Results 21 to 30 of about 67,859 (329)
Rescue of a Human Cell Line from Endogenous Cdk1 Depletion by Cdk1 Lacking Inhibitory Phosphorylation Sites [PDF]
Journal of Biological Chemistry, 2007 Cells that transiently overexpress cyclin-dependent kinase 1 lacking inhibitory phosphorylation sites (Cdk1-AF) undergo premature and catastrophic mitosis, reflecting the key role for Cdk1 in promoting a timely transit from G(2) into mitosis. Conversely, cells depleted of Cdk1 undergo repeated S phases without intervening mitoses (endoreduplication ...
Andrew C.G. Porter +2 more
openaire +5 more sources
Phosphorylation of Ubc9 by Cdk1 enhances SUMOylation activity. [PDF]
PLoS ONE, 2012 Increasing evidence has pointed to an important role of SUMOylation in cell cycle regulation, especially for M phase. In the current studies, we have obtained evidence through in vitro studies that the master M phase regulator CDK1/cyclin B kinase ...
Yee-Fun Su +4 more
doaj +5 more sources
Identification and validation of CDK1 as a promising therapeutic target for Eriocitrin in colorectal cancer: a combined bioinformatics and experimental approach [PDF]
BMC CancerBackground Colorectal cancer (CRC) is a prevalent malignancy worldwide, associated with significant morbidity and mortality. Cyclin-dependent kinase 1 (CDK1) plays a crucial role in cell cycle regulation and has been implicated in various cancers.
Jiemiao Shen +7 more
doaj +2 more sources
CARM1 S217 phosphorylation by CDK1 in late G2 phase facilitates mitotic entry [PDF]
Cell Death and DiseaseThe coactivator-associated arginine methyltransferase 1 (CARM1) functions as an epigenetic writer, however, its role in mitosis remains poorly understood.
Yena Cho +3 more
doaj +2 more sources
Prognostic significance of CDK1 expression in diffuse large B-Cell lymphoma [PDF]
BMC CancerBackground Diffuse large B-cell lymphoma (DLBCL) is the most common lymphoma in adult, characterized by uncontrolled cell proliferation and strong aggressiveness.
Qiuni Chen +7 more
doaj +2 more sources
Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions
Advancement of science, 2023 Triple‐negative breast cancer (TNBC) is a highly lethal malignancy with limited therapy options. TWIST1, a key transcriptional factor of epithelial‐mesenchymal transition (EMT), contributes to self‐renewal of cancer stem‐like cells (CSCs), chemo ...
Tangming Guan +14 more
semanticscholar +1 more source
CENP-C Phosphorylation by CDK1 in vitro [PDF]
BIO-PROTOCOL, 2021 Accurate chromosome segregation during mitosis requires the kinetochore, a large protein complex, which makes a linkage between chromosomes and spindle microtubes. An essential kinetochore component, CENP-C, is phosphorylated by Cyclin-B-Cyclin dependent kinase 1 (CDK1) that is a master kinase for mitotic progression, promoting proper kinetochore ...
Tatsuo Fukagawa +3 more
openaire +4 more sources
Deubiquitylase YOD1 regulates CDK1 stability and drives triple-negative breast cancer tumorigenesis
Journal of experimental & clinical cancer research : CR, 2023 Background Accumulating evidence has demonstrated that aberrant expression of deubiquitinating enzymes is associated with the initiation and progression of Triple-negative breast cancer (TNBC).
Zhi-tao Han +15 more
semanticscholar +1 more source
Journal of Translational Medicine, 2022 Background Adrenocortical carcinoma (ACC) is an extremely rare, aggressive tumor with few effective therapeutic options or drugs. Mitotane (Mtn), which is the only authorized therapeutic drug, came out in 1970 and is still the only first-line treatment ...
Li-wen Ren +13 more
semanticscholar +1 more source
Ultrasensitivity in the Regulation of Cdc25C by Cdk1 [PDF]
Molecular Cell, 2011 Cdc25C is a critical component of the interlinked positive and double-negative feedback loops that constitute the bistable mitotic trigger. Computational studies have indicated that the trigger's bistability should be more robust if the individual legs of the loops exhibit ultrasensitive responses. Here, we show that in Xenopus extracts two measures of
Nicole B. Trunnell +3 more
openaire +3 more sources