Results 11 to 20 of about 123,953 (269)
An Algorithm for Cellular Reprogramming [PDF]
Proceedings of the National Academy of Sciences, 2017 The day we understand the time evolution of subcellular elements at a level of detail comparable to physical systems governed by Newton's laws of motion seems far away. Even so, quantitative approaches to cellular dynamics add to our understanding of cell biology, providing data-guided frameworks that allow us to develop better predictions about and ...
Scott Ronquist +9 more
arxiv +8 more sources
Re: Epigenetics of Cellular Reprogramming [PDF]
Journal of Urological Surgery, 2016 EDITORIAL COMMENT Cells have some specific molecular and physiological properties that act their functional process. However, many cells have an ability of efficient transition from one type to another. This ability is named plasticity.
Fehmi Narter
doaj +2 more sources
Cellular reprogramming and epigenetic rejuvenation. [PDF]
Clin Epigenetics, 2021 AbstractAgeing is an inevitable condition that afflicts all humans. Recent achievements, such as the generation of induced pluripotent stem cells, have delivered preliminary evidence that slowing down and reversing the ageing process might be possible. However, these techniques usually involve complete dedifferentiation, i.e.
Simpson DJ, Olova NN, Chandra T.
europepmc +6 more sources
Epigenetics of cellular reprogramming [PDF]
Current Opinion in Genetics & Development, 2013 Cells are constantly changing their state of equilibrium in response to internal and external stimuli. These changes in cell identity are driven by highly coordinated modulation of gene expression. This coordinated regulation is achieved in large part due to changes in the structure and composition of the chromatin, driven by epigenetic modulators ...
Krishnakumar, Raga, Blelloch, Robert H
openaire +4 more sources
Transcriptional reprogramming in cellular quiescence [PDF]
RNA Biology, 2017 Most cells in nature are not actively dividing, yet are able to return to the cell cycle given the appropriate environmental signals. There is now ample evidence that quiescent G0 cells are not shut-down but still metabolically and transcriptionally active.
Roche, B. +2 more
openaire +6 more sources
Cellular Reprogramming in Pursuit of Immortality [PDF]
Cell Stem Cell, 2012 The discovery that phenotypic diversity among differentiated cells results from epigenetic and not genetic differences, and can be reset to restore pluripotency, promises revolutionary advances in medicine. I discuss how this and related seminal discoveries have brought us to an exciting future.
M. Azim Surani, M. Azim Surani
openaire +3 more sources
Cellular reprogramming in skin cancer [PDF]
Seminars in Cancer Biology, 2015 Early primitive stem cells have long been viewed as the cancer cells of origin (tumor initiating target cells) due to their intrinsic features of self-renewal and longevity. However, emerging evidence suggests a surprising capacity for normal committed cells to function as reserve stem cells upon reprogramming as a consequence of tissue damage ...
Song, Ihn Young, Balmain, Allan
openaire +4 more sources
Molecular Roadblocks for Cellular Reprogramming [PDF]
Molecular Cell, 2012 During development, diverse cellular identities are established and maintained in the embryo. Although remarkably robust in vivo, cellular identities can be manipulated using experimental techniques. Lineage reprogramming is an emerging field at the intersection of developmental and stem cell biology in which a somatic cell is stably reprogrammed into ...
Thomas Vierbuchen, Marius Wernig
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Cellular Reprogramming-A Model for Melanoma Cellular Plasticity. [PDF]
Int J Mol Sci, 2020 Cellular plasticity of cancer cells is often associated with phenotypic heterogeneity and drug resistance and thus remains a major challenge for the treatment of melanoma and other types of cancer. Melanoma cells have the capacity to switch their phenotype during tumor progression, from a proliferative and differentiated phenotype to a more invasive ...
Granados K +3 more
europepmc +5 more sources
DNA methylation and cellular reprogramming [PDF]
Trends in Cell Biology, 2010 The recent discovery that a small number of defined factors are sufficient to reprogram somatic cells into pluripotent stem cells has significantly expanded our knowledge of the plasticity of the epigenome. In this review we discuss some aspects of cell fate plasticity and epigenetic alterations, with emphasis on DNA methylation during cellular ...
Peter A. Jones +2 more
openaire +3 more sources