Results 211 to 220 of about 67,859 (329)
SKIL Promotes Pancreatic Cancer Metastasis by Inhibiting TSPYL2 to Activate the TGF‐β Pathway
Cancer Innovation, Volume 4, Issue 3, June 2025.The elevated expression of the SKIL gene is associated with poor prognosis in pancreatic cancer patients. High SKIL expression activates the TGF‐β pathway by inhibiting the expression of the TSPYL2 gene, subsequently inducing the epithelial–mesenchymal transition (EMT) through the downregulation of E‐cadherin expression and the upregulation of Vimentin
Chenxi Wang +6 more
wiley +1 more source
Fbx7 Functions in the SCF Complex Regulating Cdk1-Cyclin B-phosphorylated Hepatoma Up-regulated Protein (HURP) Proteolysis by a Proline-rich Region [PDF]
, 2004 Jung-Mao Hsu +3 more
openalex +1 more source
Recent Findings in N6‐Methyladenosine Modification and Significance in Pancreatic Cancer
Cancer Medicine, Volume 14, Issue 11, June 2025.ABSTRACT Background RNA modifications are widely detected in cells and are involved in RNA structural stabilization and regulation of gene expression. In cancer cells, RNA modifications are altered, resulting in abnormal expression of numerous genes and promoting cancer growth. N1‐methyladenosine (m1A), N6‐methyladenosine (m6A), N3‐methylcytosine (m3C),
Tomoaki Hara +8 more
wiley +1 more source
Control of DNA Synthesis and Mitosis by the Skp2-p27-Cdk1/2 Axis [PDF]
, 2004 Michele Pagano
openalex +1 more source
Recombinant cyclin B-Cdk1-Suc1 capable of multi-site mitotic phosphorylation in vitro.
PLoS ONECyclin-dependent kinase 1 (Cdk1) complexed with cyclin B phosphorylates multiple sites on hundreds of proteins during mitosis. However, it is not fully understood how multi-site mitotic phosphorylation by cyclin B-Cdk1 controls the structures and ...
Keishi Shintomi +4 more
doaj +1 more source
International Journal of Cancer, Volume 156, Issue 11, Page 2237-2250, 1 June 2025.What's new? The remarkably poor prognosis of metastasized soft tissue sarcoma (STS) has motivated a search for novel biomarkers and therapeutic approaches. A promising candidate biomarker is H2A histone family member X (H2AX), a key player in DNA damage detection and repair pathways.
Adrian Georg Simon +14 more
wiley +1 more source
Cyclin A/Cdk2 complexes regulate activation of Cdk1 and Cdc25 phosphatases in human cells [PDF]
, 2004 Jayashree Mitra, Greg H. Enders
openalex +1 more source
CXXC5 is a ubiquitinated protein and is degraded by the ubiquitin‐proteasome pathway
Protein Science, Volume 34, Issue 6, June 2025.Abstract CXXC5, as a member of the zinc‐finger CXXC family proteins, interacts with unmodified CpG dinucleotides to modulate the expression of genes involved in cellular proliferation, differentiation, and death in physiology and pathophysiology. Various signaling pathways, including mitogenic 17β‐estradiol (E2), contribute to the expression and ...
Hazal Ayten +10 more
wiley +1 more source