Results 51 to 60 of about 124,972 (317)

CD86 Has Sustained Costimulatory Effects on CD8 T Cells [PDF]

The Journal of Immunology, 2007
Abstract CD80 and CD86 both costimulate T cell activation. Their individual effects in vivo are difficult to study as they are coordinately up-regulated on APCs. We have studied mice expressing rat insulin promoter (RIP)-CD80 and RIP-CD86 on the NOD and NOD.scid genetic background to generate in vivo models, using diabetes as a readout ...
Thomas, IJ, Petrich de Marquesini, LG, Ravanan, R, Smith, RM, Guerder, S, Flavell, RA, Wraith, DC, Wen, L, Wong, FS   +8 more
openaire   +2 more sources

Pomalidomide increases immune surface marker expression and immune recognition of oncovirus-infected cells

OncoImmunology, 2019
Most chronic viruses evade T-cell and natural killer (NK) immunity through downregulation of immune surface markers. Previously we showed that Pomalidomide (Pom) increases surface expression of major histocompatibility complex class I (MHC-I) in Kaposi ...
David A. Davis, Prabha Shrestha, Ashley I. Aisabor, Alexandra Stream, Veronica Galli, Cynthia A. Pise-Masison, Takanobu Tagawa, Joseph M. Ziegelbauer, Genoveffa Franchini, Robert Yarchoan   +9 more
doaj   +1 more source

Local Delivery of Ox40l, Cd80, and Cd86 mRNA Kindles Global Anticancer Immunity.

Cancer Research, 2019
Localized expression of effector molecules can initiate antitumor responses through engagement of specific receptors on target cells in the tumor microenvironment.
O. Haabeth, Timothy R. Blake, C. McKinlay, A. Tveita, Adrienne Sallets, R. Waymouth, P. Wender, R. Levy   +7 more
semanticscholar   +1 more source

The Effect of Talaromyces marneffei Infection on CD86 Expression in THP-1 Cells

Infection and Drug Resistance, 2020
Background Talaromyces marneffei (T. marneffei) is a destructive opportunistic dimorphic fungal which can cause lethiferous Talaromycosis, but the clearance of T. marneffei mainly depends on the innate immune response. Objective To investigate whether T.
Di Yang, L. Shen, Rifeng Chen, Yunhua Fu, Hong-Yan Xu, Li-na Zhang, Donghua Liu   +6 more
semanticscholar   +1 more source

CD86 Regulates IgG1 Production via a CD19-Dependent Mechanism [PDF]

The Journal of Immunology, 2007
Abstract CD86 signals directly in a B cell to activate PI3K and increase the rate of IgG1 production, without affecting germline transcription. However, the mechanism by which CD86 activates PI3K in a B cell and the relevance of CD86 stimulation in vivo remains unknown.
Nicholas W, Kin, Virginia M, Sanders
openaire   +2 more sources

The Effect of Talaromyces marneffei Infection on CD86 Expression in THP-1 Cells

Infection and Drug Resistance, 2021
Di Yang,1,* Lin-xia Shen,1,2,* Ri-feng Chen,1,* Yu Fu,1 Hong-yan Xu,1 Li-na Zhang,1 Dong-hua Liu1,3 1Department of Dermatology, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, People’s Republic of China; 2Department of
Yang D, Shen L, Chen R, Fu Y, Xu H, Zhang L, Liu D   +6 more
doaj  

A Potential Inhibitory Profile of Liver CD68+ Cells during HCV Infection as Observed by an Increased CD80 and PD-L1 but Not CD86 Expression. [PDF]

PLoS ONE, 2016
AIM:The lack of potent innate immune responses during HCV infection might lead to a delay in initiating adaptive immune responses. Kupffer cells (KCs) and liver-infiltrating monocytes/macrophages (CD68+ cells) are essential to establish effective anti ...
Elias A Said, Iman Al-Reesi, Marwa Al-Riyami, Khalid Al-Naamani, Shadia Al-Sinawi, Mohammed S Al-Balushi, Crystal Y Koh, Juma Z Al-Busaidi, Mohamed A Idris, Ali A Al-Jabri   +9 more
doaj   +1 more source

Anisakis pegreffii impacts differentiation and function of human dendritic cells [PDF]

, 2018
Human dendritic cells (DCs) show remarkably phenotypic changes when matured in presence of helminth-derived products. These modifications frequently elicited a polarization towards Th2 cells and regulatory T cells thus contributing to immunological ...
Allen, Alonso-Gómez, Annunziato, Aranzamendi, Babal, Baeza, Battisti, Becher, Blanco, Coakley, Cortés, Cvetkovic, D'Amelio, Das Mohapatra, Daschner, Dowling, Entwistle, Gerbe, Giri, Gruden-Movsesijan, Hall, Hartmann, Hiemstra, Iborra, Ivanova, Johnson, Klaver, Kotsias, Kuijk, Lian, Lim, Mattiucci, Mattiucci, Mattiucci, Mattiucci, Mattiucci, Mattiucci, Mattiucci, Mattiucci, Messina, Mladineo, Morris, Motran, Nakahara, Nieuwenhuizen, Pulendran, Rescigno, Rodríguez, Rughetti, Silva, Swofford, Terrazas, Ueno, Umehara, Witkowska, Zizzari   +55 more
core   +1 more source

Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis

bioRxiv, 2019
Background Traditionally, the transcriptomic and proteomic characterisation of CD4 + T cells at the single-cell level has been performed by two largely exclusive types of technologies: single-cell RNA sequencing (scRNA-seq) and antibody-based cytometry ...
D. Trzupek, M. Dunstan, A. Cutler, Mercede Lee, L. Godfrey, L. Jarvis, Daniel B. Rainbow, D. Aschenbrenner, Joanne L. Jones, H. Uhlig, L. Wicker, J. Todd, R. Ferreira   +12 more
semanticscholar   +1 more source

Immunonutrition before esophagectomy: Impact on immune surveillance mechanisms [PDF]

, 2017
Preoperative oral immunonutrition was demonstrated to improve immune response and to decrease the infection rate in patients with cancer. This study aimed to assess how immunonutrition could influence the immune cell response in the mucosal ...
Agostini, Marco, Alfieri, Rita, Cagol, Matteo, Castagliuolo, Ignazio, Castoro, Carlo, Cavallin, Francesco, Fassan, Matteo, Kotsafti, Andromachi, Nardi, Teresa, Pinto, Eleonora, Rugge, Massimo, Scarpa, Marco, Scarpa, Melania   +12 more
core   +1 more source