Results 21 to 30 of about 69,053 (332)
International Journal of Molecular Sciences, 2022 The cyclin-dependent kinase Cdk1 is best known for its function as master regulator of the cell cycle. It phosphorylates several key proteins to control progression through the different phases of the cell cycle.
J. Enserink, Pierre Chymkowitch
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Ultrasensitivity in the Regulation of Cdc25C by Cdk1 [PDF]
Molecular Cell, 2011 Cdc25C is a critical component of the interlinked positive and double-negative feedback loops that constitute the bistable mitotic trigger. Computational studies have indicated that the trigger's bistability should be more robust if the individual legs of the loops exhibit ultrasensitive responses. Here, we show that in Xenopus extracts two measures of
Nicole B. Trunnell +3 more
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An Integrative Human Pan-Cancer Analysis of Cyclin-Dependent Kinase 1 (CDK1)
Cancers, 2022 Simple Summary Cyclin-dependent kinase 1 (CDK1), one of the key regulators of the G2/M checkpoint, is expressed in many cells and plays an important role in cell cycle control. However, CDK1 expression is substantially increased in many tumors of diverse
Xuanyou Liu, Hao Wu, Zhenguo Liu
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CDK1, the Other ‘Master Regulator’ of Autophagy [PDF]
Trends in Cell Biology, 2021 Autophagy and cap-dependent mRNA translation are tightly regulated by the mechanistic target of rapamycin complex 1 (mTORC1) signalling complex in response to nutrient availability. However, the regulation of these processes, and mTORC1 itself, is different during mitosis, and this has remained an area of significant controversy; for example, studies ...
Richard I. Odle +3 more
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CDK1–cyclin-B1-induced kindlin degradation drives focal adhesion disassembly at mitotic entry
Nature Cell Biology, 2022 The disassembly of integrin-containing focal adhesions (FAs) at mitotic entry is essential for cell rounding, mitotic retraction fibre formation, bipolar spindle positioning and chromosome segregation.
Nan-Peng Chen, Jonas Aretz, R. Fässler
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Inhibition of CDK1 activity by sumoylation [PDF]
Biochemical and Biophysical Research Communications, 2016 Sumoylation (a covalent modification by Small Ubiquitin-like Modifiers or SUMO proteins) has been implicated in the regulation of various cellular events including cell cycle progression. We have recently identified CDK1, a master regulator of mitosis and meiosis, as a SUMO target both in vivo and in vitro, supporting growing evidence concerning a ...
Yuxuan Xiao +4 more
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Cdk1: Unsung Hero of S Phase? [PDF]
Cell Cycle, 2004 Cdk2 has been viewed as a key cell cycle regulator that is essential for S phase progression. The recent discovery that Cdk2 is not required for cell proliferation in mice now shows that other factors must be able to replace Cdk2 in stimulating DNA replication.
Marcin Pacek +2 more
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Rescue of a Human Cell Line from Endogenous Cdk1 Depletion by Cdk1 Lacking Inhibitory Phosphorylation Sites [PDF]
Journal of Biological Chemistry, 2006 Cells that transiently overexpress cyclin-dependent kinase 1 lacking inhibitory phosphorylation sites (Cdk1-AF) undergo premature and catastrophic mitosis, reflecting the key role for Cdk1 in promoting a timely transit from G(2) into mitosis. Conversely, cells depleted of Cdk1 undergo repeated S phases without intervening mitoses (endoreduplication ...
Mita Gupta +2 more
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Systematic Pan-Cancer Analysis Identifies CDK1 as an Immunological and Prognostic Biomarker
Journal of Oncology, 2022 Cyclin-dependent kinase 1 (CDK1) plays an important role in cancer development, progression, and the overall process of tumorigenesis. However, no pan-cancer analysis has been reported for CDK1, and the predictive role of CDK1 in immune checkpoint ...
Yaqi Yang +8 more
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An overview of Cdk1-controlled targets and processes [PDF]
Cell Division, 2010 The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the model organism S. cerevisiae. Research performed during the past decade has significantly improved our understanding of the molecular machinery of the cell cycle.
Enserink, Jorrit M, Kolodner, Richard D
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