Analysis of CD83 antigen expression in human breast fibroadenoma and adjacent tissue [PDF]
São Paulo Medical Journal, 2011 CONTEXT AND OBJECTIVE: Dendritic cell maturation is considered essential for starting an immune response. The CD83 antigen is an important marker of dendritic cell maturation.
Marcus Nascimento Borges +4 more
doaj +5 more sources
CD83: Activation Marker for Antigen Presenting Cells and Its Therapeutic Potential [PDF]
Frontiers in Immunology, 2019 CD83 is a member of the immunoglobulin (Ig) superfamily and is expressed in membrane bound or soluble forms. Membrane CD83 (mCD83) can be detected on a variety of activated immune cells, although it is most highly and stably expressed by mature dendritic
Ziduo Li +13 more
doaj +3 more sources
Soluble CD83 alleviates experimental allergic rhinitis through modulating antigen-specific Th2 cell property [PDF]
International Journal of Biological Sciences, 2020 Background and aims: Dysfunction of the immune regulatory system plays a role in the pathogenesis of allergic rhinitis (AR). The underlying mechanism needs to be further investigated. Published data indicate that soluble CD83 (sCD83) has immune regulatory activities. This study aims to investigate the role of sCD83 in the alleviation of experimental AR.
Wu, Yong-Jin +8 more
openaire +2 more sources
Human CD83-targeted chimeric antigen receptor T cells prevent and treat graft-versus-host disease [PDF]
Journal of Clinical Investigation, 2020 Graft-versus-host disease (GVHD) remains an important cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (allo-HCT). For decades, GVHD prophylaxis has included calcineurin inhibitors, despite their incomplete efficacy and impairment of graft-versus-leukemia (GVL). Distinct from pharmacologic immune suppression, we have
Bishwas Shrestha +14 more
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Induction of foxp3 during the Crosstalk between Antigen Presenting Like-Cells MHCII+CD83+ and Splenocytes CD4+IgM− in Rainbow Trout [PDF]
Biology, 2021 In fish, the spleen is one of the major immune organs in the animal, and the splenocytes could play a key role in the activation and modulation of the immune response, both innate and adaptive. However, the crosstalk between different types of immune cells in the spleen has been poorly understood.
Morales-Lange, Byron +5 more
openaire +3 more sources
Induction of CD83+CD14+ Nondendritic Antigen-Presenting Cells by Exposure of Monocytes to IFN-α [PDF]
The Journal of Immunology, 2008 Abstract IFN-α is a well-known agent for treatment of viral and malignant diseases. It has several modes of actions, including direct influence on the immune system. We investigated IFN-α effects on PBMC in terms of dendritic cell (DC) differentiation, as PBMC are exposed to high IFN-α levels during treatment of infections and cancers ...
Gianni, Gerlini +11 more
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Antibody to the dendritic cell surface activation antigen CD83 prevents acute graft-versus-host disease [PDF]
Journal of Experimental Medicine, 2009 Allogeneic (allo) hematopoietic stem cell transplantation is an effective therapy for hematological malignancies but it is limited by acute graft-versus-host disease (GVHD). Dendritic cells (DC) play a major role in the allo T cell stimulation causing GVHD.
Wilson, John +9 more
openaire +4 more sources
A-kinase anchoring in dendritic cells is required for antigen presentation. [PDF]
PLoS ONE, 2009 BACKGROUND: Dendritic cells (DC) are the most potent antigen presenting cells (APC) of the immune system. Prostaglandin E(2), cyclic AMP, and protein kinase A (PKA) have all been shown to regulate DC maturation and activity.
Robynn V Schillace +6 more
doaj +1 more source
CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells [PDF]
International Immunology, 2007 CD83 is a member of the Ig superfamily expressed primarily by mature dendritic cells (DCs). In mice, CD83 expression by thymic stromal cells regulates CD4(+) T cell development, with CD83(-/-) mice demonstrating dramatic reductions in both thymus and peripheral CD4(+) T cells. In this study, CD83 expression was also found to affect MHC class II antigen
Yoshihiro, Kuwano +9 more
openaire +2 more sources