Results 201 to 210 of about 69,053 (332)

Differential gene expression in Chorthippus parallelus (Zetterstedt, 1821) (Orthoptera: Acrididae: Gomphocerinae) induced by Wolbachia infection

Insect Science, EarlyView.
Distinct lineages of the grasshopper Chorthippus parallelus (Orthoptera: Acrididae) form a well‐known hybrid zone (HZ) in the Pyrenees mountain range; the Iberian endemism C. p. erythropus (Cpe) and the subspecies C. p. parallelus, (Cpp) widely distributed throughout the rest of Europe. Both subspecies differ in diverse traits, including the strains of
Patricia Jiménez‐Florido, Mónica Aquilino, David Buckley, José L. Bella, Rosario Planelló   +4 more
wiley   +1 more source

p21-Mediated Nuclear Retention of Cyclin B1-Cdk1 in Response to Genotoxic Stress [PDF]

, 2004
Fabienne Charrier‐Savournin, Marie‐Thérèse Château, Véronique Gire, John M. Sedivy, Jacques Piette, Vjekoslav Dulić   +5 more
openalex   +1 more source

Nuclear Import Defects Drive Cell Cycle Dysregulation in Neurodegeneration

Aging Cell, EarlyView.
Overview of Dysregulated Cell Cycle Mechanisms in Neuronal Cells. A nuclear import block drives cell cycle re‐entry from G0, culminating in cell cycle arrest at G1/S. This cell cycle arrest is associated with activation of CKIs from the INK locus (p15, p16, p18, p19) and Cip/Kip (p21, p27) which act on specific CDK/Cyclin complexes.
Jonathan Plessis‐Belair, Taylor Russo, Markus Riessland, Roger B. Sher   +3 more
wiley   +1 more source

Fbx7 Functions in the SCF Complex Regulating Cdk1-Cyclin B-phosphorylated Hepatoma Up-regulated Protein (HURP) Proteolysis by a Proline-rich Region [PDF]

, 2004
Jung-Mao Hsu, Yuan-Chii G. Lee, Chang‐Tze Ricky Yu, Chi‐Ying F. Huang   +3 more
openalex   +1 more source

Synergistic potential of CDK4/6 inhibitors and ATRA in non‐APL AML

British Journal of Haematology, EarlyView.
Summary Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by diverse genetic abnormalities. The standard of care remains to be chemotherapy and stem cell transplantation. In acute promyelocytic leukaemia (APL), differentiation therapy with all‐trans retinoic acid (ATRA) has significantly improved outcomes. Despite this, the success
Rafał Skopek, Setenay Gupse Özcan, Paulina Chmiel, Stephanie Morgner, Jaqueline Schütt, Faezeh Ghazvini Zadegan, Clara Stanko, Małgorzata Palusińska, Karolina Maślińska‐Gromadka, Yordan Sbirkov, Sven Stengel, Martin Fischer, Annamaria Brioli, Arthur Zelent, Łukasz Szymański, Tino Schenk   +15 more
wiley   +1 more source

Unraveling the interplay between PKA inhibition and Cdk1 activation during oocyte meiotic maturation

Cell Reports
Summary: Oocytes are arrested in prophase I. In vertebrates, meiotic resumption is triggered by hormonal stimulation that results in cAMP-dependent protein kinase (PKA) downregulation leading to Cdk1 activation.
Martina Santoni, Ferdinand Meneau, Nabil Sekhsoukh, Sandrine Castella, Tran Le, Marika Miot, Enrico Maria Daldello   +6 more
doaj  

Cyclin A/Cdk2 complexes regulate activation of Cdk1 and Cdc25 phosphatases in human cells [PDF]

, 2004
Jayashree Mitra, Greg H. Enders
openalex   +1 more source

NFATc4 Promotes Lung Adenocarcinoma Progression via the CCNB1/CDK1 Pathway and Is a Potential Prognostic Biomarker

Cancer Science, EarlyView.
NFATc4 is upregulated in LUAD, and its high expression correlates with the malignant progression of patients. NFATc4 enhances LUAD cell viability and proliferation by regulating the G2/M phase transition and apoptosis. Functionally, NFATc4 directly binds to the CCNB1 promoter, modulating the CCNB1/CDK1 pathway, which results in cell cycle arrest and ...
Wendi Yang, Xue Wu, Fanghao Cai, Zhengjun Guo, Zaicheng Xu, Yuan Peng, Zhenzhou Yang, Xiaoyue Zhang   +7 more
wiley   +1 more source

Cdc28/Cdk1 Regulates Spindle Pole Body Duplication through Phosphorylation of Spc42 and Mps1 [PDF]

, 2004
Sue L. Jaspersen, Brenda J. Huneycutt, Thomas H. Giddings, Katheryn A. Resing, Natalie G. Ahn, Mark Winey   +5 more
openalex   +1 more source

PBK Expression Promotes the Aggressive Phenotypes of Mesothelioma

Cancer Science, EarlyView.
PBK plays a crucial role in cell survival in mesothelioma and is associated with worse outcome. PBK is a promising therapeutic target that may serve as a prognostic biomarker, enabling personalized treatment of mesothelioma. ABSTRACT Mesothelioma is one of the most aggressive neoplasms worldwide that has a particularly poor prognosis.
Kazumi Hori, Ichidai Tanaka, Tatsuhiro Sato, Mika Sato, Yuta Kodama, Hideyuki Itoigawa, Yuichi Abe, Taketo Kato, Ayumu Taguchi, Mitsuo Sato, Yoshitaka Sekido, Toyofumi Fengshi Chen‐Yoshikawa, Makoto Ishii   +12 more
wiley   +1 more source