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Cellular senescence and polycystic ovary syndrome: mechanisms and therapeutic strategies from a new perspective [PDF]

Annals of Medicine
Objective Cellular senescence is often linked to diseases or states of dysfunction, including reproductive disorders caused by ovarian dysfunction. It plays a significant role in conditions like polycystic ovary syndrome (PCOS).
Xin Xin, Li Dong, Jiaxi Li, Jinfu Zhang, Haicui Wu   +4 more
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Hallmarks of cellular senescence: biology, mechanisms, regulations [PDF]

Experimental and Molecular Medicine
Cellular senescence is a process in which the cell cycle becomes permanently arrested, thereby inhibiting cell division, proliferation and growth. Various cellular stresses, such as DNA damage, telomere shortening and oxidative stress, can trigger ...
Amir Ajoolabady, Domenico Pratico, Suhad Bahijri, Jaakko Tuomilehto, Vladimir N. Uversky, Jun Ren   +5 more
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Pericentromeric repetitive ncRNA regulates chromatin interaction and inflammatory gene expression

Nucleus, 2022
Cellular senescence provokes a dramatic alteration of chromatin organization and gene expression profile of proinflammatory factors, thereby contributing to various age-related pathologies via the senescence-associated secretory phenotype (SASP ...
Kenichi Miyata, Akiko Takahashi
doaj   +1 more source

Telomere Maintenance and the cGAS-STING Pathway in Cancer

Cells, 2022
Cancer cells exhibit the unique characteristics of high proliferation and aberrant DNA damage response, which prevents cancer therapy from effectively eliminating them.
Hiroshi Ebata, Tze Mun Loo, Akiko Takahashi   +2 more
doaj   +1 more source

Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells

Nature Communications, 2022
Ras mutations induce cell competition and cellular senescence to inhibit the proliferation of oncogenic mutated cells. Here the authors demonstrate that cellular senescence inhibits cell competition-induced elimination of oncogenic cells through HGF ...
Nanase Igarashi, Kenichi Miyata, Tze Mun Loo, Masatomo Chiba, Aki Hanyu, Mika Nishio, Hiroko Kawasaki, Hao Zheng, Shinya Toyokuni, Shunsuke Kon, Keiji Moriyama, Yasuyuki Fujita, Akiko Takahashi   +12 more
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The use of the soluble receptor for advanced glycation-end products (sRAGE) as a potential biomarker of disease risk and adverse outcomes

Redox Biology, 2021
The soluble receptor for advanced glycation end-products (sRAGE) has been classically considered a sink for pro-inflammatory RAGE ligands and as such has been associated with protection from inflammatory stress and disease.
Jorge D. Erusalimsky
doaj   +1 more source

RNaseH2A downregulation drives inflammatory gene expression via genomic DNA fragmentation in senescent and cancer cells

Communications Biology, 2022
Cellular senescence caused by oncogenic stimuli is associated with the development of various age-related pathologies through the senescence-associated secretory phenotype (SASP).
Sho Sugawara, Ryo Okada, Tze Mun Loo, Hisamichi Tanaka, Kenichi Miyata, Masatomo Chiba, Hiroko Kawasaki, Kaoru Katoh, Shizuo Kaji, Yoshiro Maezawa, Koutaro Yokote, Mizuho Nakayama, Masanobu Oshima, Koji Nagao, Chikashi Obuse, Satoshi Nagayama, Keiyo Takubo, Akira Nakanishi, Masato T. Kanemaki, Eiji Hara, Akiko Takahashi   +20 more
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Cellular senescence in asthma: from pathogenesis to therapeutic challenges

EBioMedicine, 2023
Summary: Asthma is a heterogeneous chronic respiratory disease that impacts nearly 10% of the population worldwide. While cellular senescence is a normal physiological process, the accumulation of senescent cells is considered a trigger that transforms ...
Rongjun Wan, Prakhyath Srikaram, Vineeta Guntupalli, Chengping Hu, Qiong Chen, Peisong Gao   +5 more
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High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasone

Respiratory Research, 2022
Blood levels of the soluble receptor for advanced glycation end-products (sRAGE) are acutely elevated during the host inflammatory response to infection and predict mortality in COVID-19.
Lee Butcher, Jun-Cezar Zaldua, Jose A. Carnicero, Karl Hawkins, Janet Whitley, Rangaswamy Mothukuri, Phillip A. Evans, Keith Morris, Suresh Pillai, Jorge D. Erusalimsky   +9 more
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Genome wide CRISPR/Cas9 screen identifies the coagulation factor IX (F9) as a regulator of senescence

Cell Death and Disease, 2022
During this last decade, the development of prosenescence therapies has become an attractive strategy as cellular senescence acts as a barrier against tumour progression.
Paula Carpintero-Fernández, Michela Borghesan, Olga Eleftheriadou, Belen Pan-Castillo, Juan Antonio Fafián-Labora, Tom P. Mitchell, Alejandro Yuste, Muge Ogrunc, Thomas D. Nightingale, Maria Mayan, Ana O’Loghlen   +10 more
doaj   +1 more source