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A Novel 2.5D Culture Platform to Investigate the Role of Stiffness Gradients on Adhesion-Independent Cell Migration [PDF]
, 2014 Current studies investigating the role of biophysical cues on cell migration focus on the use of culture platforms with static material parameters. However, migrating cells in vivo often encounter spatial variations in extracellular matrix stiffness.
Asuri, Prashanth +2 more
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Invadopodia, a Kingdom of Non-Receptor Tyrosine Kinases
Cells, 2021 Non-receptor tyrosine kinases (NRTKs) are crucial mediators of intracellular signaling and control a wide variety of processes such as cell division, morphogenesis, and motility.
Trishna Saha, Hava Gil-Henn
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Intermediate Filaments from Tissue Integrity to Single Molecule Mechanics
Cells, 2021 Cytoplasmic intermediate filaments (IFs), which together with actin and microtubules form the cytoskeleton, are composed of a large and diverse family of proteins.
Emma J. van Bodegraven +1 more
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Are We Ready for Migrastatics?
Cells, 2021 Metastasis accounts for the highest mortality rates in solid tumor cancer patients. However, research and development have neglected this most lethal characteristic and, instead, have concentrated on the hallmarks of cancer that make tumor cells highly ...
Jonathan Solomon +4 more
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PTEN inhibits AMPK to control collective migration
Nature Communications, 2022 Pten is a tumour suppressor gene that is associated with highly invasive cancers such as glioblastoma. Here the authors show that PTEN loss results in increased migratory behaviour, which can be countered by targeting AMPK activity.
Florent Peglion +9 more
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Pannexin Channel Regulation of Cell Migration: Focus on Immune Cells
Frontiers in Immunology, 2021 The role of Pannexin (PANX) channels during collective and single cell migration is increasingly recognized. Amongst many functions that are relevant to cell migration, here we focus on the role of PANX-mediated adenine nucleotide release and associated ...
Paloma A. Harcha +3 more
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Frontiers in Cell and Developmental Biology, 2021 The origin of multicellular life from unicellular beings is an epochal step in the evolution of eukaryotes. There are several factors influencing cell fate choices during differentiation and morphogenesis of an organism. Genetic make-up of two cells that
Ranjani Dhakshinamoorthy +1 more
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Frontiers in Microbiology, 2022 The C-terminus of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) protein E contains a PBM (PDZ-binding motif) targeting PDZ (PSD-95/Dlg/ZO-1) domains, which is identical to the PBM of SARS-CoV.
Yanlei Zhu +9 more
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eLife, 2021 Physiological and pathological morphogenetic events involve a wide array of collective movements, suggesting that multicellular arrangements confer biochemical and biomechanical properties contributing to tissue-scale organization.
Yelena Y Bernadskaya +4 more
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Regulation of P53 signaling in breast cancer by the E3 ubiquitin ligase RNF187
Cell Death and Disease, 2022 The tumor suppressor P53 plays critical role in preventing cancer. P53 is rarely mutated and remains functional in luminal-type breast cancer(1).
Xin Li +13 more
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