Results 81 to 90 of about 36,599 (239)
Cell Transplantation, 2011 Signal regulatory protein α (SIRPα) is a critical immune inhibitory receptor on macrophages, and its interaction with CD47 prevents autologous phagocytosis.
Chunfeng Wang +6 more
doaj +1 more source
Advanced Science, EarlyView.This study reveals that ARID3A in macrophages can transcriptionally regulate the THBS1‐CD47 axis after heart transplantation (HT), thereby inducing activated neutrophils to release NETs through the p38 MAPK signaling pathway. The itaconate derivative 4‐OI can inhibit ARID3A in macrophages and promote the accumulation of antioxidant factors, thereby ...
Hao Tian +7 more
wiley +1 more source
Advanced Science, EarlyView.In this study, an “all‐in‐one” engineered anaerobic bacterial system (PDAEcN/COS) is developed for the treatment of immunologically “cold” TNBC. This nanoplatform is capable of colonizing tumor cell surfaces and implementing “self‐blocking” of immune checkpoints, while simultaneously suppressing tumor cells' “don't eat me” signals and delivering “eat ...
Xuanxiang Zhai +6 more
wiley +1 more source
CD47 knockout mice exhibit improved recovery from spinal cord injury
Neurobiology of Disease, 2011 Recent data have implicated thrombospondin-1 (TSP-1) signaling in the acute neuropathological events that occur in microvascular endothelial cells (ECs) following spinal cord injury (SCI) (Benton et al., 2008b).
Scott A. Myers +7 more
doaj +1 more source
Macrophage transactivation for chemokine production identified as a negative regulator of granulomatous inflammation using agent-based modeling [PDF]
, 2018 Cellular activation in trans by interferons, cytokines and chemokines is a commonly recognized mechanism to amplify immune effector function and limit pathogen spread. However, an optimal host response also requires that collateral damage associated with
Andrews, Paul S. +8 more
core +5 more sources
Advanced Science, EarlyView.Coordinating therapy with gene expression kinetics emerges as a key strategy for maximizing nanomedicine efficacy in aggressive cancers. A hybrid nanocarrier delivering HSP70‐targeting siRNA demonstrates this chronotherapeutic principle through systematic cellular profiling.
Tianliang Fang +6 more
wiley +1 more source
Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation [PDF]
, 2015 Leukocyte extravasation is one of the essential and first steps during the initiation of inflammation. Therefore, a better understanding of the key molecules that regulate this process may help to develop novel therapeutics for treatment of inflammation ...
Alcaide, P +3 more
core +11 more sources
The Sixth Annual Translational Stem Cell Research Conference of the New York Stem Cell Foundation [PDF]
, 2012 The New York Stem Cell Foundation's "Sixth Annual Translational Stem Cell Research Conference" convened on October 11-12, 2011 at the Rockefeller University in New York City.
de Peppo, Giuseppe Maria +14 more
core +1 more source
Red Blood Cell‐Derived Exosomal miR‐93‐5p Promotes Lung Cancer Progression through PTEN Suppression
Advanced Science, EarlyView.Red blood cell (RBC)‐derived exosomal miR‐93‐5p is elevated in lung cancer patients and correlates with poor outcomes. Exosomal miR‐93‐5p suppresses PTEN in cancer cells, enhancing proliferation, migration, and invasion. In mouse models, therapeutic inhibition with ASO‐miR‐93 5p reduces tumor growth, highlighting a bidirectional tumor‐RBC‐tumor axis ...
Ning Li +4 more
wiley +1 more source
Keeping Off the Weight with DCs [PDF]
, 2015 Long studied as modulators of insulin sensitivity, adipose tissue immune cells have recently been implicated in regulating fat mass and weight gain. In this issue of Immunity, Reisner and colleagues (2015) report that ablation of perforin-expressing ...
Antoniou, Mark (R17772) +3 more
core +1 more source