Results 61 to 70 of about 69,053 (332)

Cdk1 and SUMO Regulate Swe1 Stability

PLoS ONE, 2010
The Swe1/Wee1 kinase phosphorylates and inhibits Cdk1-Clb2 and is a major mitotic switch. Swe1 levels are controlled by ubiquitin mediated degradation, which is regulated by interactions with various mitotic kinases. We have recently reported that Swe1 levels are capable of sensing the progress of the cell cycle by measuring the levels of Cdk1-Clb2 ...
Kobi J. Simpson-Lavy, Michael Brandeis
openaire   +5 more sources

Sp1 Contributes to Radioresistance of Cervical Cancer Through Targeting G2/M Cell Cycle Checkpoint CDK1 [Corrigendum]

Cancer Management and Research, 2021
Deng YR, Chen XJ, Chen W, et al. Cancer Manag Res. 2019;11:5835–5844. The authors have advised due to an error at the time of figure assembly, Figure 3A on page 5840 is incorrect. The correct Figure 3 is shown in Download Article.
Deng YR, Chen XJ, Chen W, Wu LF, Jiang HP, Lin D, Wang LJ, Wang W, Guo SQ   +8 more
doaj  

Expression and prognostic value of CDK1, CCNA2, and CCNB1 gene clusters in human breast cancer

Journal of International Medical Research, 2021
Objective Cell cycle-associated proteins play important roles in breast cancer (BRCA), based on evidence from cell lines, preclinical murine models, and human tissue samples.
Z. Xing, Xin Wang, Jiaqi Liu, Menglu Zhang, K. Feng, Xiang Wang   +5 more
semanticscholar   +1 more source

Phosphorylation of survivin at threonine 34 inhibits its mitotic function and enhances its cytoprotective activity [PDF]

, 2009
Survivin is an essential chromosomal passenger protein required for mitotic progression. It is also an inhibitor of apoptosis and can prevent caspase-mediated cell death.
Barrett, Rachel M.A., Osborne, Toby P., Wheatley, Sally P.   +2 more
core   +1 more source

Suppression of Vimentin Phosphorylation by the Avian Reovirus p17 through Inhibition of CDK1 and Plk1 Impacting the G2/M Phase of the Cell Cycle. [PDF]

PLoS ONE, 2016
The p17 protein of avian reovirus (ARV) causes cell cycle retardation in a variety of cell lines; however, the underlying mechanism(s) by which p17 regulates the cell cycle remains largely unknown.
Hung-Chuan Chiu, Wei-Ru Huang, Tsai-Ling Liao, Hung-Yi Wu, Muhammad Munir, Wing-Ling Shih, Hung-Jen Liu   +6 more
doaj   +1 more source

Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae

eLife, 2022
Cdc6, a subunit of the pre-replicative complex (pre-RC), contains multiple regulatory cyclin-dependent kinase (Cdk1) consensus sites, SP or TP motifs. In Saccharomyces cerevisiae, Cdk1 phosphorylates Cdc6-T7 to recruit Cks1, the Cdk1 phospho-adaptor in S
Jasmin Philip, Mihkel Örd, Andriele Silva, Shaneen Singh, John FX Diffley, Dirk Remus, Mart Loog, Amy E Ikui   +7 more
doaj   +1 more source

Dihydroartemisinin Suppresses the Tumorigenesis and Cycle Progression of Colorectal Cancer by Targeting CDK1/CCNB1/PLK1 Signaling

Frontiers in Oncology, 2021
Dihydroartemisinin (DHA), a well-known antimalarial drug, has been widely investigated for its antitumor effects in multiple malignancies. However, its effects and regulatory mechanisms in colorectal cancer (CRC) are still unproved.
You-Cai Yi, Rui Liang, Xiaoyu Chen, Huijuan Fan, Ming Chen, Jing Zhang, Jinshui Zhu   +6 more
semanticscholar   +1 more source

Phosphorylation of eIF4GII and 4E-BP1 in response to nocodazole treatment: a reappraisal of translation initiation during mitosis [PDF]

, 2013
Translation mechanisms at different stages of the cell cycle have been studied for many years, resulting in the dogma that translation rates are slowed during mitosis, with cap-independent translation mechanisms favored to give expression of key ...
Abbie Mead, Bonneau, Bradley, Bushell, Byrd, Carmena, Clemens, Coldwell, Coldwell, Coldwell, Dobrikov, Elia, Fadden, Fan, Franz-Wachtel, Gingras, Gingras, Gradi, Harrison, Heesom, Heesom, Hinton, Jackson, Jang, Joanne Cowan, Kim, Laplante, Lisa Perry, Ma, Margalit, Marissen, Mark Coldwell, Mark Willett, Markete Vlasak, Morley, Morris, Nagano, Pasquier, Perez, Proud, Pyronnet, Pyronnet, Qin, Qin, Shevchenko, Simon Morley, Singh, Skop, Smith, Sonenberg, Tinton, Vassilev, Wek, Whitfield, Wurzenberger, Xue   +55 more
core   +1 more source

Multisite phosphorylation networks as signal processors for Cdk1 [PDF]

Nature Structural & Molecular Biology, 2013
The order and timing of cell-cycle events is controlled by changing substrate specificity and different activity thresholds of cyclin-dependent kinases (CDKs). However, it is not understood how a single protein kinase can trigger hundreds of switches in a sufficiently time-resolved fashion.
Kõivomägi, Mardo, Örd, Mihkel, Iofik, Anna, Valk, Ervin, Venta, Rainis, Faustova, Ilona, Kivi, Rait, Balog, Eva Rose M, Rubin, Seth M, Loog, Mart   +9 more
openaire   +5 more sources

Cycling in synchrony [PDF]

, 2019
The corn smut fungus uses two different mechanisms to control its cell cycle when it is infecting ...
Bardetti, Chang, Fukada, Li, Müller, Nurse, Osés-Ruiz, Savary, Urban   +8 more
core   +1 more source