Results 61 to 70 of about 6,241 (179)
JCI Insight, 2022 We investigate how myeloid subsets differentially shape immunity to pancreatic ductal adenocarcinoma (PDA). We show that tumor antigenicity sculpts myeloid cell composition and functionality.
Adam L. Burrack +10 more
doaj +1 more source
Nature Communications, 2021 Acquisition of dying tumor cell-associated antigens is an essential step for the initiation of anti-tumor immune response by conventional type 1 dendritic cells (cDC1).
Nicoletta Caronni +21 more
doaj +1 more source
GM-CSF, Flt3-L and IL-4 affect viability and function of conventional dendritic cell types 1 and 2
Frontiers in Immunology, 2023 Conventional type 1 dendritic cells (cDC1) and conventional type 2 dendritic cells (cDC2) have attracted increasing attention as alternatives to monocyte-derived dendritic cells (moDCs) in cancer immunotherapy.
Seyed Mohammad Lellahi +14 more
doaj +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi +6 more
wiley +1 more source
Negligible Role for Deletion Mediated by cDC1 in CD8+ T Cell Tolerance [PDF]
The Journal of Immunology, 2019 Abstract Deletion of CD8+ T cells by dendritic cells (DCs) is recognized as a critical mechanism of immune tolerance to self-antigens. Although DC-mediated peripheral deletion of autoreactive CD8+ T cells has been demonstrated using T cells reactive to model Ags, its role in shaping the naturally occurring polyclonal CD8+ T cell ...
Brendan W MacNabb +6 more
openaire +2 more sources
Single Cell Analysis Reveals Dynamic Changes of Distinct Cell Populations in Human Nickel Allergy
Allergy, EarlyView.We investigated cell types mediating the early and late inflammatory responses in human Ni2+‐allergy by scRNA‐Seq. Early responsiveness was mainly mediated by TLR4+TAGLN− endothelial cells indirectly activating TLR4−KRT16+ keratinocytes, and CCR7+DCN+ DCs. Late responsiveness was crucially driven by infiltration of KLF2+ central memory T cells and TLR4+
Marc Schmidt +7 more
wiley +1 more source
Signal Transduction and Targeted TherapyConventional type 1 dendritic cells (cDC1) are the essential antigen-presenting DC subset in antitumor immunity. Suppressing B-cell lymphoma 9 and B-cell lymphoma 9-like (BCL9/BCL9L) inhibits tumor growth and boosts immune responses against cancer ...
Fenglian He +9 more
doaj +1 more source
The Therapeutic Potential of Farm Dust Extracts in a Mouse Model of Eosinophilic Inflammation
Allergy, EarlyView.Farm dust extract (FDE) treatment reduces airway eosinophilia, mucus overproduction, and MHC‐II expression on DCs, limiting antigen presentation and Th2 inflammation. It increases PD‐L1 on DCs, promoting T cell deactivation. Additionally, FDE enhances Tregs and upregulates CTLA‐4, reinforcing suppression.
Rabia Ülkü Korkmaz +16 more
wiley +1 more source
ILC1-derived IFN-γ mediates cDC1-dependent host resistance againstToxoplasma gondii [PDF]
, 2020 ABSTRACTHost resistance against intracellular pathogens requires a rapid IFN-γ mediated immune response. We reveal that T-bet-dependent production of IFN-γ is essential for the maintenance of inflammatory DCs at the site of infection with a common protozoan parasite,Toxoplasma gondii.
López-Yglesias, Américo H. +6 more
openaire +1 more source
Frontiers in Immunology, 2018 Porcine Reproductive and Respiratory Syndrome virus (PRRSV) is an arterivirus responsible for highly contagious infection and huge economic losses in pig industry. Two species, PRRSV-1 and PRRSV-2 are distinguished, PRRSV-1 being more prevalent in Europe.
Elise Bordet +17 more
doaj +1 more source