Results 181 to 190 of about 67,859 (329)

Selective modulation of the cyclin B/CDK1 and cyclin D/CDK4 complexes during in vitro human megakaryocyte development [PDF]

, 1999
Alessandra Bassini, Sabina Pierpaoli, Elisabetta Falcieri, Marco Vitale, Lia Guidotti, Silvano Capitani, Giorgio Zauli   +6 more
openalex   +1 more source

Structural basis of human separase regulation by securin and CDK1–cyclin B1

Nature, 2021
Jun Yu, P. Raia, C. M. Ghent, T. Raisch, Y. Sadian, S. Cavadini, Pramod M. Sabale, D. Barford, S. Raunser, D. Morgan, A. Boland   +10 more
semanticscholar   +1 more source

HN1 Functions in Protein Synthesis Regulation via mTOR‐RPS6 Axis and Maintains Nucleolar Integrity

Cell Proliferation, EarlyView.
HN1 is required for nucleolar homeostasis which is the site of ribosome biogenesis and protein synthesis when its mRNA is knocked down by shRNA, it depletes in cytoplasm and the protein synthesis is downregulated in comparison to controls. Thus, the proliferating cells requiring vast number of nucleosomes, are arrested at S onset.
Gülseren Özduman, Aadil Javed, Azime Akçaöz Alasar, Bünyamin Akgül, Kemal Sami Korkmaz   +4 more
wiley   +1 more source

WEE1 kinase inhibitor AZD1775 induces CDK1 kinase-dependent origin firing in unperturbed G1- and S-phase cells

Proceedings of the National Academy of Sciences of the United States of America, 2019
WEE1 kinase is a key regulator of the G2/M transition. The WEE1 kinase inhibitor AZD1775 (WEE1i) induces origin firing in replicating cells. We show that WEE1i induces CDK1-dependent RIF1 phosphorylation and CDK2- and CDC7-dependent activation of the ...
T. Moiseeva, Chenao Qian, Norie Sugitani, H. Osmanbeyoglu, C. Bakkenist   +4 more
semanticscholar   +1 more source

The S‐Phase Arrest of Host Cells Caused by an Alpha‐Herpesvirus Genome Replication Facilitates Viral Recruitment of RNA Polymerase II to Transcribe Viral Genes

Cell Proliferation, EarlyView.
Viral infection arrests host cells in the S phase, which promotes vDNA synthesis and vRC formation, further facilitating viral recruitment of RNA Pol II to preferentially transcribe viral genes. ABSTRACT Herpesviruses rely on host RNA polymerae II (RNA Pol II) for their mRNA transcription, yet the mechanisms of which has been poorly defined, while ...
Qiqi Yang, Ying Wu, Mingshu Wang, Shun Chen, Renyong Jia, Qiao Yang, Dekang Zhu, Mafeng Liu, Xinxin Zhao, Shaqiu Zhang, Juan Huang, Xumin Ou, Di Sun, Bin Tian, Yu He, Zhen Wu, Anchun Cheng   +16 more
wiley   +1 more source

Cdk1: A kinase with changing substrate specificity [PDF]

Cell Cycle, 2011
Mardo Kõivomägi, Mart Loog
openaire   +3 more sources

Hamartin and Tuberin Interaction With the G2/M Cyclin-Dependent Kinase CDK1 and Its Regulatory Cyclins A and B [PDF]

, 2001
Michael Catania, Paul S. Mischel, Harry V. Vinters   +2 more
openalex   +1 more source

COPS2 Antagonizes OCT4 to Accelerate the G2/M Transition of Mouse Embryonic Stem Cells

Stem Cell Reports, 2018
Summary: Proper regulation of the cell cycle is essential to safeguard the genomic integrity of embryonic stem cells (ESCs) while maintaining the fast proliferation rate.
Peng Li, Nan Ding, Weiyu Zhang, Lingyi Chen   +3 more
doaj  

Super‐Enhancer Target Gene CBP/p300‐Interacting Transactivator With Glu/Asp‐Rich C‐Terminal Domain, 2 Cooperates With Transcription Factor Forkhead Box J3 to Inhibit Pulmonary Vascular Remodeling

Cell Proliferation, EarlyView.
During hypoxia, the transcriptional effect of super‐enhancer in promoting CBP/p300‐interacting transactivator with Glu/Asp‐rich C‐terminal domain, 2 reduced, eventually leading to the thickening of the smooth muscle layer of the pulmonary artery.
Songyue Li, Jingya Zhang, Xu Wang, Xinru Wang, Yuyu Song, Xinyue Song, Xiuli Wang, Weiwei Cao, Chong Zhao, Jing Qi, Xiaodong Zheng, Yan Xing   +11 more
wiley   +1 more source

Evidence for regulation of protein synthesis at the elongation step by CDK1/cyclin B phosphorylation [PDF]

, 2001
Annabelle Monnier
openalex   +1 more source