Results 21 to 30 of about 224,348 (348)

TFcomb identifies transcription factor combinations for cellular reprogramming based on single-cell multiomics data. [PDF]

Genome Res
Li C, Chen S, Chen Y, Bian H, Hao M, Wei L, Zhang X.   +6 more
europepmc   +3 more sources

Cellular internalization effect of Ara27 in various cell lines

Journal of Animal Reproduction and Biotechnology, 2022
Protein and peptide candidates are screened to apply therapeutic application as a drug. Ensuring that these candidates are delivered and maximized effectiveness is still challenging and a variety of studies are ongoing.
Minseo Kim, Sangkyu Park, Jeongmin Seo, Sangho Roh   +3 more
doaj   +1 more source

Human Neural Stem Cells for Cell-Based Medicinal Products

Cells, 2021
Neural stem cells represent an attractive tool for the development of regenerative therapies and are being tested in clinical trials for several neurological disorders.
Beatriz Fernandez-Muñoz, Ana Belen Garcia-Delgado, Blanca Arribas-Arribas, Rosario Sanchez-Pernaute   +3 more
doaj   +1 more source

Epigenetics of cellular reprogramming [PDF]

Current Opinion in Genetics & Development, 2013
Cells are constantly changing their state of equilibrium in response to internal and external stimuli. These changes in cell identity are driven by highly coordinated modulation of gene expression. This coordinated regulation is achieved in large part due to changes in the structure and composition of the chromatin, driven by epigenetic modulators ...
Krishnakumar, Raga, Blelloch, Robert H
openaire   +4 more sources

Exopolysaccharide of Enterococcus faecium L15 promotes the osteogenic differentiation of human dental pulp stem cells via p38 MAPK pathway

Stem Cell Research & Therapy, 2022
Background Bone has important functions in the body. Several researchers have reported that the polysaccharides and lipopolysaccharide derived from microbes can promote osteogenic differentiation of stem cells.
Hyewon Kim, Naeun Oh, Mijin Kwon, Oh-Hee Kwon, Seockmo Ku, Jeongmin Seo, Sangho Roh   +6 more
doaj   +1 more source

High Therapeutic and Esthetic Properties of Extracellular Vesicles Produced from the Stem Cells and Their Spheroids Cultured from Ocular Surgery-Derived Waste Orbicularis Oculi Muscle Tissues

Antioxidants, 2021
Extracellular vesicles (EVs) are paracrine factors that mediate stem cell therapeutics. We aimed at evaluating the possible therapeutic and esthetic applications of EVs prepared from the waste human facial tissue-derived orbicularis oculi muscle stem ...
Kyung Min Lim, Ahmed Abdal Dayem, Yujin Choi, Yoonjoo Lee, Jongyub An, Minchan Gil, Soobin Lee, Hee Jeong Kwak, Balachandar Vellingirl, Hyun Jin Shin, Ssang-Goo Cho   +10 more
doaj   +1 more source

DNA methylation and cellular reprogramming [PDF]

Trends in Cell Biology, 2010
The recent discovery that a small number of defined factors are sufficient to reprogram somatic cells into pluripotent stem cells has significantly expanded our knowledge of the plasticity of the epigenome. In this review we discuss some aspects of cell fate plasticity and epigenetic alterations, with emphasis on DNA methylation during cellular ...
Daniel D, De Carvalho, Jueng Soo, You, Peter A, Jones   +2 more
openaire   +2 more sources

Enhanced chromatin accessibility contributes to X chromosome dosage compensation in mammals

Genome Biology, 2021
Background Precise gene dosage of the X chromosomes is critical for normal development and cellular function. In mice, XX female somatic cells show transcriptional X chromosome upregulation of their single active X chromosome, while the other X ...
Irene Talon, Adrian Janiszewski, Bart Theeuwes, Thomas Lefevre, Juan Song, Greet Bervoets, Lotte Vanheer, Natalie De Geest, Suresh Poovathingal, Ryan Allsop, Jean-Christophe Marine, Florian Rambow, Thierry Voet, Vincent Pasque   +13 more
doaj   +1 more source

A Rho Kinase (ROCK) Inhibitor, Y-27632, Inhibits the Dissociation-Induced Cell Death of Salivary Gland Stem Cells

Molecules, 2021
Salivary gland stem cells (SGSCs) are potential cell sources for the treatment of salivary gland diseases. The control of cell survival is an essential factor for applying stem cells to regenerative medicine or stem cell-based research.
Kichul Kim, Sol Min, Daehwan Kim, Hyewon Kim, Sangho Roh   +4 more
doaj   +1 more source

Cellular reprogramming in skin cancer [PDF]

Seminars in Cancer Biology, 2015
Early primitive stem cells have long been viewed as the cancer cells of origin (tumor initiating target cells) due to their intrinsic features of self-renewal and longevity. However, emerging evidence suggests a surprising capacity for normal committed cells to function as reserve stem cells upon reprogramming as a consequence of tissue damage ...
Song, Ihn Young, Balmain, Allan
openaire   +4 more sources