eLife, 2023 A growing body of evidence suggests that cell division and basement membrane invasion are mutually exclusive cellular behaviors. How cells switch between proliferative and invasive states is not well understood.
Taylor N Medwig-Kinney +12 more
doaj +1 more source
Serine/Threonine Kinase Unc-51-like Kinase-1 (Ulk1) Phosphorylates the Co-chaperone Cell Division Cycle Protein 37 (Cdc37) and Thereby Disrupts the Stability of Cdc37 Client Proteins [PDF]
Journal of Biological Chemistry, 2017 The serine/threonine kinase Unc-51-like kinase-1 (Ulk1) is thought to be essential for induction of autophagy, an intracellular bulk degradation process that is activated by various stresses. Although several proteins have been suggested as Ulk1 substrates during autophagic process, it still remains largely unknown about Ulk1's physiological substrates.
Ran, Li +10 more
openaire +2 more sources
Identification of crucial genes based on expression profiles of hepatocellular carcinomas by bioinformatics analysis [PDF]
PeerJ, 2019 Hepatocellular carcinoma (HCC) is one of the most heterogeneous malignant cancers with no effective targets and treatments. However, the molecular pathogenesis of HCC remains largely uncertain. The aims of our study were to find crucial genes involved in
Ze-Kun Liu +6 more
doaj +2 more sources
A global view of substrate phosphorylation and dephosphorylation during budding yeast mitotic exit
Microbial Cell, 2018 The cell cycle is the process by which a cell duplicates its DNA during S-phase and divides its chromosomes during M-phase, creating two genetically identical daughter cells.
Sandra A. Touati, Frank Uhlmann
doaj +1 more source
Cell Death Discovery, 2022 Sorafenib is a classical targeted drug for the treatment of advanced hepatocellular carcinoma (HCC), but intrinsic resistance severely limited its therapeutic effects.
Li Li +5 more
doaj +1 more source
Frontiers in Oncology, 2022 ObjectiveUterine leiomyosarcoma (ULMS) is the most common subtype of uterine sarcoma and is difficult to discern from uterine leiomyoma (ULM) preoperatively.
Yumin Ke +5 more
doaj +1 more source
In silico analysis of the HSP90 chaperone system from the African trypanosome, Trypanosoma brucei
Frontiers in Molecular Biosciences, 2022 African trypanosomiasis is a neglected tropical disease caused by Trypanosoma brucei (T. brucei) and spread by the tsetse fly in sub-Saharan Africa. The trypanosome relies on heat shock proteins for survival in the insect vector and mammalian host.
Miebaka Jamabo +5 more
doaj +1 more source
Influence of cell cycle phase on calcification in the coccolithophore Emiliania huxleyi [PDF]
, 2008 Calcification of the cosmopolitan coccolithophore species Emiliania huxleyi was investigated in relation to the cell division cycle with the use of batch cultures.
Antia, Avan +2 more
core +1 more source
L-arginine and N-carbamoylglutamic acid supplementation enhance young rabbit growth and immunity by regulating intestinal microbial community [PDF]
Asian-Australasian Journal of Animal Sciences, 2020 Objective An experiment was conducted to determine the effects of L-arginine (L-Arg) and N-carbamoylglutamic acid (NCG) on the growth, metabolism, immunity and community of cecal bacterial flora of weanling and young rabbits.
Xiaoming Sun +10 more
doaj +1 more source
Evidence for an interplay between cell cycle progression and the initiation of differentiation between life cycle forms of African trypanosomes [PDF]
, 1994 Successful transmission of the African trypanosome between the mammalian host blood-stream and the tsetse fly vector involves dramatic alterations in the parasite's morphology and biochemistry.
Gull, K, Matthews, K R
core +1 more source