Results 211 to 220 of about 69,053 (332)

Repression of CDK1 and Other Genes with CDE and CHR Promoter Elements during DNA Damage-Induced G₂/M Arrest in Human Cells

, 2000
Christophe Badie, Jane E. Itzhaki, Matthew J. Sullivan, Adam J. Carpenter, Andrew C.G. Porter   +4 more
openalex   +2 more sources

Regulation of Activation-induced Fas (CD95/Apo-1) Ligand Expression in T Cells by the Cyclin B1/Cdk1 Complex [PDF]

, 2004
Ralph Torgler, Sabine Jakob, Edgar Ontsouka, Ueli Nachbur, Christoph Mueller, Douglas R. Green, Thomas Brunner   +6 more
openalex   +1 more source

HROB Induces Lung Adenocarcinoma Progression via ZC3HC1‐CCNB1 Axis Regulation and Cell Cycle Dysregulation

Cancer Science, EarlyView.
We have uncovered a novel mechanism by which HROB modulates cell proliferation in lung adenocarcinoma. Our findings suggest that HROB recruits ZC3HC1 and mediates its de‐phosphorylation at Ser354, which in turn promotes K27‐linked ubiquitination of CCNB1, leading to its proteasomal degradation.
Zhe Zhang, Cheng Wang, Yuanwei Guo, Zhenyu Zhao, Zhi Yang, Shouzhi Xie, Xinhang Hu, Xingchun Huang, Yupeng Jiang, Bing Xiao, Li Wang, Fenglei Yu, Bin Wang   +12 more
wiley   +1 more source

Recombinant cyclin B-Cdk1-Suc1 capable of multi-site mitotic phosphorylation in vitro.

PLoS ONE
Cyclin-dependent kinase 1 (Cdk1) complexed with cyclin B phosphorylates multiple sites on hundreds of proteins during mitosis. However, it is not fully understood how multi-site mitotic phosphorylation by cyclin B-Cdk1 controls the structures and ...
Keishi Shintomi, Yuki Masahara-Negishi, Masami Shima, Shoji Tane, Tatsuya Hirano   +4 more
doaj   +1 more source

Control of DNA Synthesis and Mitosis by the Skp2-p27-Cdk1/2 Axis [PDF]

, 2004
Michele Pagano
openalex   +1 more source

TP‐0903 Suppresses Aurora A–PLK1 Signaling to Inhibit Proliferation of a Myelodysplastic Syndrome‐Derived Cell Line

Cancer Science, EarlyView.
TP‐0903 exerts the antitumor effects through diverse cell‐specific mechanisms, including apoptosis, ferroptosis, and cell cycle disruption. These insights underline the potential of TP‐0903 as a therapeutic agent for hematological malignancies and emphasize the need for further research to fully elucidate the molecular targets of TP‐0903 and optimize ...
Tomoko Kimura‐Hyoda, Mikuri Ryu, Ryosuke Yuta, Saori Fukumoto, Kentaro Hosokawa, Hisayuki Yao, Yoko Yasuda, Koichi Miura, Kaoru Tohyama, Fumio Arai, Takeshi Uchiumi   +10 more
wiley   +1 more source

CDK1 in the driving seat [PDF]

Nature Reviews Molecular Cell Biology, 2007
openaire   +1 more source

Super‐Enhancer Target Gene CBP/p300‐Interacting Transactivator With Glu/Asp‐Rich C‐Terminal Domain, 2 Cooperates With Transcription Factor Forkhead Box J3 to Inhibit Pulmonary Vascular Remodeling

Cell Proliferation, EarlyView.
During hypoxia, the transcriptional effect of super‐enhancer in promoting CBP/p300‐interacting transactivator with Glu/Asp‐rich C‐terminal domain, 2 reduced, eventually leading to the thickening of the smooth muscle layer of the pulmonary artery.
Songyue Li, Jingya Zhang, Xu Wang, Xinru Wang, Yuyu Song, Xinyue Song, Xiuli Wang, Weiwei Cao, Chong Zhao, Jing Qi, Xiaodong Zheng, Yan Xing   +11 more
wiley   +1 more source

Rapid and Effective Neuronal Conversion of Human Glioblastoma In Vitro and In Vivo Using Potent Small Molecules

Cell Proliferation, EarlyView.
A potent combination of small molecules YFSS (Y27632, Forskolin, SB431542, SP600125) that were screened through a neuronal‐specific promoter–reporter system TUBB3::mCherry effectively induces neuronal‐GBM conversion in vitro and in vivo, unveiling molecular mechanisms that offer a theoretical basis and a potential therapeutic strategy for treating GBM.
Ya'nan Hu, Jinming Liu, Jian Tu, Min Yang, Qisheng He, Fei Li, Xiaojing Xu, Zhongqing Ji, Jianwei Xu, Wentao Zhong, Mengwen Yan, Ying Yang, Huanxiang Zhang   +12 more
wiley   +1 more source

The p53-targeting human phosphatase hCdc14A interacts with the Cdk1/cyclin B complex and is differentially expressed in human cancers [PDF]

, 2006
Michelle T. Paulsen, Adrienne M. Starks, Frederick A. Derheimer, Sheela Hanasoge, Liwu Li, Jack E. Dixon, Mats Ljungman   +6 more
openalex   +3 more sources