Results 31 to 40 of about 123,953 (269)
Reprogramming cellular identity in vivo [PDF]
Development, 2022 ABSTRACT Cellular identity is established through complex layers of genetic regulation, forged over a developmental lifetime. An expanding molecular toolbox is allowing us to manipulate these gene regulatory networks in specific cell types in vivo.
Sydney Leaman +2 more
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Journal of Animal Reproduction and Biotechnology, 2018 Hedgehog (Hh) pathway plays a key role in development from invertebrate to vertebrate. It is known to be involved in cell differentiation, polarity, proliferation, including the development of vertebrate limb and the establishment of flies’ body plan. To
Jaehyun Park +4 more
doaj +1 more source
Epigenetic landscapes explain partially reprogrammed cells and identify key reprogramming genes [PDF]
Lang AH, Li H, Collins JJ, Mehta P (2014) Epigenetic Landscapes
Explain Partially Reprogrammed Cells and Identify Key Reprogramming Genes.
PLoS Comput Biol 10(8): e1003734. doi:10.1371/journal.pcbi.1003734, 2012 A common metaphor for describing development is a rugged "epigenetic landscape" where cell fates are represented as attracting valleys resulting from a complex regulatory network. Here, we introduce a framework for explicitly constructing epigenetic landscapes that combines genomic data with techniques from spin-glass physics.
arxiv +1 more source
Physiological cellular reprogramming and cancer
Seminars in Cancer Biology, 2010 The traditional approaches to cancer research and therapy have been primarily focused in the aspect of aberrant, uncontrolled, proliferation. Although this is clearly a very important issue, however, the emphasis on this characteristic has led to a relative neglect of an essential aspect of cancer biology: the alteration of normal differentiation ...
César Cobaleda +3 more
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Cellular reprogramming for clinical cartilage repair [PDF]
Cell Biology and Toxicology, 2017 The repair of articular cartilage needs a sufficient number of chondrocytes to replace the defect tissue, and therefore, expansion of cells is generally required. Chondrocytes derived by cellular reprogramming may provide a solution to the limitations of current (stem) cell-based therapies.
Driessen, B.J.H., Logie, C., Vonk, L.A.
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Molecular versatility during pluripotency progression
Nature Communications, 2023 During development the embryo must balance lineage specification against the preservation of plasticity using a limited molecular toolkit. In this Perspective, the authors propose Molecular Versatility as a paradigm for grouping molecular mechanisms that
Giacomo Furlan +3 more
doaj +1 more source
Cell reprogramming modelled as transitions in a hierarchy of cell cycles [PDF]
J. Phys. A: Math. Theor. 50 (2017) 425601 (23pp), 2016 We construct a model of cell reprogramming (the conversion of fully differentiated cells to a state of pluripotency, known as induced pluripotent stem cells, or iPSCs) which builds on key elements of cell biology viz. cell cycles and cell lineages. Although reprogramming has been demonstrated experimentally, much of the underlying processes governing ...
arxiv +1 more source
The basal level of gene expression associated with chromatin loosening shapes Waddington landscapes and controls cell differentiation [PDF]
J. Mol. Biol. 432 (2020) 2253-2270, 2020 The baseline level of transcription, which is variable and difficult to quantify, seriously complicates the normalization of comparative transcriptomic data, but its biological importance remains unappreciated. We show that this currently neglected ingredient is essential for controlling gene network multistability and therefore cellular ...
arxiv +1 more source
Dynamical-systems theory of cellular reprogramming [PDF]
arXiv, 2021 In cellular reprogramming, almost all epigenetic memories of differentiated cells are erased by the overexpression of few genes, regaining pluripotency, potentiality for differentiation. Considering the interplay between oscillatory gene expression and slower epigenetic modifications, such reprogramming is perceived as an unintuitive, global attraction
arxiv
Implications of Cellular Aging in Cardiac Reprogramming [PDF]
Frontiers in Cardiovascular Medicine, 2018 Aging is characterized by a chronic functional decline of organ systems which leads to tissue dysfunction over time, representing a risk factor for diseases development, including cardiovascular. The aging process occurring in the cardiovascular system involves heart and vessels at molecular and cellular level, with subsequent structural modifications ...
Fabiana Passaro +2 more
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