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Advancing synthetic biology through cell-free protein synthesis
Computational and Structural Biotechnology Journal, 2023 The rapid development of synthetic biology has enabled the production of compounds with revolutionary improvements in biotechnology. DNA manipulation tools have expedited the engineering of cellular systems for this purpose.
Ke Yue, Junyu Chen, Yingqiu Li, Lei Kai
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Applications for Cell-free Synthetic Biology [PDF]
BIO Web of Conferences, 2023 Cell-free synthetic biology is a flexible and powerful technology that engineers biological systems and parts without using living cells. Their open nature allows reactions to occur in a well-controlled and characterized environment.
Sun Yewei
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Synthetic Biology Goes Cell-Free [PDF]
BMC Biology, 2019 Cell-free systems (CFS) have recently evolved into key platforms for synthetic biology applications. Many synthetic biology tools have traditionally relied on cell-based systems, and while their adoption has shown great progress, the constraints inherent
Aidan Tinafar +2 more
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Editorial: Cell-Free Synthetic Biology [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Jian Li +3 more
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Cell-free synthetic biology: thinking outside the cell. [PDF]
Metab Eng, 2012 Cell-free synthetic biology is emerging as a powerful approach aimed to understand, harness, and expand the capabilities of natural biological systems without using intact cells. Cell-free systems bypass cell walls and remove genetic regulation to enable direct access to the inner workings of the cell.
Hodgman CE, Jewett MC.
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A Streptomyces venezuelae Cell-Free Toolkit for Synthetic Biology [PDF]
ACS Synthetic Biology, 2021 Prokaryotic cell-free coupled transcription-translation (TX-TL) systems are emerging as a powerful tool to examine natural product biosynthetic pathways in a test tube. The key advantages of this approach are the reduced experimental time scales and controlled reaction conditions.
Simon J. Moore +9 more
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Models for Cell-Free Synthetic Biology: Make Prototyping Easier, Better, and Faster [PDF]
Frontiers in Bioengineering and Biotechnology, 2018 Cell-free TX-TL is an increasingly mature and useful platform for prototyping, testing, and engineering biological parts and systems. However, to fully accomplish the promises of synthetic biology, mathematical models are required to facilitate the ...
Mathilde Koch +5 more
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Cell-free protein synthesis for nonribosomal peptide synthetic biology
Frontiers in Natural ProductsPeptide natural products have a wide range of useful applications as pesticides, veterinary agents, pharmaceuticals, and bioproducts. To discover new natural products, manipulate them for analog generation, and to harness the potential of these bioactive
Tien T. Sword +2 more
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An integrated cell‐free metabolic platform for protein production and synthetic biology
Molecular Systems Biology, 2008 Cell‐free systems offer a unique platform for expanding the capabilities of natural biological systems for useful purposes, i.e. synthetic biology. They reduce complexity, remove structural barriers, and do not require the maintenance of cell viability ...
Michael C Jewett +4 more
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Perspective: Solidifying the impact of cell-free synthetic biology through lyophilization. [PDF]
Biochem Eng J, 2018 Pardee K.
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