Results 1 to 10 of about 223,511 (134)

TRAF3 regulates homeostasis of CD8+ central memory T cells. [PDF]

PLoS ONE, 2014
Our laboratory reported previously that TNF receptor associated factor 3 (TRAF3) is a positive regulator of TCR signaling and T cell function. In the current study, we present new findings that reveal differential roles for TRAF3 in the regulation of CD4+
Zuoan Yi, Laura L Stunz, Wai Wai Lin, Gail A Bishop   +3 more
doaj   +5 more sources

CD4(+)CD62L(+) central memory T cells can be converted to Foxp3(+) T cells. [PDF]

PLoS ONE, 2013
The peripheral Foxp3(+) Treg pool consists of naturally arising Treg (nTreg) and adaptive Treg cells (iTreg). It is well known that naive CD4(+) T cells can be readily converted to Foxp3(+) iTreg in vitro, and memory CD4(+) T cells are resistant to ...
Xiaolong Zhang, Xian Chang Li, Xiang Xiao, Rui Sun, Zhigang Tian, Haiming Wei   +5 more
doaj   +6 more sources

Vaccination Expands Antigen-Specific CD4+ Memory T Cells and Mobilizes Bystander Central Memory T Cells. [PDF]

PLoS ONE, 2015
CD4+ T helper memory (Thmem) cells influence both natural and vaccine-boosted immunity, but mechanisms for their maintenance remain unclear. Pro-survival signals from the common gamma-chain cytokines, in particular IL-7, appear important.
Eleonora Li Causi, Suraj C Parikh, Lindsey Chudley, David M Layfield, Christian H Ottensmeier, Freda K Stevenson, Gianfranco Di Genova   +6 more
doaj   +7 more sources

Central memory T cells are the most effective precursors of resident memory T cells in human skin. [PDF]

Sci Immunol, 2022
The circulating precursor cells that give rise to human resident memory T cells (T RM ) are poorly characterized. We used an in vitro differentiation system and human skin–grafted mice to study T RM generation from circulating human memory T cell subsets. In vitro T RM
Matos TR, Gehad A, Teague JE, Dyring-Andersen B, Benezeder T, Dowlatshahi M, Crouch J, Watanabe Y, O'Malley JT, Kupper TS, Yang C, Watanabe R, Clark RA.   +12 more
europepmc   +4 more sources

T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells. [PDF]

PLoS ONE, 2013
Memory T cells are composed of effector, central, and memory stem cells. Previous studies have implicated that both T-bet and Eomes are involved in the generation of effector and central memory CD8 T cells.
Gang Li, Qianting Yang, Yibei Zhu, Hong-Rui Wang, Xinchun Chen, Xueguang Zhang, Binfeng Lu   +6 more
doaj   +5 more sources

ZAP-70 expression is associated with increased CD4 central memory T cells in chronic lymphocytic leukemia: cross-sectional study [PDF]

Hematology, Transfusion and Cell Therapy, 2018
Background: Although chronic lymphocytic leukemia is basically a B cell disease, its pathophysiology and evolution are thought to be significantly influenced by T cells, as these are probably the most important interaction partner of neoplastic B cells ...
Rodolfo Patussi Correia, Flávia Amoroso Matos e Silva, Nydia Strachman Bacal, Paulo Vidal Campregher, Nelson Hamerschlak, Gustavo Pessini Amarante-Mendes   +5 more
doaj   +2 more sources

Origins of CD4(+) effector and central memory T cells. [PDF]

Nat Immunol, 2011
Lineage-committed effector CD4(+) T cells are generated at the peak of the primary response and are followed by heterogeneous populations of central and effector memory cells. Here we review the evidence that T helper type 1 (T(H)1) effector cells survive the contraction phase of the primary response and become effector memory cells.
Pepper M, Jenkins MK.
europepmc   +4 more sources

Myelin-specific IL2 + T-cells are associated with last occurring relapse severity in relapsing–remitting multiple sclerosis [PDF]

Scientific Reports
Autoreactive T-cells against myelin are implicated in multiple sclerosis (MS) however, the functional relevance of IL2-producing central memory T-cells and IFNɣ-producing effector T-cells have not been assessed.
Rina Zilkha-Falb, Tali Drori, Katya Shwartz, Michael Gurevich   +3 more
doaj   +2 more sources

Selected microRNAs define cell fate determination of murine central memory CD8 T cells.

PLoS ONE, 2010
During an immune response T cells enter memory fate determination, a program that divides them into two main populations: effector memory and central memory T cells. Since in many systems protection appears to be preferentially mediated by T cells of the
Gonzalo Almanza, Antonio Fernandez, Stefano Volinia, Xochitl Cortez-Gonzalez, Carlo M Croce, Maurizio Zanetti   +5 more
doaj   +3 more sources

Low-dose controlled release of mTOR inhibitors maintains T cell plasticity and promotes central memory T cells. [PDF]

J Control Release, 2017
An important goal for improving vaccine and immunotherapy technologies is the ability to provide further control over the specific phenotypes of T cells arising from these agents. Along these lines, frequent administration of rapamycin (Rapa), a small molecule inhibitor of the mammalian target of rapamycin (mTOR), exhibits a striking ability to ...
Gammon JM, Gosselin EA, Tostanoski LH, Chiu YC, Zeng X, Zeng Q, Jewell CM.   +6 more
europepmc   +3 more sources