Results 41 to 50 of about 123,953 (269)
Journal of Animal Reproduction and Biotechnology, 2018 Polo-like kinase 1 (Plk1) has been known to be a critical element in cell division including centrosome maturation, cytokinesis and spindle formation in somatic, cancer, and mammalian embryonic cells.
Jeonghyeon Moon, Sangho Roh
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The Journal of Reproduction and DevelopmentIn vitro production of porcine-hatched blastocysts is important for various applications. However, the mechanobiology of blastocoel expansion and hatching remains poorly understood.
Ba Anh My LE +6 more
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Global Epigenetic State Network Governs Cellular Pluripotent Reprogramming and Transdifferentiation [PDF]
Interface Focus 4(3):20130068 (2014), 2012 How do mammalian cells that share the same genome exist in notably distinct phenotypes, exhibiting differences in morphology, gene expression patterns, and epigenetic chromatin statuses? Furthermore how do cells of different phenotypes differentiate reproducibly from a single fertilized egg?
arxiv +1 more source
Direct cellular reprogramming: the hopes and the hurdles [PDF]
European Journal of Heart Failure, 2016 Comment on Direct cellular reprogramming for cardiac repair and regeneration.
SINAGRA, GIANFRANCO, FABRIS, ENRICO
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Diagnostics, 2022 Alzheimer’s disease (AD) is neurodegeneration that accounts for 60–70% of dementia cases. Symptoms begin with mild memory difficulties and evolve towards cognitive impairment.
Maria-del-Carmen Silva-Lucero +8 more
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Cellular Reprogramming toward the Erythroid Lineage [PDF]
International Journal of Cell Biology, 2011 Haemoglobinopathies such as thalassaemia and sickle cell disease present a major health burden. Currently, the main forms of treatment for these diseases are packed red blood cell transfusions and the administration of drugs which act to nonspecifically reactivate the production of foetal haemoglobin. These treatments are ongoing throughout the life of
Merlin Crossley +3 more
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Chromatin Connections to Pluripotency and Cellular Reprogramming [PDF]
Cell, 2011 The pluripotent state of embryonic stem cells (ESCs) provides a unique perspective on regulatory programs that govern self-renewal and differentiation and somatic cell reprogramming. Here, we review the highly connected protein and transcriptional networks that maintain pluripotency and how they are intertwined with factors that affect chromatin ...
Konrad Hochedlinger +2 more
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The Importance of Ubiquitination and Deubiquitination in Cellular Reprogramming [PDF]
Stem Cells International, 2016 Ubiquitination of core stem cell transcription factors can directly affect stem cell maintenance and differentiation. Ubiquitination and deubiquitination must occur in a timely and well‐coordinated manner to regulate the protein turnover of several stemness related proteins, resulting in optimal embryonic stem cell maintenance and differentiation ...
Suresh Ramakrishna +3 more
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New Insights into X-Chromosome Reactivation during Reprogramming to Pluripotency
Cells, 2020 Dosage compensation between the sexes results in one X chromosome being inactivated during female mammalian development. Chromosome-wide transcriptional silencing from the inactive X chromosome (Xi) in mammalian cells is erased in a process termed X ...
Amitesh Panda +2 more
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International Journal of Hyperthermia, 2023 Cellular metabolic reprogramming is an important feature of malignant tumors. Metabolic reprogramming causes changes in the levels or types of specific metabolites inside and outside the cell, which affects tumorigenesis and progression by influencing ...
Yuchuan Yang +3 more
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