Results 81 to 90 of about 6,241 (179)

Type I-conventional dendritic cells support the progression of multiple myeloma in the bone marrow

Frontiers in Immunology
PurposeType I conventional dendritic cells (cDC1s) play a key role in priming anti-tumor cytotoxic T cells and inducing immune tolerance for self-antigens and tumor antigens. However, it remains unclear whether cDC1 has a protective or pathogenic role in
Sayaka Suzuki, Sayaka Suzuki, Kazuma Komiya, Shogo Tsuda, Miya Yoshino, Tsuneyasu Kaisho, P. Leif Bergsagel, Koji Kawamura, Tetsuya Fukuda, Tetsuya Fukuda, Koji Tokoyoda   +10 more
doaj   +1 more source

Histiocytes: Multifaceted Regulators of Health and Disease

Veterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source

Vaccination against neoantigens induced in cross-priming cDC1 in vivo

Cancer Immunology, Immunotherapy
AbstractThe conventional type 1 dendritic cells (cDC1) play a pivotal role in protective immunity against pathogens and cancer. However, their low frequency in the blood and tissues limits their use in immune therapy. We have recently described a method to vaccinate against neoantigens that are induced in tumor cells by targeted delivery of a TAP siRNA
Emily S. Clark, Ana Paula Benaduce, Wasif N. Khan, Olivier Martinez, Eli Gilboa   +4 more
openaire   +2 more sources

γδ T cell-mediated activation of cDC1 orchestrates CD4+ Th1 cell priming in malaria

Frontiers in Immunology
γδ T cells facilitate the CD4+ T helper 1 (Th1) cell response against Plasmodium infection by activating conventional dendritic cells (cDCs), although the underlying mechanism remains elusive.
Yarob Ibraheem, Ganchimeg Bayarsaikhan, Maria Lourdes Macalinao, Kazumi Kimura, Katsuyuki Yui, Katsuyuki Yui, Katsuyuki Yui, Taiki Aoshi, Shin-Ichi Inoue   +8 more
doaj   +1 more source

Dendritic Cell‐T Cell Crosstalk Mediated Cancer Immunotherapy

Exploration, EarlyView.
Ying Cai, Jiameng Chen, Yaping Li
wiley   +1 more source

Social transformation through community music projects: A scoping review

Review of Education, Volume 14, Issue 1, April 2026.
Abstract This article investigates the hypothesis that music can be a powerful catalyst for social transformation within specific territorial and social contexts. To explore this, a scoping review was conducted, aiming to identify the participants, networks and contexts described in the scientific literature on community music and to critically examine
Noemy Berbel‐Gómez, Lluís Ballester‐Brage, Laura Serra‐Marín, Júlia Mérida‐Coli   +3 more
wiley   +1 more source

MyD88 Deficiency Protects Mice From Experimental Autoimmune Encephalomyelitis by Influencing Both Dendritic Cells and T Cells

Immunology, Volume 177, Issue 4, Page 784-797, April 2026.
This study investigates the role of MyD88 in dendritic cells (DCs) and T cells during experimental autoimmune encephalomyelitis (EAE). We found that MyD88 is highly expressed in DCs and CD4+ T cells in people with multiple sclerosis, and its deficiency impairs DC maturation, reduces pro‐inflammatory cytokine production, weakens DC–T cell interactions ...
Wen Si, Gaochen Zhu, Qianling Jiang, Xin Ma, Guan Yang   +4 more
wiley   +1 more source

Importance of EMT Factor ZEB1 in cDC1 “MutuDC Line” Mediated Induction of Th1 Immune Response

Frontiers in Immunology, 2018
The role of Epithelial to Mesenchymal Transition (EMT) factor Zeb1 is well defined in metastasis and cancer progression but it's importance in dendritic cells (DCs) is unexplored until now. For the first time we report here that Zeb1 controls immunogenic
Shuchi Smita, Shuchi Smita, Abdul Ahad, Abdul Ahad, Arup Ghosh, Arup Ghosh, Viplov K. Biswas, Viplov K. Biswas, Marianna M. Koga, Bhawna Gupta, Hans Acha-Orbea, Sunil K. Raghav, Sunil K. Raghav, Sunil K. Raghav   +13 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, Volume 20, Issue 3, Page 753-778, March 2026.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Dendritic cell-targeted therapy expands CD8 T cell responses to bona-fide neoantigens in lung tumors

Nature Communications
Cross-presentation by type 1 DCs (cDC1) is critical to induce and sustain antitumoral CD8 T cell responses to model antigens, in various tumor settings.
Lucía López, Luciano Gastón Morosi, Federica La Terza, Pierre Bourdely, Giuseppe Rospo, Roberto Amadio, Giulia Maria Piperno, Valentina Russo, Camilla Volponi, Simone Vodret, Sonal Joshi, Francesca Giannese, Dejan Lazarevic, Giovanni Germano, Patrizia Stoitzner, Alberto Bardelli, Marc Dalod, Luigia Pace, Nicoletta Caronni, Pierre Guermonprez, Federica Benvenuti   +20 more
doaj   +1 more source