gloria H. Y. Lin, Haider Mahdi   +11 more
doaj   +1 more source

Ir(III) Complexes Convert Cold to Hot Tumors via Ferroptosis/Necroptosis‐Driven Immunogenic Cell Death and Photosensitized CD47 Downregulation

Advanced Science, EarlyView.
Red‐light‐activated Ir1 overcomes hypoxia tolerance and adapts to the immunosuppressive tumor microenvironment, converting immunologically cold tumors into inflamed hot microenvironments. This conversion is driven by synergistic induction of immunogenic cell death through coordinated ferroptosis‐necroptosis pathways and spatiotemporally controlled ...
Long‐Bo Yu, Peng Wang, Qing‐Hua Shen, Qi‐Xin Guan, Zhi‐Yuan Li, Ying‐Ying Han, Xin‐Yi Zhang, Qing‐Yuan Hu, Cai‐Ping Tan   +8 more
wiley   +1 more source

Ubiquitination of CD47 Regulates Innate Anti‐Tumor Immune Response

Advanced Science
In addition to adaptive immune checkpoint of PD‐1/PD‐L1, the innate immune checkpoint SIRPα/CD47 plays an important role in regulation of tumor immune escape. However, the mechanism of CD47 ubiquitination on tumor immune escape remains unclear.
Qian Gou, Bingjun Yan, Yalan Duan, Yilei Guo, Jing Qian, Juanjuan Shi, Yongzhong Hou   +6 more
doaj   +1 more source

Immune vulnerability of ovarian cancer stem-like cells due to low CD47 expression is protected by surrounding bulk tumor cells

OncoImmunology, 2020
Recurrence of advanced epithelial ovarian cancer is common despite optimal surgical debulking and initial favorable responses to chemotherapy. Evidences suggest that cancer stem cells (CSCs) have inherent resistance to conventional therapies such as ...
Chih-Long Chang, Chao-Chih Wu, Yun-Ting Hsu, Yi-Chiung Hsu   +3 more
doaj   +1 more source

Macrophage transactivation for chemokine production identified as a negative regulator of granulomatous inflammation using agent-based modeling [PDF]

, 2018
Cellular activation in trans by interferons, cytokines and chemokines is a commonly recognized mechanism to amplify immune effector function and limit pathogen spread. However, an optimal host response also requires that collateral damage associated with
Andrews, Paul S., Beattie, Lynette, Hoehme, Stefan, Kaye, Paul M., Moore, John W. J., Moyo, Daniel, Sampson, Adam T., Sawtell, Amy, Timmis, Jon   +8 more
core   +5 more sources

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen, Rui Li, Yong She, Xuefei Liu, Yuanyang Huang, Yongling Ji, Keying Chen, Zhengbo Song, Runzhe Chen, Xuan Li, Qi Zhao, Qixun Chen, Ming Chen   +12 more
wiley   +1 more source

Deletion of CD47 from Schwann cells and macrophages hastens myelin disruption/dismantling and scavenging in Schwann cells and augments myelin debris phagocytosis in macrophages

Journal of Neuroinflammation, 2023
Background Myelin that surrounds axons breaks in trauma and disease; e.g., peripheral nerve and spinal cord injuries (PNI and SCI) and multiple sclerosis (MS).
Miri Gitik, Gerard Elberg, Fanny Reichert, Michael Tal, Shlomo Rotshenker   +4 more
doaj   +1 more source

Irradiation to Improve the Response to Immunotherapeutic Agents in Glioblastomas. [PDF]

, 2019
PurposeGlioblastoma (GBM) remains an incurable disease despite extensive treatment with surgical resection, irradiation, and temozolomide. In line with many other forms of aggressive cancers, GBM is currently under consideration as a target for ...
Kaprealian, Tania, Lee, Mi-Heon, McBride, William H, Nesseler, Jean Philippe, Nickers, Philippe, Niclou, Simone P, Schaue, Dorthe   +6 more
core