Results 31 to 40 of about 69,053 (332)
Experimental and Molecular Medicine, 2022 Aberrant activation of embryogenesis-related molecular programs in urothelial bladder cancer (BC) is associated with stemness features related to oncogenic dedifferentiation and tumor metastasis. Recently, we reported that overexpression of transcription
Jinbeom Heo +15 more
semanticscholar +1 more source
Sensitivity to cdk1-inhibition is modulated by p53 status in preclinical models of embryonal tumors [PDF]
, 2015 Dysregulation of the cell cycle and cyclin-dependent kinases (cdks) is a hallmark of cancer cells. Intervention with cdk function is currently evaluated as a therapeutic option in many cancer types including neuroblastoma (NB), a common solid tumor of ...
Eggert, Angelika +8 more
core +5 more sources
Cyclin A and Cks1 promote kinase consensus switching to non-proline directed CDK1 phosphorylation
bioRxiv, 2022 Ordered protein phosphorylation by CDKs is a key mechanism for regulating the cell cycle. How temporal order is enforced in mammalian cells remains unclear.
Aymen Al-Rawi +3 more
semanticscholar +1 more source
Cell & Bioscience, 2023 Background Pancreatic cancer stem cells (CSCs) promote pancreatic ductal adenocarcinoma (PDAC) tumorigenesis and chemoresistance. Cyclin-dependent kinase 1 (CDK1) plays an important role in tumor initiation in other tumors, but the function of CDK1 in ...
Xiaodong Xu +9 more
doaj +1 more source
Journal of Biological Chemistry, 2023 Cyclin A and CDC25A are both activators of cyclin-dependent kinases (CDKs): cyclin A acts as an activating subunit of CDKs and CDC25A a phosphatase of the inhibitory phosphorylation sites of the CDKs. In this study, we uncovered an inverse relationship between the two CDK activators.
Lau Yan Ng, Hoi Tang Ma, Randy Y.C. Poon
openaire +3 more sources
When CDK1 Rides the Telomere Cycle [PDF]
Molecular Cell, 2006 Reconstitution of telomeric DNA at each cell division implies the coordination of DNA semiconservative replication with several processing events still poorly understood. Two reports published recently in Molecular Cell show that a cell-cycle cyclin-dependent kinase, Cdk1p, is required to create the cell-cycle-regulated overhang ().
M. Teresa Teixeira, Eric Gilson
openaire +5 more sources
Timing Is Everything: Regulation of Cdk1 and Aneuploidy [PDF]
Developmental Cell, 2007 The spindle checkpoint ensures the proper partition of the chromosomal content of dividing cells, by controlling the transition from metaphase to anaphase. In a recent issue of Cancer Cell, Vecchione and coworkers report that the protein product of the tumor suppressor gene Lzts1 (Leucine zipper tumor suppressor-1) binds the Cdk1 phosphatase Cdc25C and
Philip N. Tsichlis +2 more
openaire +3 more sources
PKM2 Interacts With the Cdk1-CyclinB Complex to Facilitate Cell Cycle Progression in Gliomas
Frontiers in Oncology, 2022 PKM2 is a phosphotyrosine-binding glycolytic enzyme upregulated in many cancers, including glioma, and contributes to tumor growth by regulating cell cycle progression. We noted, however, that in multiple glioma cell lines, PKM2 knock-down resulted in an
Shigeo Ohba +6 more
doaj +1 more source
FEBS Open Bio, 2021 Cyclin‐dependent kinase 1 (CDK1) plays a significant role in certain malignancies. However, it remains unclear whether CDK1 plays a role in esophageal squamous cell carcinoma (ESCC).
Han‐Jie Zhang +8 more
doaj +1 more source
Aging, 2021 Colorectal cancer (CRC) is a prevalent malignancy worldwide. The development of genome sequencing technology has allowed the discovery that epigenetic regulation might play a critical role in CRC tumorigenesis.
Zhongyi Zhou +6 more
semanticscholar +1 more source