Results 31 to 40 of about 1,566,141 (255)

Evaluating the efficiency of a nomogram based on the data of neurosurgical intensive care unit patients to predict pulmonary infection of multidrug-resistant Acinetobacter baumannii

Frontiers in Cellular and Infection Microbiology, 2023
BackgroundPulmonary infection caused by multidrug-resistant Acinetobacter baumannii (MDR-AB) is a common and serious complication after brain injury. There are no definitive methods for its prediction and it is usually accompanied by a poor prognosis ...
Di Wu, Di Wu, Zhuang Sha, Zhuang Sha, Yibing Fan, Yibing Fan, Jiangyuan Yuan, Jiangyuan Yuan, Weiwei Jiang, Weiwei Jiang, Mingqi Liu, Mingqi Liu, Meng Nie, Meng Nie, Chenrui Wu, Chenrui Wu, Tao Liu, Tao Liu, Yupeng Chen, Yupeng Chen, Jiancheng Feng, Jiancheng Feng, Shiying Dong, Shiying Dong, Jin Li, Jian Sun, Jian Sun, Chongjie Pang, Rongcai Jiang, Rongcai Jiang   +29 more
doaj   +1 more source

PPARα Modulation-Based Therapy in Central Nervous System Diseases

Life, 2021
The burden of neurodegenerative diseases in the central nervous system (CNS) is increasing globally. There are various risk factors for the development and progression of CNS diseases, such as inflammatory responses and metabolic derangements.
Deokho Lee, Yohei Tomita, William Allen, Kazuo Tsubota, Kazuno Negishi, Toshihide Kurihara   +5 more
doaj   +1 more source

Brainstem syndrome at onset is related to an early MS diagnosis in Peru: A national referral center cohort

Heliyon, 2021
Background: MS is unpredictable regarding clinical symptoms; however, certain symptoms represent the preferred localization of white matter lesions such as brainstem, spinal cord; or optic nerve.
César Caparó-Zamalloa, Sheila Castro-Suarez, Jaqueline Cortez-Escalante, Wilfor Aguirre-Quispe, Erik Guevara-Silva, Victor Osorio-Marcatinco, María Meza-Vega   +6 more
doaj  

Novel Advancements in Three-Dimensional Neural Tissue Engineering and Regenerative Medicine [PDF]

Neural Regen. Res. 2015;10(3):352-4, 2015
Neurological diseases and injuries present some of the greatest challenges in modern medicine, often causing irreversible and lifelong burdens in the people whom they afflict. These diagnoses have devastating consequences on millions of people each year, and yet there are currently no therapies or interventions that can repair the structure of neural ...
arxiv   +1 more source

Elevated peripheral levels of receptor-interacting protein kinase 1 (RIPK1) and IL-8 as biomarkers of human amyotrophic lateral sclerosis

Signal Transduction and Targeted Therapy, 2023
Amyotrophic lateral sclerosis (ALS) is a devastating fatal neurodegenerative disease with no cure. Receptor-interacting protein kinase 1 (RIPK1) has been proposed to mediate pathogenesis of ALS.
Jun Wei, Min Li, Zhi Ye, Xinqian Hu, Xiaoyan He, Jia Wang, Gaofeng Chen, Chengyu Zou, Daichao Xu, Hongbing Zhang, Junying Yuan, Yunhong Zha   +11 more
doaj   +1 more source

Emerging Roles of Signal Transduction Pathways in Neurodegenerative Diseases. Hunting New Possible Therapeutic Molecular Targets [PDF]

, 2023
Illnesses following the degeneration of the nervous system can occur due to aging or genetic mutations and represent a clinical concern. In neurodegenerative diseases, loss of neuronal structure and functions mainly causes cognitive impairment ...
Lo Vasco VR
core   +1 more source

Matrix metalloproteinases as new targets in Alzheimer's disease: Opportunities and Challenges [PDF]

Journal of Medicinal Chemistry, American Chemical Society, 2020, 2021
Although matrix metalloproteinases (MMPs) are implicated in the regulation of numerous physiological processes, evidences of their pathological roles have also been obtained in the last decades, making MMPs attractive therapeutic targets for several diseases.
arxiv  

Review of Human Coronaviruses and Other Respiratory Viruses and their Neurological Impact on the Central Nervous System [PDF]

, 2020
Comprehensive reporting shows that some pathogens, including COVID-19, influenza A and SARS-CoV have sometimes caused pandemics and were linked to more serious diseases and death.
Haider, Monica, Thomas, M.D., Haider
core  

Spatial and temporal heterogeneity of mouse and human microglia at single-cell resolution [PDF]

, 2019
Microglia have critical roles not only in neural development and homeostasis, but also in neurodegenerative and neuroinflammatory diseases of the central nervous system(1-4).
Amann, L., Böttcher, C., Coenen, V., Gold, R., Grün, D., Kunz, P., Masuda, T., Michel, A., Nessler, S., Priller, J., Prinz, M., Reinacher, P., Sagar, S., Sankowski, R., Scheiwe, C., Stadelmann, C., Staszewski, O., Sure, U., van Loo, G.   +18 more
core   +1 more source

Glucose metabolism: A link between traumatic brain injury and Alzheimer’s disease

Chinese Journal of Traumatology, 2021
Traumatic brain injury (TBI), a growing public health problem, is a leading cause of death and disability worldwide, although its prevention measures and clinical cares are substantially improved.
Xiao-Jian Xu, Meng-Shi Yang, Bin Zhang, Fei Niu, Jin-Qian Dong, Bai-Yun Liu   +5 more
doaj