Results 81 to 90 of about 67,859 (329)
Brain-derived neurotrophic factor-dependent cdk1 inhibition prevents G2/M progression in differentiating tetraploid neurons. [PDF]
PLoS ONE, 2013 Neurodegeneration is often associated with DNA synthesis in neurons, the latter usually remaining for a long time as tetraploid cells before dying by apoptosis.
María C Ovejero-Benito, José M Frade
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CDK1 controls CHMP7-dependent nuclear envelope reformation [PDF]
eLife, 2020 Through membrane sealing and disassembly of spindle microtubules, the Endosomal Sorting Complex Required for Transport-III (ESCRT-III) machinery has emerged as a key player in the regeneration of a sealed nuclear envelope (NE) during mitotic exit, and in the repair of this organelle during interphase rupture.
Caroline L Stoten +9 more
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Cancer Management and Research, 2020 Suying Lu,1,2,* Chengtao Sun,3,* Huimou Chen,1,2,* Chao Zhang,1,4,* Wei Li,5 Liuhong Wu,1,2 Jia Zhu,1,2 Feifei Sun,1,2 Junting Huang,1,2 Juan Wang,1,2 Zijun Zhen,1,2 Ruiqing Cai,1,2 Xiaofei Sun,1,2 Yizhuo Zhang,1,2 Xing Zhang1,6 1State Key Laboratory of ...
Lu S +14 more
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Compartmentalized control of Cdk1 drives mitotic spindle assembly
Cell Reports, 2022 Summary: During cell division, dramatic microtubular rearrangements driven by cyclin B-cdk1 (Cdk1) kinase activity mark the onset of mitosis leading to dismantling of the interphase microtubular cytoskeleton and assembly of the mitotic spindle.
Angela Flavia Serpico +3 more
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Phosphorylation of MCPH1 isoforms during mitosis followed by isoform‐specific degradation by APC/C‐CDH1 [PDF]
, 2019 Microcephalin‐1 (MCPH1) exists as 2 isoforms that regulate cyclin‐dependent kinase‐1 activation and chromosome condensation during mitosis, with MCPH1 mutations causing primary microcephaly.
Blain, Peter G. +5 more
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Control of Cdc28 CDK1 by a Stress-Induced lncRNA [PDF]
Molecular Cell, 2014 Genomic analysis has revealed the existence of a large number of long noncoding RNAs (lncRNAs) with different functions in a variety of organisms, including yeast. Cells display dramatic changes of gene expression upon environmental changes. Upon osmostress, hundreds of stress-responsive genes are induced by the stress-activated protein kinase (SAPK ...
Nadal Ribelles, Mariona, 1984- +5 more
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DNA damage induced during mitosis undergoes DNA repair synthesis. [PDF]
, 2020 Understanding the mitotic DNA damage response (DDR) is critical to our comprehension of cancer, premature aging and developmental disorders which are marked by DNA repair deficiencies.
Berns, Michael W +10 more
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Cell cycle specific radiosensitisation by the disulfiram and copper complex [PDF]
, 2017 The disulfiram and copper complex (DSF:Cu) has emerged as a potent radiosensitising anti-cancer agent. The ability of copper to stabilise DSF in a planar conformation and to inhibit DNA replication enzymes stimulated our investigation of the effect of
Anselmi, Giorgio +3 more
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Theranostics, 2018 Rationale: Hepatocellular carcinoma (HCC) is an aggressive malignant solid tumor wherein CDK1/PDK1/β-Catenin is activated, suggesting that inhibition of this pathway may have therapeutic potential.
Chuan Xing Wu +8 more
semanticscholar +1 more source
CDK1 makes the meiotic spindle wait [PDF]
Journal of Cell Biology, 2013 ![Figure][1] In an oocyte with enhanced CDK1 activity, every kinetochore (red) forms a stable, end-on attachment to a spindle microtubule (green). A delay in cyclin-dependent kinase activity prevents meiotic chromosomes from prematurely attaching to spindle microtubules, [Davydenko et ...
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