Results 31 to 40 of about 67,859 (329)
CDK1, the Other ‘Master Regulator’ of Autophagy [PDF]
Trends in Cell Biology, 2021 Autophagy and cap-dependent mRNA translation are tightly regulated by the mechanistic target of rapamycin complex 1 (mTORC1) signalling complex in response to nutrient availability. However, the regulation of these processes, and mTORC1 itself, is different during mitosis, and this has remained an area of significant controversy; for example, studies ...
Richard I. Odle +3 more
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International Journal of Molecular Sciences, 2022 The cyclin-dependent kinase Cdk1 is best known for its function as master regulator of the cell cycle. It phosphorylates several key proteins to control progression through the different phases of the cell cycle.
J. Enserink, Pierre Chymkowitch
semanticscholar +1 more source
Inhibition of CDK1 activity by sumoylation [PDF]
Biochemical and Biophysical Research Communications, 2016 Sumoylation (a covalent modification by Small Ubiquitin-like Modifiers or SUMO proteins) has been implicated in the regulation of various cellular events including cell cycle progression. We have recently identified CDK1, a master regulator of mitosis and meiosis, as a SUMO target both in vivo and in vitro, supporting growing evidence concerning a ...
Yuxuan Xiao +4 more
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CDK1–cyclin-B1-induced kindlin degradation drives focal adhesion disassembly at mitotic entry
Nature Cell Biology, 2022 The disassembly of integrin-containing focal adhesions (FAs) at mitotic entry is essential for cell rounding, mitotic retraction fibre formation, bipolar spindle positioning and chromosome segregation.
Nan-Peng Chen, Jonas Aretz, R. Fässler
semanticscholar +1 more source
An Integrative Human Pan-Cancer Analysis of Cyclin-Dependent Kinase 1 (CDK1)
Cancers, 2022 Simple Summary Cyclin-dependent kinase 1 (CDK1), one of the key regulators of the G2/M checkpoint, is expressed in many cells and plays an important role in cell cycle control. However, CDK1 expression is substantially increased in many tumors of diverse
Xuanyou Liu, Hao Wu, Zhenguo Liu
semanticscholar +1 more source
Cdk1: Unsung Hero of S Phase? [PDF]
Cell Cycle, 2004 Cdk2 has been viewed as a key cell cycle regulator that is essential for S phase progression. The recent discovery that Cdk2 is not required for cell proliferation in mice now shows that other factors must be able to replace Cdk2 in stimulating DNA replication.
Marcin Pacek +2 more
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Experimental and Molecular Medicine, 2022 Aberrant activation of embryogenesis-related molecular programs in urothelial bladder cancer (BC) is associated with stemness features related to oncogenic dedifferentiation and tumor metastasis. Recently, we reported that overexpression of transcription
Jinbeom Heo +15 more
semanticscholar +1 more source
An overview of Cdk1-controlled targets and processes [PDF]
Cell Division, 2010 The cyclin dependent kinase Cdk1 controls the cell cycle, which is best understood in the model organism S. cerevisiae. Research performed during the past decade has significantly improved our understanding of the molecular machinery of the cell cycle.
Enserink, Jorrit M, Kolodner, Richard D
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Systematic Pan-Cancer Analysis Identifies CDK1 as an Immunological and Prognostic Biomarker
Journal of Oncology, 2022 Cyclin-dependent kinase 1 (CDK1) plays an important role in cancer development, progression, and the overall process of tumorigenesis. However, no pan-cancer analysis has been reported for CDK1, and the predictive role of CDK1 in immune checkpoint ...
Yaqi Yang +8 more
semanticscholar +1 more source
Cyclin A and Cks1 promote kinase consensus switching to non-proline directed CDK1 phosphorylation
bioRxiv, 2022 Ordered protein phosphorylation by CDKs is a key mechanism for regulating the cell cycle. How temporal order is enforced in mammalian cells remains unclear.
Aymen Al-Rawi +3 more
semanticscholar +1 more source