Expression and prognostic value of CDK1, CCNA2, and CCNB1 gene clusters in human breast cancer
Journal of International Medical Research, 2021 Objective Cell cycle-associated proteins play important roles in breast cancer (BRCA), based on evidence from cell lines, preclinical murine models, and human tissue samples.
Z. Xing +5 more
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Cdk1 inactivation terminates mitotic checkpoint surveillance and stabilizes kinetochore attachments in anaphase [PDF]
, 2014 Two mechanisms safeguard the bipolar attachment of chromosomes in mitosis. A correction mechanism destabilizes erroneous attachments that do not generate tension across sister kinetochores [1].
Amalie E. Dick +36 more
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Cdk1 restrains NHEJ through phosphorylation of XRCC4-like factor Xlf1 [PDF]
, 2014 Eukaryotic cells use two principal mechanisms for repairing DNA double-strand breaks (DSBs): homologous recombination (HR) and nonhomologous end-joining (NHEJ). DSB repair pathway choice is strongly regulated during the cell cycle.
Almeida +21 more
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Regulation of sororin by Cdk1-mediated phosphorylation [PDF]
Journal of Cell Science, 2011 Tumor cells are commonly aneuploid, a condition contributing to cancer progression and drug resistance. Understanding how chromatids are linked and separated at the appropriate time will help uncover the basis of aneuploidy and will shed light on the behavior of tumor cells.
William R. Taylor +2 more
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Frontiers in Oncology, 2021 Dihydroartemisinin (DHA), a well-known antimalarial drug, has been widely investigated for its antitumor effects in multiple malignancies. However, its effects and regulatory mechanisms in colorectal cancer (CRC) are still unproved.
You-Cai Yi +6 more
semanticscholar +1 more source
Cancer Management and Research, 2021 Deng YR, Chen XJ, Chen W, et al. Cancer Manag Res. 2019;11:5835–5844. The authors have advised due to an error at the time of figure assembly, Figure 3A on page 5840 is incorrect. The correct Figure 3 is shown in Download Article.
Deng YR +8 more
doaj
Multisite phosphorylation networks as signal processors for Cdk1 [PDF]
Nature Structural & Molecular Biology, 2013 The order and timing of cell-cycle events is controlled by changing substrate specificity and different activity thresholds of cyclin-dependent kinases (CDKs). However, it is not understood how a single protein kinase can trigger hundreds of switches in a sufficiently time-resolved fashion.
Kõivomägi, Mardo +9 more
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Suppression of Vimentin Phosphorylation by the Avian Reovirus p17 through Inhibition of CDK1 and Plk1 Impacting the G2/M Phase of the Cell Cycle. [PDF]
PLoS ONE, 2016 The p17 protein of avian reovirus (ARV) causes cell cycle retardation in a variety of cell lines; however, the underlying mechanism(s) by which p17 regulates the cell cycle remains largely unknown.
Hung-Chuan Chiu +6 more
doaj +1 more source
Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae
eLife, 2022 Cdc6, a subunit of the pre-replicative complex (pre-RC), contains multiple regulatory cyclin-dependent kinase (Cdk1) consensus sites, SP or TP motifs. In Saccharomyces cerevisiae, Cdk1 phosphorylates Cdc6-T7 to recruit Cks1, the Cdk1 phospho-adaptor in S
Jasmin Philip +7 more
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Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells [PDF]
, 2014 Background Although MYC is an attractive therapeutic target for breast cancer treatment, it has proven challenging to inhibit MYC directly, and clinically effective pharmaceutical agents targeting MYC are not yet available. An alternative approach is to
Kang, Jian +3 more
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