Results 51 to 60 of about 65,297 (255)

CD80 and CTLA-4 as diagnostic and prognostic markers in adult-onset minimal change disease: a retrospective study [PDF]

PeerJ, 2018
Background Minimal change disease (MCD) is a form of idiopathic nephrotic syndrome. Compared to children, adult-onset MCD patients are reported to have delayed responses to glucocorticoid treatment.
Bing Zhao, Hui Han, Junhui Zhen, Xiaowei Yang, Jin Shang, Liang Xu, Rong Wang   +6 more
doaj   +2 more sources

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Epithelial CD80 promotes immune surveillance of colonic preneoplastic lesions and its expression is increased by oxidative stress through STAT3 in colon cancer cells

Journal of Experimental & Clinical Cancer Research, 2019
Background One of the most potent costimulatory molecules involved in the recognition and killing of tumor cells is CD80. However, its role and the molecular mechanisms regulating its expression in sporadic colorectal carcinogenesis remain elusive. Here,
Chiara Marchiori, Melania Scarpa, Andromachi Kotsafti, Susan Morgan, Matteo Fassan, Vincenza Guzzardo, Andrea Porzionato, Imerio Angriman, Cesare Ruffolo, Stefania Sut, Stefano Dall’Acqua, Romeo Bardini, Raffaele De Caro, Carlo Castoro, Marco Scarpa, Ignazio Castagliuolo   +15 more
doaj   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

Genetic distance between mammalian CTLA4, B7.1/CD80 and B7.2/CD86. [PDF]

, 2016
The percentage of amino acid identities between pairwise comparisons are shown as a matrix for CTLA4 (A), CD80 (B) and CD86 (C). The distribution of pairwise identities was calculated in segments of 4% (D) and illustrates higher amino acid conservation ...
Wiebke Baars (3170967), Armin Saalmüller (318023), Wilhelm Gerner (582150), Annegret Wünsch (3170970), Nadja Herbach (347371), Reinhard Schwinzer (193143), Eckhard Wolf (39870), Barbara Kessler (133280), Andrea Bähr (829917), Tobias Käser (3170976), Stephanie C. Talker (3170973), Hiroshi Nagashima (406141), Mayuko Kurome (133277), Elisabeth Kemter (247006), Kirsti Witter (431124), Nikolai Klymiuk (814627)   +15 more
core   +1 more source

Evaluation of Some Immunological Markers in Pregnant Women Infected with Cytomegalovirus in Kirkuk, Iraq

Medical Journal of Babylon
Background: Both innate and adaptive immunological responses may be activated by cytomegalovirus (CMV) infection, leading to significant reactions later in the course of the illness. Innate immune components, which react fast and nonspecifically, combine
Zena Muayad Nooruldeen, Mohammed Yawoz Nooruldeen   +1 more
doaj   +1 more source

Cytotoxic T lymphocyte-associated antigen-4-Ig (CTLA-4-Ig) suppresses Staphylococcus aureus-induced CD80, CD86, and pro-inflammatory cytokine expression in human B cells

Arthritis Research & Therapy, 2020
Background Cytotoxic T lymphocyte-associated antigen-4-Ig (CTLA-4-Ig) competes with CD28 for binding CD80/CD86 on antigen-presenting cells (APCs) to limit T cell activation.
Po-Chun Liu, Chih-Tai Ssu, Yen-Po Tsao, Teh-Ling Liou, Chang-Youh Tsai, Chung-Tei Chou, Ming-Han Chen, Chuen-Miin Leu   +7 more
doaj   +1 more source

TME/NIR Dual‐Responsive Zinc‐Based Targeted Nanoagonist for Multimodal Amplification of STING‐Mediated Cancer Immunotherapy

Advanced Science, EarlyView.
A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu, Jiawei Wang, Wei Zhang, Zhixuan Wu, Jing Chen, Yujing He, Xiyue Duan, Yaoting He, Xin Xin, Haoyi Xiang, Yijing Wang, Chengwei Wu, Yang Yi, Qing Meng, Yuqian Qiao, Kui Cheng, Xiaojun Long, Zhangfa Song   +17 more
wiley   +1 more source

CD80 and CD86 polymorphisms in populations of various ancestries: 5 new CD80 promoter alleles [PDF]

, 2012
CD80 and CD86 are closely linked genes on chromosome 3 that code for glycoproteins of the immunoglobulin superfamily, expressed on the surface of antigen-presenting cells.
Pincerati, Marcia Regina, Tsuneto, Luiza Tamie, Dalla-Costa, Ricardo, Ricardo Dalla-Costa, Márcia Holsbach Beltrame, Luiza Tamie Tsuneto, Beltrame, Marcia Holsbach, Koehler, Karen Francine, Eleidi Alice Chautard-Freire-Maia, Chautard-Freire-Maia, Eleidi Alice, Wassem, Roseli, Karen Francine Köhler, Petzl-Erler, Maria Luiza, Márcia Regina Pincerati, Roseli Wassem, Maria Luiza Petzl-Erler   +15 more
core   +1 more source

Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma

Advanced Science, EarlyView.
Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han, Jinpeng Zhou, Gang Zhu, Fan Chen, Leiyang Li, Wenxing Cui, Fang Sun, Tian Feng, Yue Zhang, Qiang Wang, Shuoyao Ma, Chengxuan Guo, Ziwen Zhang, Kai Wang, Jiahui Wang, Liangbo Wang, Wencong Li, Chenyi Yuan, Haixiao Liu, Liang Wang, Yan Qu   +20 more
wiley   +1 more source