Results 11 to 20 of about 1,566,141 (255)

Microglia lactylation in relation to central nervous system diseases [PDF]

Neural Regeneration Research
The development of neurodegenerative diseases is closely related to the disruption of central nervous system homeostasis. Microglia, as innate immune cells, play important roles in the maintenance of central nervous system homeostasis, injury response ...
Dong, Jianhong, Fan, Ziwei, Jia, Mengxian, Mo, Nan, Tong, Lily, Wang, Ying, Yang, Hui, Yue, Juanqing   +7 more
core   +4 more sources

Lactylation and Central Nervous System Diseases [PDF]

Brain Sciences
As the final product of glycolysis, lactate serves as an energy substrate, metabolite, and signaling molecule in various diseases and mediates lactylation, an epigenetic modification that occurs under both physiological and pathological conditions ...
Ye Chen, Dongqiong Xiao, Xihong Li
doaj   +2 more sources

Role of CD36 in central nervous system diseases [PDF]

Neural Regeneration Research
CD36 is a highly glycosylated integral membrane protein that belongs to the scavenger receptor class B family and regulates the pathological progress of metabolic diseases.
Min Feng, Qiang Zhou, Huimin Xie, Chang Liu, Mengru Zheng, Shuyu Zhang, Songlin Zhou, Jian Zhao   +7 more
doaj   +2 more sources

Role of Exosomes in Central Nervous System Diseases [PDF]

Frontiers in Molecular Neuroscience, 2019
There are many types of intercellular communication, and extracellular vesicles are one of the important forms of this. They are released by a variety of cell types, are heterogeneous, and can roughly be divided into microvesicles and exosomes according to their occurrence and function.
Wanying Liu, Wanying Liu, Wanying Liu, Xiaodan Bai, Xiaodan Bai, Xiaodan Bai, Ao Zhang, Juanjuan Huang, Juanjuan Huang, Juanjuan Huang, Shixin Xu, Shixin Xu, Junping Zhang   +12 more
openaire   +5 more sources

Mitochondrion-based organellar therapies for central nervous system diseases [PDF]

Cell Communication and Signaling
As most traditional drugs used to treat central nervous system (CNS) diseases have a single therapeutic target, many of them cannot treat complex diseases or diseases whose mechanism is unknown and cannot effectively reverse the root changes underlying ...
Mengke Zhao, Jiayi Wang, Shuaiyu Zhu, Meina Wang, Chong Chen, Liang Wang, Jing Liu   +6 more
doaj   +2 more sources

Neurosurgical gene therapy for central nervous system diseases [PDF]

Neurotherapeutics
Viral vector mediated gene therapies for neurodegenerative and neurodevelopmental conditions that require neurosurgical administration continue to expand.
Ruchit V. Patel, Pranav Nanda, R. Mark Richardson   +2 more
doaj   +2 more sources

Understanding Childhood Neuroimmune Diseases of the Central Nervous System [PDF]

Frontiers in Pediatrics, 2019
Immune-mediated diseases of the central nervous system (CNS) in childhood are a heterogeneous group of rare conditions sharing the inflammatory involvement of the CNS.
Farello G, Matricardi S, Savasta S, Verrotti A   +3 more
core   +3 more sources

Copper homeostasis and cuproptosis in central nervous system diseases [PDF]

Cell Death and Disease
Copper (Cu), an indispensable micronutrient for the sustenance of living organisms, contributes significantly to a vast array of fundamental metabolic processes.
Zhipeng Zhu, Min Song, Jianxun Ren, Lirong Liang, Guohua Mao, Min Chen   +5 more
doaj   +2 more sources

Extracellular particles: emerging insights into central nervous system diseases [PDF]

Journal of Nanobiotechnology
Extracellular particles (EPs), including extracellular vesicles (EVs) and non-vesicular extracellular particles (NVEPs), are multimolecular biomaterials released by cells that play a crucial role in intercellular communication.
Shenyuan Chen, Qinghua Bao, Wenrong Xu, Xiao Zhai   +3 more
doaj   +2 more sources

Piezo1: the key regulators in central nervous system diseases [PDF]

Frontiers in Cellular Neuroscience
The occurrence and development of central nervous system (CNS) diseases is a multi-factor and multi-gene pathological process, and their diagnosis and treatment have always posed a serious challenge in the medical field. Therefore, exploring the relevant
Yi Xu, Yuheng Wang, Yanling Yang, Xiaowei Fang, Lidong Wu, Jialing Hu, Jin Li, Shuchong Mei   +7 more
doaj   +2 more sources