Results 11 to 20 of about 67,859 (329)
Targeting CDK1 in cancer: mechanisms and implications
npj Precision Oncology, 2023 Cyclin dependent kinases (CDKs) are serine/threonine kinases that are proposed as promising candidate targets for cancer treatment. These proteins complexed with cyclins play a critical role in cell cycle progression.
Qiushi Wang, Ann M. Bode, Tianshun Zhang
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Medical Oncology, 2022 Cell cycle dysregulation is a characteristic hallmark of malignancies, which results in uncontrolled cell proliferation and eventual tumor formation. Cyclin-dependent kinase 1 (CDK1) is a member of the family of cell cycle regulatory proteins involved in cell cycle maintenance.
Shazia Sofi +6 more
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USP14 regulates cell cycle progression through deubiquitinating CDK1 in breast cancer
Acta Biochimica et Biophysica Sinica, 2022 Abnormal proliferation and cell cycle perturbation are the main hallmarks of breast cancer. Cyclin-dependent kinase 1 (CDK1) is one of the key kinases for cell transition from the G2 phase to M phase during the cell cycle progression.
Liu Yuhan +6 more
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Advanced Science, 2023 Oxaliplatin is a widely used chemotherapy drug for patients with advanced colorectal cancer (CRC); however, frequent drug resistance limits its therapeutic efficacy in patients.
Kaixuan Zeng +7 more
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CDK1 serves as a potential prognostic biomarker and target for lung cancer
Journal of International Medical Research, 2020 Objective Evidence from cell and mouse models and human tissues suggests that cyclin dependent kinase 1 (CDK1) is involved in lung cancer (LC) tumorigenesis.
Mingyao Li +4 more
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CDK1 is up-regulated by temozolomide in an NF-κB dependent manner in glioblastoma
Scientific Reports, 2021 The alkylating agent, temozolomide (TMZ), is the most commonly used chemotherapeutic for the treatment of glioblastoma (GBM). The anti-glioma effect of TMZ involves a complex response that includes G2-M cell cycle arrest and cyclin-dependent kinase 1 ...
David J. Voce +9 more
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CDK1 couples proliferation with protein synthesis
Journal of Cell Biology, 2019 Cell proliferation exerts a high demand on protein synthesis, yet the mechanisms coupling the two processes are not fully understood. A kinase and phosphatase screen for activators of translation, based on the formation of stress granules in human cells, revealed cell cycle–associated kinases as major candidates.
Christian Kroun Damgaard +10 more
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Biomolecules, 2021 DNMT3A mutations are frequently identified in acute myeloid leukemia (AML) and indicate poor prognosis. Previously, we found that the hotspot mutation DNMT3A R882H could upregulate CDK1 and induce AML in conditional knock-in mice.
Ying Yang +4 more
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Copper is essential for cyclin B1-mediated CDK1 activation [PDF]
Nature CommunicationsCyclin-dependent kinase 1 (CDK1) is the pivotal kinase responsible for initiating cell division. Its activation is dependent on binding to regulatory cyclins, such as CCNB1.
Jiaru Wang +12 more
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Cyclin B1/CDK1-regulated mitochondrial bioenergetics in cell cycle progression and tumor resistance. [PDF]
Cancer Letters, 2019 A mammalian cell houses two genomes located separately in the nucleus and mitochondria. During evolution, communications and adaptations between these two genomes occur extensively to achieve and sustain homeostasis for cellular functions and ...
Jiang, Nian +3 more
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