Results 11 to 20 of about 246,652 (211)

Virus-Like Cytosolic and Cell-Free Oxidatively Damaged Nucleic Acids Likely Drive Inflammation, Synapse Degeneration, and Neuron Death in Alzheimer’s Disease

Journal of Alzheimer's Disease Reports, 2023
Oxidative stress, inflammation, and amyloid-β are Alzheimer’s disease (AD) hallmarks that cause each other and other AD hallmarks. Most amyloid-β-lowering, antioxidant, anti-inflammatory, and antimicrobial AD clinical trials failed; none stopped or ...
Owen Davis Sanders
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Circulating Cell-free Tumor Nucleic Acids in Gastric Cancer

The Korean Journal of Helicobacter and Upper Gastrointestinal Research, 2018
Gastric cancer is still the leading cause of cancer deaths, especially in Asian countries. Recently, many studies have analyzed cell-free nucleic acids (cfNAs) circulating in the blood, for the early diagnosis of cancer and monitoring its progression ...
Hyun-Ji Lee, Sun Min Lee
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Liquid biopsies for liquid tumors: emerging potential of circulating free nucleic acid evaluation for the management of hematologic malignancies

Cancer Biology & Medicine, 2016
Circulating free nucleic acids; cell free DNA and circulating micro-RNA, are found in the plasma of patients with hematologic and solid malignancies at levels higher than that of healthy individuals.
Jay Hocking, Sridurga Mithraprabhu, Anna Kalff, Andrew Spencer   +3 more
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Plasma GBP2 promoter methylation is associated with advanced stages in breast cancer [PDF]

Genetics and Molecular Biology, 2020
Blood methylated cell-free DNA (cfDNA) as a minimally invasive cancer biomarker has great importance in cancer management. Guanylate binding protein 2 (GBP2) has been considered as a possible controlling factor in tumor development.
Farzaneh Rahvar, Mahdieh Salimi, Hossein Mozdarani   +2 more
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Circulating nucleic acids in the plasma and serum as potential biomarkers in neurological disorders [PDF]

Brazilian Journal of Medical and Biological Research, 2020
Neurological diseases are responsible for approximately 6.8 million deaths every year. They affect up to 1 billion people worldwide and cause significant disability and reduced quality of life.
D.C.F. Bruno, A. Donatti, M. Martin, V.S. Almeida, J.C. Geraldis, F.S. Oliveira, D.B. Dogini, I. Lopes-Cendes   +7 more
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Digital PCR-based evaluation of nucleic acid extraction kit performance for the co-purification of cell-free DNA and RNA

Human Genomics, 2022
Background Blood plasma, one of the most studied liquid biopsies, contains various molecules that have biomarker potential for cancer detection, including cell-free DNA (cfDNA) and cell-free RNA (cfRNA). As the vast majority of cell-free nucleic acids in
Jill Deleu, Kathleen Schoofs, Anneleen Decock, Kimberly Verniers, Sofie Roelandt, Angie Denolf, Joke Verreth, Bram De Wilde, Tom Van Maerken, Katleen De Preter, Jo Vandesompele   +10 more
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Pre-analytical issues in liquid biopsy – where do we stand?

Journal of Laboratory Medicine, 2020
It is well documented that in the chain from sample to the result in a clinical laboratory, the pre-analytical phase is the weakest and most vulnerable link. This also holds for the use and analysis of extracellular nucleic acids.
Fleischhacker Michael, Schmidt Bernd
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An efficient and cost-effective method for purification of small sized DNAs and RNAs from human urine.

PLoS ONE, 2019
Urine holds great promise as a non-invasive sampling method for molecular diagnostics. The cell-free nucleic acids of urine however are small, labile, and difficult to purify.
Kayvan Zainabadi, Vaigundan Dhayabaran, Kutty Moideen, Patnam Krishnaswamy   +3 more
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TLR and NKG2D signaling pathways mediate CS-induced pulmonary pathologies. [PDF]

PLoS ONE, 2013
Long-term exposure to cigarette smoke (CS) can have deleterious effects on lung epithelial cells including cell death and the initiation of inflammatory responses.
Brian W Wortham, Bryan L Eppert, Jennifer L Flury, Sara Morgado Garcia, Michael T Borchers   +4 more
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Evaluation of circulating cell-free nucleic acids in plasma as biomarkers of laryngeal cancer [PDF]

Cellular, Molecular and Biomedical Reports
It has been aimed to compare the level of cell-free nucleic acids (DNA, RNA, and miRNA) concentrations in laryngeal cancer patients with the control group composed of healthy individuals. It has been utilized 46 patients with laryngeal carcinoma who were
Basak Yavuz, Ozge Cil, Akin Cayir
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