Results 31 to 40 of about 246,652 (211)
Recent advances in cancer-associated circulating cell-free nucleic acids
Zhongguo aizheng zazhi, 2014 Circulating cell-free nucleic acids are defined as extracellular DNAs or RNAs in blood with physiological or pathological origins. Previous studies showed that the concentration of cell-free nucleic acids in the blood of cancer patients is significantly ...
邢星 +4 more
doaj
Cell-Free Circulating Nucleic Acids as Early Biomarkers for NAFLD and NAFLD-Associated Disorders
Frontiers in Physiology, 2018 Non-alcoholic fatty liver disease (NAFLD) is the worldwide most common cause of chronic liver pathology, which prevalence strongly correlates with the increasing incidence of diabetes, obesity and metabolic syndrome in the general population.
Andrey Turchinovich +8 more
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Denatured mammalian protein mixtures exhibit unusually high solubility in nucleic acid-free pure water. [PDF]
PLoS ONE, 2014 Preventing protein aggregation is a major goal of biotechnology. Since protein aggregates are mainly comprised of unfolded proteins, protecting against denaturation is likely to assist solubility in an aqueous medium.
Junichiro Futami +8 more
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Nature CommunicationsReal-time and continuous monitoring of nucleic acid biomarkers with wearable devices holds potential for personal health management, especially in the context of pandemic surveillance or intensive care unit disease.
Bin Yang +3 more
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Cell-free and intracellular nucleic acids: new non-invasive biomarkers to explore male infertility
Basic and Clinical Andrology, 2017 Résumé L’infertilité masculine est un problème qui touche de nombreux couples. Cependant, aujourd’hui les mécanismes moléculaires et les causes de l’infertilité masculine idiopathique ne sont pas élucidés.
Anne Boissière +7 more
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Cell-free nucleic acids as biomarkers of cardiovascular diseases: prospects and limitations
Российский кардиологический журналOne of the urgent tasks is the search for early and specific markers of cardiovascular diseases (CVD) in order to stratify the cardiovascular risk, develop methods for their prevention, early diagnosis and treatment.
L. O. Korneva +8 more
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Quantitation of cell-free DNA and RNA in plasma during tumor progression in rats
Molecular Cancer, 2013 Background To clarify the implications of cell-free nucleic acids (cfNA) in the plasma in neoplastic disease, it is necessary to determine the kinetics of their release into the circulation.
García-Olmo Dolores C +4 more
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source