Results 11 to 20 of about 72,520 (322)
Compartmentalized control of Cdk1 drives mitotic spindle assembly [PDF]
Cell Reports, 2022 Summary: During cell division, dramatic microtubular rearrangements driven by cyclin B-cdk1 (Cdk1) kinase activity mark the onset of mitosis leading to dismantling of the interphase microtubular cytoskeleton and assembly of the mitotic spindle.
Angela Flavia Serpico +3 more
doaj +5 more sources
Biomolecules, 2021 DNMT3A mutations are frequently identified in acute myeloid leukemia (AML) and indicate poor prognosis. Previously, we found that the hotspot mutation DNMT3A R882H could upregulate CDK1 and induce AML in conditional knock-in mice.
Ying Yang +4 more
doaj +2 more sources
CDK1 drives SOX9-mediated chemotherapeutic resistance in gastric cancer [PDF]
Journal of Experimental & Clinical Cancer ResearchBackground Gastric carcinoma ranks as the fifth most common cause of cancer-related mortality globally. Chemoresistance remains a critical barrier to treatment efficacy, driving poor survival outcomes in gastric cancer patients. Cyclin-dependent kinase 1
Marwah Al-Mathkour +14 more
doaj +2 more sources
CDK1 couples proliferation with protein synthesis
Journal of Cell Biology, 2019 Cell proliferation exerts a high demand on protein synthesis, yet the mechanisms coupling the two processes are not fully understood. A kinase and phosphatase screen for activators of translation, based on the formation of stress granules in human cells,
Katharina Haneke +9 more
semanticscholar +4 more sources
Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. [PDF]
, 2010 The pro-apoptotic function of p53 has been well defined in preventing genomic instability and cell transformation. However, the intriguing fact that p53 contributes to a pro-survival advantage of tumor cells under DNA damage conditions raises a critical ...
Duru, Nadire +5 more
core +23 more sources
Suppressing CDCA8/CDK1 improves oral squamous cell carcinoma by modulating proliferation, apoptosis, cell cycle and migration [PDF]
Discover OncologyWe aimed to clarify the role of CDCA8/CDK1 in the progression of oral squamous cell carcinoma (OSCC) and the potential mechanisms. To explore the CDCA8 expression in OSCC, clinical samples were collected.
Jiang Zhu +6 more
doaj +2 more sources
Journal of Experimental and Molecular Biology, 2023 Osteosarcoma (OS), a malignancy primarily affecting children and adolescents, is the most frequently encountered malignant, non-hematologic, bone tumor.
Alexandru Bogdan Stache +7 more
doaj +1 more source
The effect of vitrification after warming on the expressions of p38, CDK1, and cyclin B in immature goat oocytes followed by in vitro maturation [PDF]
Veterinary World, 2020 Background and Aim: The combination of vitrification techniques and in vitro maturation can reduce oocyte competence. Mitogen-activated protein kinase and maturation-promoting factor are significant in oocyte meiotic maturation regulation.
A. A. Muhammad Nur Kasman +2 more
doaj +1 more source
Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions
Advancement of science, 2023 Triple‐negative breast cancer (TNBC) is a highly lethal malignancy with limited therapy options. TWIST1, a key transcriptional factor of epithelial‐mesenchymal transition (EMT), contributes to self‐renewal of cancer stem‐like cells (CSCs), chemo ...
Tangming Guan +14 more
semanticscholar +1 more source
Journal of Translational Medicine, 2022 Background Adrenocortical carcinoma (ACC) is an extremely rare, aggressive tumor with few effective therapeutic options or drugs. Mitotane (Mtn), which is the only authorized therapeutic drug, came out in 1970 and is still the only first-line treatment ...
Li-wen Ren +13 more
semanticscholar +1 more source