Results 31 to 40 of about 224,348 (348)
Transcriptional reprogramming in cellular quiescence [PDF]
RNA Biology, 2017 Most cells in nature are not actively dividing, yet are able to return to the cell cycle given the appropriate environmental signals. There is now ample evidence that quiescent G0 cells are not shut-down but still metabolically and transcriptionally active.
Roche, Benjamin +2 more
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Molecules, 2020 Human malignant melanoma is the most aggressive type of skin cancer with high metastatic ability. Despite several traditional therapies, the mortality rate remains high. Lactobacillus plantarum (L.
Jaehyun Park +5 more
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Cold Spring Harbor Perspectives in Biology, 2014 Nuclear reprogramming technology was first established more than 50 years ago. It can rejuvenate somatic cells by erasing the epigenetic memories and reconstructing a new pluripotent order. The recent discovery reviewed here that induced pluripotency can be achieved by a small set of transcription factors has opened up unprecedented opportunities in ...
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Molecular Roadblocks for Cellular Reprogramming [PDF]
Molecular Cell, 2012 During development, diverse cellular identities are established and maintained in the embryo. Although remarkably robust in vivo, cellular identities can be manipulated using experimental techniques. Lineage reprogramming is an emerging field at the intersection of developmental and stem cell biology in which a somatic cell is stably reprogrammed into ...
Vierbuchen, Thomas, Wernig, Marius
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Journal of Translational Medicine, 2023 Background The incidence of bladder cancer (BCa) is approximately four times higher in men than in women. To develop effective BCa treatments, there is an urgent need to understand the differences in the BCa control mechanisms based on gender. Our recent
Jaekwon Seok +6 more
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Pluripotent Stem Cells for Spinal Cord Injury Repair
Cells, 2021 Spinal cord injury (SCI) is a devastating condition of the central nervous system that strongly reduces the patient’s quality of life and has large financial costs for the healthcare system.
Maria Martin-Lopez +2 more
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Cellular Reprogramming—A Model for Melanoma Cellular Plasticity [PDF]
International Journal of Molecular Sciences, 2020 Cellular plasticity of cancer cells is often associated with phenotypic heterogeneity and drug resistance and thus remains a major challenge for the treatment of melanoma and other types of cancer. Melanoma cells have the capacity to switch their phenotype during tumor progression, from a proliferative and differentiated phenotype to a more invasive ...
Karol Granados +3 more
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Human Amniocytes Are Receptive to Chemically Induced Reprogramming to Pluripotency [PDF]
, 2017 Restoring pluripotency using chemical compounds alone would be a major step forward in developing clinical-grade pluripotent stem cells, but this has not yet been reported in human cells.
Adjaye, J +15 more
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The Journal of Reproduction and Development, 2019 Historically, it had been widely accepted that the female mammalian ovary contained a limited number of oocytes that would reduce over time, without the possibility of replenishment. However, recent studies have suggested that female germline stem cells (
Huy-Hoang NGUYEN +4 more
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Stem Cell Research, 2022 Charcot-Marie-Tooth type 4B3 (CMT4B3) is a rare subtype of hereditary neuropathy associated with variants in the MTMR5/SBF1 gene. Herein, we report the generation and characterization of a hiPSC line from a 12-year-old Italian girl with early onset ...
Elisa Maria Turco +12 more
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