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Targeting CDK1 in cancer: mechanisms and implications
npj Precision Oncology, 2023 Cyclin dependent kinases (CDKs) are serine/threonine kinases that are proposed as promising candidate targets for cancer treatment. These proteins complexed with cyclins play a critical role in cell cycle progression.
Qiushi Wang, Ann M. Bode, Tianshun Zhang
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Targeting cyclin-dependent kinase 1 (CDK1) in cancer: molecular docking and dynamic simulations of potential CDK1 inhibitors [PDF]
Medical Oncology, 2022 Cell cycle dysregulation is a characteristic hallmark of malignancies, which results in uncontrolled cell proliferation and eventual tumor formation. Cyclin-dependent kinase 1 (CDK1) is a member of the family of cell cycle regulatory proteins involved in
Shazia Sofi +6 more
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Cell & Bioscience, 2023 Background Pancreatic cancer stem cells (CSCs) promote pancreatic ductal adenocarcinoma (PDAC) tumorigenesis and chemoresistance. Cyclin-dependent kinase 1 (CDK1) plays an important role in tumor initiation in other tumors, but the function of CDK1 in ...
Xiaodong Xu +9 more
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PKM2 Interacts With the Cdk1-CyclinB Complex to Facilitate Cell Cycle Progression in Gliomas
Frontiers in Oncology, 2022 PKM2 is a phosphotyrosine-binding glycolytic enzyme upregulated in many cancers, including glioma, and contributes to tumor growth by regulating cell cycle progression. We noted, however, that in multiple glioma cell lines, PKM2 knock-down resulted in an
Shigeo Ohba +6 more
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Advanced Science, 2023 Oxaliplatin is a widely used chemotherapy drug for patients with advanced colorectal cancer (CRC); however, frequent drug resistance limits its therapeutic efficacy in patients.
Kaixuan Zeng +7 more
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USP14 regulates cell cycle progression through deubiquitinating CDK1 in breast cancer
Acta Biochimica et Biophysica Sinica, 2022 Abnormal proliferation and cell cycle perturbation are the main hallmarks of breast cancer. Cyclin-dependent kinase 1 (CDK1) is one of the key kinases for cell transition from the G2 phase to M phase during the cell cycle progression.
Liu Yuhan +6 more
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CDK1 serves as a potential prognostic biomarker and target for lung cancer
Journal of International Medical Research, 2020 Objective Evidence from cell and mouse models and human tissues suggests that cyclin dependent kinase 1 (CDK1) is involved in lung cancer (LC) tumorigenesis.
Mingyao Li +4 more
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Cancer Management and Research, 2020 Suying Lu,1,2,* Chengtao Sun,3,* Huimou Chen,1,2,* Chao Zhang,1,4,* Wei Li,5 Liuhong Wu,1,2 Jia Zhu,1,2 Feifei Sun,1,2 Junting Huang,1,2 Juan Wang,1,2 Zijun Zhen,1,2 Ruiqing Cai,1,2 Xiaofei Sun,1,2 Yizhuo Zhang,1,2 Xing Zhang1,6 1State Key Laboratory of ...
Lu S +14 more
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CDK1 may promote breast cancer progression through AKT activation and immune modulation [PDF]
Frontiers in OncologyBackgroundCyclin-dependent kinase 1 (CDK1) plays a crucial role in regulating the cell cycle, yet its clinical relevance and molecular mechanisms in breast cancer remain insufficiently characterized.
Huanhong Zeng +7 more
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Cyclin B1/CDK1-regulated mitochondrial bioenergetics in cell cycle progression and tumor resistance. [PDF]
Cancer Letters, 2019 A mammalian cell houses two genomes located separately in the nucleus and mitochondria. During evolution, communications and adaptations between these two genomes occur extensively to achieve and sustain homeostasis for cellular functions and ...
Jiang, Nian +3 more
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