Results 81 to 90 of about 1,443,234 (190)

Rapid autofluorescence flow cytometric analysis of agonist-induced neutrophil and eosinophil polarization reveals novel insights into 5-oxo-ETE-mediated granulocyte activation

Journal of Inflammation
Minimizing unintended granulocyte activation while measuring functional responsiveness is essential, as the use of external probes, antibodies, or fluorescent dyes can potentially alter cellular responsiveness.
Anuruddika J. Fernando, Fiona Rossi, Destiny Docherty, Anna Popravko, Lucy Masters, Boydd Houston, Renu Gupta, Kevin Dhaliwal, Adriano G. Rossi   +8 more
doaj   +1 more source

Renormalization of radiobiological response functions by energy loss fluctuations and complexities in chromosome aberration induction: deactivation theory for proton therapy from cells to tumor control

, 2019
We employ a multi-scale mechanistic approach to investigate radiation induced cell toxicities and deactivation mechanisms as a function of linear energy transfer in hadron therapy.
Abolfath, Ramin, Bronk, Lawrence, Carabe, Alejandro, Grosshans, David, Helo, Yusuf, Mohan, Radhe   +5 more
core   +1 more source

Signalling cell cycle arrest and cell death through the MMR System [PDF]

, 2006
Loss of DNA mismatch repair (MMR) in mammalian cells, as well as having a causative role in cancer, has been linked to resistance to certain DNA damaging agents including clinically important cytotoxic chemotherapeutics.
Brown, R., O'Brien, V.
core   +1 more source

Proteomic analysis of aged microglia: shifts in transcription, bioenergetics, and nutrient response

Journal of Neuroinflammation, 2017
Background Age is the primary risk factor for many diseases. As such, age is a critical co-factor for examination in order to understand the progression and potential intervention in disease progression.
Antwoine Flowers, Harris Bell-Temin, Ahmad Jalloh, Stanley M. Stevens, Paula C. Bickford   +4 more
doaj   +1 more source

Efficacy of different preoperative antiseptics in preventing a risk of surgical site infections: a systematic review and meta‑analysis of randomized controlled trials

Videosurgery and Other Miniinvasive Techniques
Introduction: Surgical site infection (SSI) is a predominant postoperative complication that markedly increases health care expenses. Published systematic reviews, meta-analyses and international guidelines vary in their recommendations for the most ...
Lutao Yang, Shunxin Liao, Qing Cao, Sanjay Rastogi   +3 more
doaj   +1 more source

In wound repair vimentin mediates the transition of mesenchymal leader cells to a myofibroblast phenotype. [PDF]

, 2018
Following injury, mesenchymal repair cells are activated to function as leader cells that modulate wound healing. These cells have the potential to differentiate to myofibroblasts, resulting in fibrosis and scarring.
Alnwibit, A. A., Bleaken, B. M., Menko, A. S., Romisher, A. R., Walker, J. L.   +4 more
core   +1 more source

Evolutionary dynamics of adult stem cells: Comparison of random and immortal strand segregation mechanisms

, 2004
This paper develops a point-mutation model describing the evolutionary dynamics of a population of adult stem cells. Such a model may prove useful for quantitative studies of tissue aging and the emergence of cancer.
A. T. Natarajan, C. S. Potten, D. Voet, J. R. Merok, T. Helleday   +4 more
core   +1 more source

Compensatory metabolic networks in pancreatic cancers upon perturbation of glutamine metabolism

Nature Communications, 2017
Glutaminase inhibition (GLSi) has promising activity against certain cancers. Here, the authors show that GLSi has no effect on multiple mouse models of pancreatic cancer and characterize the metabolic pathways activated in response to GLSi whose ...
Douglas E. Biancur, Joao A. Paulo, Beata Małachowska, Maria Quiles Del Rey, Cristovão M. Sousa, Xiaoxu Wang, Albert S. W. Sohn, Gerald C. Chu, Steven P. Gygi, J. Wade Harper, Wojciech Fendler, Joseph D. Mancias, Alec C. Kimmelman   +12 more
doaj   +1 more source

Irf6 directs glandular lineage differentiation of epidermal progenitors and promotes limited sweat gland regeneration in a mouse burn model

Stem Cell Research & Therapy, 2018
Background Damaged or malfunctioning sweat glands (SGs) after a burn injury would cause significant hyperthermia and even death, and there is an unmet need for effective treatment.
Bin Yao, Wei Song, Zhao Li, Tian Hu, Rui Wang, Yihui Wang, Sha Huang, Xiaobing Fu   +7 more
doaj   +1 more source

The Treatment of Neurodegenerative Disorders Using Umbilical Cord Blood and Menstrual Blood-Derived Stem Cells

Cell Transplantation, 2011
Stem cell transplantation is a potentially important means of treatment for a number of disorders. Two different stem cell populations of interest are mononuclear umbilical cord blood cells and menstrual blood-derived stem cells.
Paul R. Sanberg, David J. Eve, Alison E. Willing, Svitlana Garbuzova-Davis, Jun Tan, Cyndy D. Sanberg, Julie G. Allickson, L. Eduardo Cruz, Cesar V. Borlongan   +8 more
doaj   +1 more source