Results 61 to 70 of about 124,972 (317)

PD-1 or CTLA-4 blockade promotes CD86-driven Treg responses upon radiotherapy of lymphocyte-depleted cancer in mice

Journal of Clinical Investigation
Radiotherapy (RT) is considered immunogenic, but clinical data demonstrating RT-induced T cell priming are scarce. Here, we show in a mouse tumor model representative of human lymphocyte–depleted cancer that RT enhanced spontaneous priming of thymus ...
E. Frijlink, Douwe M. T. Bosma, Julia Busselaar, Thomas W Battaglia, Mo D. Staal, I. Verbrugge, Jannie Borst   +6 more
semanticscholar   +1 more source

KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages [PDF]

, 2016
Among the strategies adopted by glioma to successfully invade the brain parenchyma is turning the infiltrating microglia/macrophages (M/MΦ) into allies, by shifting them toward an anti-inflammatory, pro-tumor phenotype.
Catalano, M, D'Alessandro, G, Di Angelantonio, S, Esposito, V, Esposito, V, Golia, MT, Grimaldi, A, Grössinger, EM, Limatola, C, Ragozzino, D, Santoro, A, Wulff, H   +11 more
core   +2 more sources

Evaluation of the effect of GM-CSF blocking on the phenotype and function of human monocytes [PDF]

, 2020
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multipotent cytokine that prompts the proliferation of bone marrow-derived macrophages and granulocytes.
Esmaeil, Nafiseh, Lotfi, Noushin, Rostami, Mohamad, Zhang, Guang-Xian   +3 more
core   +2 more sources

The potential role of T-cells and their interaction with antigen-presenting cells in mediating immunosuppression following trauma-hemorrhage [PDF]

, 2009
Objective: Trauma-hemorrhage results in depressed immune responses of antigen-presenting cells (APCs) and T-cells. Recent studies suggest a key role of depressed T-cell derived interferon (IFN)-g in this complex immune cell interaction.
Abraham E., Angele MK, Angele MK, Christian P. Schneider, Christian R. Walz, Christiane J. Bruns, de Saint-Vis B., Ertel W., Eugen Faist, Florian Loehe, Irshad H. Chaudry, Landy M., Markus Albertsmeier, Martin K. Angele, Ransom J., Siegfried Zedler   +15 more
core   +1 more source

Expression of CD80 and CD86 costimulatory molecules are potential markers for better survival in nasopharyngeal carcinoma

BMC Cancer, 2007
Background B7 Costimulatory signal is essential to trigger T-cell activation upon the recognition of tumor antigens. This study examined the expression of B7-1 (CD80) and B7-2 (CD86) costimulatory molecules along with HLA-DR and the presence of ...
Lin Hsuan-Yu, Hsu Nicholas C, Chang Julia H, Chang Cheng-Shyong, Chung Chih-Yuan   +4 more
doaj   +1 more source

Time-Dependent Serial Changes of Antigen-Presenting Cell Subsets in the Ocular Surface Are Distinct between Corneal Sterile Inflammation and Allosensitization in a Murine Model

Cells, 2021
The kinetics of antigen-presenting cells (APCs) vary depending on their resident tissues and the manner of immunization. We investigated the long-term changes in mature APC and T-cell subsets over 4 weeks in the ocular surface in murine models of corneal
Kyoung-Woo Kim, Hyun-Ju Lee, Hyeon-Ji Kim, Mee-Kum Kim   +3 more
doaj   +1 more source

Tumor necrosis factor-alpha regulates the expression of inducible costimulator receptor ligand on CD34+ progenitor cells during differentiation into antigen presenting cells [PDF]

, 2001
The inducible costimulator receptor (ICOS) is a third member of the CD28 receptor family that regulates T cell activation and function. ICOS binds to a newly identified ligand on antigen presenting cells different from the CD152 ligands CD80 and CD86. We
Aicher, A, Clark, EA, Daemen, K, Hayden-Ledbetter, M, Irgang, M, Korner, I, Ledbetter, JA, Pezzutto, A, Richter, G, Westermann, J   +9 more
core  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Characterization and profiling of immunomodulatory genes of equine mesenchymal stromal cells from non-invasive sources [PDF]

, 2014
Introduction: Mesenchymal stromal cells (MSCs) have been extensively studied for their promising capabilities in regenerative medicine. Although bone marrow is the best-known source for isolating equine MSCs, non-invasive alternative sources such as ...
De Schauwer, Catharina, Goossens, Karen, Govaere, Jan, Hoogewijs, Maarten, Meyer, Evelyne, Piepers, Sofie, Smits, Katrien, Van de Walle, Gerlinde, Van Soom, Ann   +8 more
core   +2 more sources

Soluble CD86 Is a Costimulatory Molecule for Human T Lymphocytes [PDF]

Immunity, 2000
CD86 is an important costimulatory molecule for the priming and activation of naive and memory T cells, respectively. Here, we show that soluble CD86 is detected in human serum. Soluble CD86 is produced by resting monocytes and results from an alternatively spliced transcript (CD86deltaTM) characterized by deletion of the transmembrane domain ...
Jeannin, Pascale, Magistrelli, Giovanni, Aubry, Jean-Pierre, Caron, Gersende, Gauchat, Jean-François, Renno, Toufic, Herbault, Nathalie, Goetsch, Liliane, Blaecke, Aline, Dietrich, Pierre-Yves, Bonnefoy, Jean-Yves, Delneste, Yves   +11 more
openaire   +3 more sources