Results 11 to 20 of about 50,598 (255)

PET imaging of colon cancer CD73 expression using cysteine site-specific 89Zr-labeled anti-CD73 antibody

Scientific Reports
CD73 is a cell-surface ectoenzyme that hydrolyzes the conversion of extracellular adenosine monophosphate to adenosine, which in turn can promote resistance to immune checkpoint blockade therapy.
Kyung-Ho Jung, Mina Kim, Hye Jin Jung, Hyun Jung Koo, Jung-Lim Kim, Hyunjong Lee, Kyung-Han Lee   +6 more
doaj   +3 more sources

Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73^- Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes [PDF]

Cells, 2020
The ectonucleotidases CD39 and CD73 regulate immune responses by balancing extracellular ATP and adenosine in inflammation and are likely to be involved in the pathophysiology of COVID-19.
Parimah Ahmadi, Philip Hartjen, Matin Kohsar, Silke Kummer, Stefan Schmiedel, Jan-Hendrik Bockmann, Anahita Fathi, Samuel Huber, Friedrich Haag, Julian Schulze zur Wiesch   +9 more
doaj   +3 more sources

CD73 Promotes Chronic Lymphocytic Leukemia

Cancers, 2022
The ecto-nucleotidase CD73 is an important immune checkpoint in tumor immunity that cooperates with CD39 to hydrolyze pro-inflammatory extracellular ATP into immunosuppressive adenosine. While the role of CD73 in immune evasion of solid cancers is well established, its role in leukemia remains unclear.
David Allard, Pavel Chrobak, Yacine Bareche, Bertrand Allard, Priscilla Tessier, Marjorie A. Bergeron, Nathalie A. Johnson, John Stagg   +7 more
openaire   +2 more sources

Host CD73 impairs anti-tumor immunity [PDF]

OncoImmunology, 2012
The enzymatic activity of CD73 produces immune-suppressing adenosine. In CD73 deficient hosts, tumor growth and tumor infiltration by Tregs and type 2 immunosuppressive macrophages is reduced. Pharmacological inhibition of CD73 in wild-type mice has similar tumor-suppressing effects. Host CD73 on leukocytes and endothelial cells is thus detrimental for
Salmi, Marko, Jalkanen, Sirpa
openaire   +4 more sources

CD73‐generated adenosine promotes osteoblast differentiation [PDF]

Journal of Cellular Physiology, 2012
AbstractCD731 is a GPI‐anchored cell surface protein with ecto‐5′‐nucleotidase enzyme activity that plays a crucial role in adenosine production. While the roles of adenosine receptors (AR) on osteoblasts and osteoclasts have been unveiled to some extent, the roles of CD73 and CD73‐generated adenosine in bone tissue are largely unknown. To address this
Masahide, Takedachi, Hiroyuki, Oohara, Brenda J, Smith, Mitsuyoshi, Iyama, Mariko, Kobashi, Kenichiro, Maeda, Courtney L, Long, Mary B, Humphrey, Barbara J, Stoecker, Satoru, Toyosawa, Linda F, Thompson, Shinya, Murakami   +11 more
openaire   +2 more sources

Fluorescent Probes for Ecto-5′-nucleotidase (CD73) [PDF]

ACS Medicinal Chemistry Letters, 2020
Ecto-5'-nucleotidase (CD73) catalyzes the hydrolysis of AMP to anti-inflammatory, immunosuppressive adenosine. It is expressed on vascular endothelial, epithelial, and also numerous cancer cells where it strongly contributes to an immunosuppressive microenvironment.
Constanze C. Schmies, Georg Rolshoven, Riham M. Idris, Karolina Losenkova, Christian Renn, Laura Schäkel, Haneen Al-Hroub, Yulu Wang, Francesca Garofano, Ingo G. H. Schmidt-Wolf, Herbert Zimmermann, Gennady G. Yegutkin, Christa E. Müller   +12 more
openaire   +3 more sources

Graft-versus-host disease is enhanced by selective CD73 blockade in mice. [PDF]

PLoS ONE, 2013
CD73 functions as an ecto-5'-nucleotidase to produce extracellular adenosine that has anti-inflammatory and immunosuppressive activity. We here demonstrate that CD73 helps control graft-versus-host disease (GVHD) in mouse models.
Long Wang, Jie Fan, Siqi Chen, Yi Zhang, Tyler J Curiel, Bin Zhang   +5 more
doaj   +1 more source

The CD73 immune checkpoint promotes tumor cell metabolic fitness

eLife, 2023
CD73 is an ectonucleotidase overexpressed on tumor cells that suppresses anti-tumor immunity. Accordingly, several CD73 inhibitors are currently being evaluated in the clinic, including in large randomized clinical trials.
David Allard, Isabelle Cousineau, Eric H Ma, Bertrand Allard, Yacine Bareche, Hubert Fleury, John Stagg   +6 more
doaj   +1 more source

Metabolic signaling directs the reciprocal lineage decisions of αβ and γδ T cells [PDF]

, 2018
Wiring metabolic signaling circuits in thymocytes Cell differentiation is often accompanied by metabolic changes. Yang et al. report that generation of double-positive (DP) thymocytes from double-negative (DN) cells coincides with dynamic regulation of ...
Awad, Walid, Blanco, Daniel Bastardo, Chen, Wenan, Chen, Xiang, Cheng, Changde, Chi, Hongbo, Dash, Pradyot, Dhungana, Yogesh, Easton, John, Guo, Xi-Zhi J., Kc, Anil, Neale, Geoffrey, Rosencrance, Celeste, Thomas, Paul G., Yang, Kai   +14 more
core   +1 more source

The first CD73-instructed supramolecular hydrogel [PDF]

Journal of Colloid and Interface Science, 2015
Enzymatic supramolecular hydrogelation is a simple, controllable, and novel strategy for preparation of soft colloidal materials, which allows the integration of self-assembly with enzyme associated biological processes. The development of more enzymes involve in hydrogelation is a subject of developing useful soft colloids. In this work, an ectoenzyme,
Dongdong Wu, Xuewen Du, Junfeng Shi, Jie Zhou, Ning Zhou, Bing Xu   +5 more
openaire   +2 more sources