Results 41 to 50 of about 69,053 (332)

CDC6 as a Key Inhibitory Regulator of CDK1 Activation Dynamics and the Timing of Mitotic Entry and Progression

Biology, 2023
Timely mitosis is critically important for early embryo development. It is regulated by the activity of the conserved protein kinase CDK1. The dynamics of CDK1 activation must be precisely controlled to assure physiologic and timely entry into mitosis ...
Mohammed El Dika, Damian Dudka, Malgorzata Kloc, Jacek Z. Kubiak   +3 more
doaj   +1 more source

Cascades of multisite phosphorylation control Sic1 destruction at the onset of S phase. [PDF]

, 2011
Multisite phosphorylation of proteins has been proposed to transform a graded protein kinase signal into an ultrasensitive switch-like response. Although many multiphosphorylated targets have been identified, the dynamics and sequence of individual ...
Balog, Eva Rose M, Iofik, Anna, Kõivomägi, Mardo, Lepiku, Martin, Loog, Mart, Morgan, David O, Rubin, Seth M, Valk, Ervin, Venta, Rainis   +8 more
core   +2 more sources

Global phosphoproteomics reveals DYRK1A regulates CDK1 activity in glioblastoma cells

Cell Death Discovery, 2021
Both tumour suppressive and oncogenic functions have been reported for dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A). Herein, we performed a detailed investigation to delineate the role of DYRK1A in glioblastoma.
A. Recasens, Sean J. Humphrey, Michael Ellis, Monira Hoque, Ramzi H. Abbassi, Brianna Chen, Mitchell Longworth, E. Needham, D. James, T. Johns, B. Day, M. Kassiou, Pengyi Yang, L. Munoz   +13 more
semanticscholar   +1 more source

Nuclear lamin phosphorylation: an emerging role in gene regulation and pathogenesis of laminopathies

Nucleus, 2020
Decades of studies have established that nuclear lamin polymers form the nuclear lamina, a protein meshwork that supports the nuclear envelope structure and tethers heterochromatin to the nuclear periphery.
Sunny Yang Liu, Kohta Ikegami
doaj   +1 more source

Phosphorylation of the androgen receptor at Ser81 is co‐sustained by CDK1 and CDK9 and leads to AR‐mediated transactivation in prostate cancer

Molecular Oncology, 2021
Androgen receptor (AR) is the principal molecule in prostate cancer (PCa) etiology and therapy. AR re‐activation still remains a major challenge during treatment of castration‐resistant prostate cancer (CRPC) tumors that relapse after castration ...
Xintao Gao, Jiaqian Liang, Liyang Wang, Zhaoyang Zhang, Penghui Yuan, Jiaxin Wang, Yanfei Gao, Fen Ma, Carla Calagua, Huihui Ye, O. Voznesensky, Shaogang Wang, Tao Wang, Jihong Liu, Shaoyong Chen, Xiaming Liu   +15 more
semanticscholar   +1 more source

Cyclin B Export to the Cytoplasm via the Nup62 Subcomplex and Subsequent Rapid Nuclear Import Are Required for the Initiation of Drosophila Male Meiosis

Cells, 2023
The cyclin-dependent kinase 1 (Cdk1)–cyclin B (CycB) complex plays critical roles in cell-cycle regulation. Before Drosophila male meiosis, CycB is exported from the nucleus to the cytoplasm via the nuclear porin 62kD (Nup62) subcomplex of the nuclear ...
Kanta Yamazoe, Yoshihiro H. Inoue
doaj   +1 more source

USP7 limits CDK1 activity throughout the cell cycle

EMBO Journal, 2021
Chemical inhibitors of the deubiquitinase USP7 are currently being developed as anticancer agents based on their capacity to stabilize P53. Regardless of this activity, USP7 inhibitors also generate DNA damage in a p53‐independent manner.
A. Galarreta, P. Valledor, Patricia Ubieto-Capella, V. Lafarga, E. Zarzuela, J. Muñoz, Marcos Malumbres, E. Lecona, O. Fernández-Capetillo   +8 more
semanticscholar   +1 more source

Androgen receptor phosphorylation at serine 515 by Cdk1 predicts biochemical relapse in prostate cancer patients [PDF]

, 2013
<br>Background:Prostate cancer cell growth is dependent upon androgen receptor (AR) activation, which is regulated by specific kinases. The aim of the current study is to establish if AR phosphorylation by Cdk1 or ERK1/2 is of prognostic ...
BV Kallakury, C E Adams, C Tannahill, D Gioeli, D Gioeli, G Fyffe, GG Kuiper, H Y Leung, H Zong, HY Wong, J Edwards, J Ferlay, J M Willder, JC Obenauer, JS Diallo, K Shigemura, KS McCarty, LA Ponguta, LJ Blok, M A Underwood, M Mistry, M Roach, M Seywright, MS Cookson, NG Anderson, P Chymkowitch, P G Horgan, P McCall, R Mukherjee, RE Bakin, RK Tyagi, S Chen, S Chen, S J Heng, SM Powell, T Kirkegaard, T Ohta, WC Bell, Y Wen, Z Fu, ZX Zhou   +40 more
core   +1 more source

CDK1, CCNB1, and CCNB2 are Prognostic Biomarkers and Correlated with Immune Infiltration in Hepatocellular Carcinoma

Medical Science Monitor, 2020
Background Orderly G2/M transition in the cell cycle is controlled by the cyclin-dependent kinase 1/cyclin B (CDK1/CCNB) complex. We aimed to comprehensively investigate the roles of CDK1, CCNB1, and CCNB2 via multi-omics analysis and their relationships
Yiping Zou, Shiye Ruan, L. Jin, Zhihong Chen, Hongwei Han, Yuanpeng Zhang, Z. Jian, Ye Lin, N. Shi, Haosheng Jin   +9 more
semanticscholar   +1 more source

Positive Feedback Keeps Duration of Mitosis Temporally Insulated from Upstream Cell-Cycle Events [PDF]

, 2016
Cell division is characterized by a sequence of events by which a cell gives rise to two daughter cells. Quantitative measurements of cell-cycle dynamics in single cells showed that despite variability in G1-, S-, and G2 phases, duration of mitosis is ...
Araujo, AR, Gelens, L, Santos, S, Sheriff, RSM   +3 more
core   +1 more source