Results 1 to 10 of about 1,746 (99)

The cell cycle checkpoint inhibitors in the treatment of leukemias [PDF]

Journal of Hematology & Oncology, 2017
The inhibition of the DNA damage response (DDR) pathway in the treatment of cancers has recently reached an exciting stage with several cell cycle checkpoint inhibitors that are now being tested in several clinical trials in cancer patients. Although the
A. Ghelli Luserna di Rora’, I. Iacobucci, G. Martinelli   +2 more
doaj   +4 more sources

DNA damage checkpoint execution and the rules of its disengagement

Frontiers in Cell and Developmental Biology, 2022
Chromosomes are susceptible to damage during their duplication and segregation or when exposed to genotoxic stresses. Left uncorrected, these lesions can result in genomic instability, leading to cells’ diminished fitness, unbridled proliferation or ...
Candice Qiu Xia Yam, Hong Hwa Lim, Hong Hwa Lim, Uttam Surana, Uttam Surana   +4 more
doaj   +1 more source

The ATM-E6AP-MASTL axis mediates DNA damage checkpoint recovery

eLife, 2023
Checkpoint activation after DNA damage causes a transient cell cycle arrest by suppressing cyclin-dependent kinases (CDKs). However, it remains largely elusive how cell cycle recovery is initiated after DNA damage.
Yanqiu Li, Feifei Wang, Xin Li, Ling Wang, Zheng Yang, Zhongsheng You, Aimin Peng   +6 more
doaj   +1 more source

A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint. [PDF]

PLoS Biology, 2010
DNA damage checkpoints arrest cell cycle progression to facilitate DNA repair. The ability to survive genotoxic insults depends not only on the initiation of cell cycle checkpoints but also on checkpoint maintenance.
Marcel A T M van Vugt, Alexandra K Gardino, Rune Linding, Gerard J Ostheimer, H Christian Reinhardt, Shao-En Ong, Chris S Tan, Hua Miao, Susan M Keezer, Jeijin Li, Tony Pawson, Timothy A Lewis, Steven A Carr, Stephen J Smerdon, Thijn R Brummelkamp, Michael B Yaffe   +15 more
doaj   +1 more source

Checkpoint inhibition of origin firing prevents inappropriate replication outside of S-phase

eLife, 2021
Checkpoints maintain the order of cell cycle events during DNA damage or incomplete replication. How the checkpoint response is tailored to different phases of the cell cycle remains poorly understood.
Mark C Johnson, Geylani Can, Miguel Monteiro Santos, Diana Alexander, Philip Zegerman   +4 more
doaj   +1 more source

Dysregulated G2 phase checkpoint recovery pathway reduces DNA repair efficiency and increases chromosomal instability in a wide range of tumours

Oncogenesis, 2021
Defective DNA repair is being demonstrated to be a useful target in cancer treatment. Currently, defective repair is identified by specific gene mutations, however defective repair is a common feature of cancers without these mutations.
Madushan Fernando, Pascal H. G. Duijf, Martina Proctor, Alexander J. Stevenson, Anna Ehmann, Shivam Vora, Dubravka Skalamera, Mark Adams, Brian Gabrielli   +8 more
doaj   +1 more source

Characterization of nucleolar SUMO isopeptidases unveils a general p53-independent checkpoint of impaired ribosome biogenesis

Nature Communications, 2023
Ribosome biogenesis is a multi-step process, in which a network of trans-acting factors ensures the coordinated assembly of pre-ribosomal particles in order to generate functional ribosomes.
Judith Dönig, Hannah Mende, Jimena Davila Gallesio, Kristina Wagner, Paul Hotz, Kathrin Schunck, Tanja Piller, Soraya Hölper, Sara Uhan, Manuel Kaulich, Matthias Wirth, Ulrich Keller, Georg Tascher, Katherine E. Bohnsack, Stefan Müller   +14 more
doaj   +1 more source

Crosstalk between Plk1, p53, cell cycle, and G2/M DNA damage checkpoint regulation in cancer: computational modeling and analysis

npj Systems Biology and Applications, 2021
Different cancer cell lines can have varying responses to the same perturbations or stressful conditions. Cancer cells that have DNA damage checkpoint-related mutations are often more sensitive to gene perturbations including altered Plk1 and p53 ...
Yongwoon Jung, Pavel Kraikivski, Sajad Shafiekhani, Scott S. Terhune, Ranjan K. Dash   +4 more
doaj   +1 more source

Direct monitoring of the strand passage reaction of DNA topoisomerase II triggers checkpoint activation. [PDF]

PLoS Genetics, 2013
By necessity, the ancient activity of type II topoisomerases co-evolved with the double-helical structure of DNA, at least in organisms with circular genomes.
Katherine L Furniss, Hung-Ji Tsai, Jo Ann W Byl, Andrew B Lane, Amit C Vas, Wei-Shan Hsu, Neil Osheroff, Duncan J Clarke   +7 more
doaj   +1 more source

Cell size checkpoint control by the retinoblastoma tumor suppressor pathway. [PDF]

PLoS Genetics, 2006
Size control is essential for all proliferating cells, and is thought to be regulated by checkpoints that couple cell size to cell cycle progression.
Su-Chiung Fang, Chris de los Reyes, James G Umen   +2 more
doaj   +1 more source