Results 151 to 160 of about 72,520 (322)

Caldesmon regulates actin dynamics to influence cranial neural crest migration in Xenopus [PDF]

, 2011
Caldesmon (CaD) is an important actin modulator that associates with actin filaments to regulate cell morphology and motility. Although extensively studied in cultured cells, there is little functional information regarding the role of CaD in migrating ...
Bronner-Fraser, Marianne, Kee, Yun, Nie, Shuyi   +2 more
core   +2 more sources

Halorotetin B, A Novel Terpenoid Compound Derived from Marine Ascidian, Suppresses Tumor Growth by Targeting the Cell Cycle Regulator UBE2C

Advanced Science, EarlyView.
Halorotetin B, a novel small‐molecule terpenoid identified from an edible marine ascidian, exhibits strong anti‐tumor activity both in vitro and in vivo through direct targeting UBE2C to induce tumor cell cycle arrest and then lead tumor cell senescence. As a newly discovered UBE2C inhibitor, Halorotetin B can serve as a novel potential cell senescence
Shanhao Han, Jianhui Li, Yuting Zhu, Penghui Liu, Yaoyao Zheng, Muchun He, Bo Dong   +6 more
wiley   +1 more source

Preparation for mitosis requires gradual CDK1 activation

iScience
G2 phase is considered as a time in which cells prepare for the large structural changes in the following mitosis. Starting at completion of DNA replication, CDK1 and PLK1 kinase activities gradually increase throughout G2 phase until reaching levels that initiate mitosis.
Karen Akopyan, Zhiyu Hao, Arne Lindqvist
openaire   +4 more sources

CDK1 makes the meiotic spindle wait [PDF]

Journal of Cell Biology, 2013
![Figure][1] In an oocyte with enhanced CDK1 activity, every kinetochore (red) forms a stable, end-on attachment to a spindle microtubule (green). A delay in cyclin-dependent kinase activity prevents meiotic chromosomes from prematurely attaching to spindle microtubules, [Davydenko et ...
openaire   +1 more source

CHK1‐CDC25A‐CDK1 regulate cell cycle progression and protect genome integrity in early mouse embryos [PDF]

, 2023
Lucie Knoblochová, Tomáš Ďuríček, Michaela Vaškovičová, Chrysoula Zorzompokou, Diana Rayova, Ivana Ferencova, Vladimı́r Baran, Richard M. Schultz, Eva R. Hoffmann, Dávid Drutovič   +9 more
openalex   +1 more source

Cycling in synchrony [PDF]

, 2019
The corn smut fungus uses two different mechanisms to control its cell cycle when it is infecting ...
Bardetti, Chang, Fukada, Li, Müller, Nurse, Osés-Ruiz, Savary, Urban   +8 more
core   +1 more source

TOPK Inhibition Promotes Anti‐Tumor Immunity Via eIF4F Complex Mediated STAT1 Translation in Gastric Cancer

Advanced Science, EarlyView.
This study identifies TOPK as a dual‐function target in gastric cancer: it drives tumor cell proliferation and migration, and under IFN‐γ stimulation, phosphorylates eIF4F complex component eIF4A1 to enhance STAT1 mRNA translation, thereby promoting PD‐L1/IDO1‐mediated tumor immunometabolic evasion.
Junbing Chen, Longtao Huangfu, Gangjian Wang, Xueying Wang, Huanbo Zhu, Qian Yao, Cong Chen, Xiaohuan Tang, Ting Guo, Biao Fan, Xingyang Liu, Qingda Li, Zining Liu, Ying Hu, Tianze Sun, Jiafu Ji, Xiaofang Xing   +16 more
wiley   +1 more source

KA1-targeted regulatory domain mutations activate Chk1 in the absence of DNA damage [PDF]

, 2015
The Chk1 protein kinase is activated in response to DNA damage through ATR-mediated phosphorylation at multiple serine-glutamine (SQ) residues within the C-terminal regulatory domain, however the molecular mechanism is not understood. Modelling indicates
Freire, Raimundo, Fumagallo, Felipe, Gillespie, David A., Gong, Eun Yeung, Morrice, Nicholas, Piscitello, Desiree, Smits, Veronique A.J.   +6 more
core   +1 more source

A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Advanced Science, EarlyView.
Contextual fear conditioning induces BNIP3L‐dependent mitochondrial fission in glutamatergic neurons of the BLA, independently of mitophagy. Loss of BNIP3L elevates Drp1Ser637 phosphorylation, thereby suppressing mitochondrial fission, compromising ATP production, and attenuating excitatory synaptic transmission.
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen, Xiangnan Zhang   +13 more
wiley   +1 more source

Fcp1 phosphatase controls Greatwall kinase to promote PP2A-B55 activation and mitotic progression

eLife, 2015
During cell division, progression through mitosis is driven by a protein phosphorylation wave. This wave namely depends on an activation-inactivation cycle of cyclin B-dependent kinase (Cdk) 1 while activities of major protein phosphatases, like PP1 and ...
Rosa Della Monica, Roberta Visconti, Nando Cervone, Angela Flavia Serpico, Domenico Grieco   +4 more
doaj   +1 more source