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Cell Cycle Checkpoint Kinase and Drug Resistance of Lung Cancer [PDF]
Chinese Journal of Lung Cancer, 2021 Lung cancer is the most commonly diagnosed cancer and the leading cause of cancer death. Although great progress has been made in chemotherapy, radiotherapy and targeted therapy, the emergence of acquired drug resistance hinders the efficacy of clinical ...
Zhiyin KE, Ailing LIANG, Yongjun LIU
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The cell cycle checkpoint inhibitors in the treatment of leukemias [PDF]
Journal of Hematology & Oncology, 2017 The inhibition of the DNA damage response (DDR) pathway in the treatment of cancers has recently reached an exciting stage with several cell cycle checkpoint inhibitors that are now being tested in several clinical trials in cancer patients. Although the
A. Ghelli Luserna di Rora’ +2 more
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Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency [PDF]
Nat Commun, 2020 A number of point mutations have been identified in reprogrammed pluripotent stem cells such as iPSCs and ntESCs. The molecular basis for these mutations has remained elusive however, which is a considerable impediment to their potential medical ...
R. Araki +12 more
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Cdk2 strengthens the intra-S checkpoint and counteracts cell cycle exit induced by DNA damage [PDF]
Scientific Reports, 2017 Although cyclin-dependent kinase 2 (Cdk2) controls the G1/S transition and promotes DNA replication, it is dispensable for cell cycle progression due to redundancy with Cdk1.
Katarina Bačević +5 more
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Expanding roles of cell cycle checkpoint inhibitors in radiation oncology [PDF]
International Journal of Radiation Biology, 2021 Purpose Radiation-induced activation of cell cycle checkpoints have been of long-standing interest. The WEE1, CHK1 and ATR kinases are key factors in cell cycle checkpoint regulation and are essential for the S and G2 checkpoints.
Sissel Hauge +5 more
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Acetylation of MORC2 by NAT10 regulates cell-cycle checkpoint control and resistance to DNA-damaging chemotherapy and radiotherapy in breast cancer [PDF]
Nucleic Acids Res, 2020 MORC family CW-type zinc finger 2 (MORC2) is an oncogenic chromatin-remodeling enzyme with an emerging role in DNA repair. Here, we report a novel function for MORC2 in cell-cycle checkpoint control through an acetylation-dependent mechanism.
Hong-Yi Liu +7 more
semanticscholar +2 more sources
OncoImmunology, 2018 Intrinsic resistance to cytotoxic T-lymphocyte (CTL) killing limits responses to immune activating anti-cancer therapies. Here, we established that activation of the G2/M cell cycle checkpoint results in tumor cell cycle pause and protection from ...
Lillian Sun +9 more
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Definitions, 2006 Cell growth and division proceeds through an ordered set of events called cell cycle, which is divided into four distinct phases namely G1 (the first gap phase), S (DNA synthesis), G2 (the second gap phase), and M (mitosis).
Wenjian Ma
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EBioMedicine, 2014 The identification of SYK as a molecular target in B-lineage leukemia/lymphoma cells prompted the development of SYK inhibitors as a new class of anti-cancer drug candidates.
Fatih M. Uckun +5 more
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TOP2A inhibition and its cellular effects related to cell cycle checkpoint adaptation pathway [PDF]
Scientific ReportsIn this study, we investigate the G2 checkpoint activated by chromosome entanglements, the so-called Decatenation Checkpoint (DC), which can be activated by TOP2A catalytic inhibition.
Maria Arroyo +5 more
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