Results 51 to 60 of about 69,003 (290)

CD80 and CTLA-4 as diagnostic and prognostic markers in adult-onset minimal change disease: a retrospective study [PDF]

PeerJ, 2018
Background Minimal change disease (MCD) is a form of idiopathic nephrotic syndrome. Compared to children, adult-onset MCD patients are reported to have delayed responses to glucocorticoid treatment.
Bing Zhao, Hui Han, Junhui Zhen, Xiaowei Yang, Jin Shang, Liang Xu, Rong Wang   +6 more
doaj   +2 more sources

Water‐Activated Phospholipid Phase‐Separation Gel as an Immunomodulatory Anti‐Adhesion Barrier for Postoperative Adhesion Prevention

Advanced Healthcare Materials, EarlyView.
A water‐activated phospholipid phase‐separation gel is repurposed as a drug‐free surgical barrier for postoperative adhesion prevention. Propylene glycol promotes rapid lamellar gel reinforcement, prolonged local retention, and tissue coverage, while phosphatidylcholine‐mediated immunomodulation suppresses inflammatory and fibrotic responses. This dual‐
Jong‐Ju Lee, Yulseung Sung, Yeji Kim, Heesang Yang, Suyeon Pyo, Byeol Yun, Sung‐Joo Hwang   +6 more
wiley   +1 more source

Epithelial CD80 promotes immune surveillance of colonic preneoplastic lesions and its expression is increased by oxidative stress through STAT3 in colon cancer cells

Journal of Experimental & Clinical Cancer Research, 2019
Background One of the most potent costimulatory molecules involved in the recognition and killing of tumor cells is CD80. However, its role and the molecular mechanisms regulating its expression in sporadic colorectal carcinogenesis remain elusive. Here,
Chiara Marchiori, Melania Scarpa, Andromachi Kotsafti, Susan Morgan, Matteo Fassan, Vincenza Guzzardo, Andrea Porzionato, Imerio Angriman, Cesare Ruffolo, Stefania Sut, Stefano Dall’Acqua, Romeo Bardini, Raffaele De Caro, Carlo Castoro, Marco Scarpa, Ignazio Castagliuolo   +15 more
doaj   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Evaluation of Some Immunological Markers in Pregnant Women Infected with Cytomegalovirus in Kirkuk, Iraq

Medical Journal of Babylon
Background: Both innate and adaptive immunological responses may be activated by cytomegalovirus (CMV) infection, leading to significant reactions later in the course of the illness. Innate immune components, which react fast and nonspecifically, combine
Zena Muayad Nooruldeen, Mohammed Yawoz Nooruldeen   +1 more
doaj   +1 more source

Cytotoxic T lymphocyte-associated antigen-4-Ig (CTLA-4-Ig) suppresses Staphylococcus aureus-induced CD80, CD86, and pro-inflammatory cytokine expression in human B cells

Arthritis Research & Therapy, 2020
Background Cytotoxic T lymphocyte-associated antigen-4-Ig (CTLA-4-Ig) competes with CD28 for binding CD80/CD86 on antigen-presenting cells (APCs) to limit T cell activation.
Po-Chun Liu, Chih-Tai Ssu, Yen-Po Tsao, Teh-Ling Liou, Chang-Youh Tsai, Chung-Tei Chou, Ming-Han Chen, Chuen-Miin Leu   +7 more
doaj   +1 more source

Anisotropic Masked Mycobacterium Potentiates Amplified Antitumor Trained Immunity via Spleen Targeting and Myelopoiesis Conversion

Advanced Materials, EarlyView.
An engineered Trojan Mycobacterium, developed via a “peeling‐off and masking‐up” strategy, functions as a powerful splenic myelopoiesis converter. This spleen‐targeted nanomedicine induces trained immunity to reprogram immunosuppressive myeloid reservoirs into antitumoral effectors.
Jin‐Ho Choi, Sang Nam Lee, Jang Hun Heo, Soyoung Park, Sei Hyun Park, Yong Taik Lim   +5 more
wiley   +1 more source

DataSheet1_Molecular and Clinical Characterization of CD80 Expression via Large-Scale Analysis in Breast Cancer.docx

, 2022
Cancer immunotherapy is emerging as a novel promising therapy option for cancer patients. Despite the critical role of CD80 in the regulation of immune responses, the expression and biological functions of CD80 in breast cancer remain unknown.
Shengze Zhang (12904991), Jianqiang Shao (12904988), Qin Zhang (58638), Chaowei Gao (12904985), Zunyi Wang (12904994), Peng Wang (34436)   +5 more
core   +1 more source

Photoacoustic Nanotagging for In Vivo Tracking and Optimization of Macrophage Immunotherapy in Solid Tumors

Advanced Materials, EarlyView.
Macrophage‐based immunotherapy for solid tumors is limited by poor tracking of cell localization and persistence. This study introduces nanotagged macrophages enabling near‐infrared photoacoustic imaging for real‐time monitoring. IFNγ‐conjugated tags enhance antitumor polarization without harming viability.
Seoyoon Song, Melissa Cadena, Myeongsoo Kim, Euisuk Chung, Jeungyoon Lee, Zlata Brushevich, Seonghun Shin, Paul S. Pelkowski, Stanislav Y. Emelianov   +8 more
wiley   +1 more source

Autoantibodies against CD80 in patients with COPD

Clinical & Translational Immunology, 2016
Chronic obstructive pulmonary disease (COPD) is an inflammation disorder and possibly an autoimmune disease. The components of the autoimmune response in the circulatory system are of considerable interest to clinicians. Because aberrations of costimulation status have been noted in COPD, the presence of autoantibodies to B7 costimulatory factor CD80 ...
Luo, Xu Min, Liu, Xin Yan, Tang, Ji Hong, Yang, Wei, Ni, Zhen Hua, Chen, Qing Ge, Wang, Xiongbiao   +6 more
openaire   +2 more sources