Results 91 to 100 of about 19,940 (252)

Centrioles Regulate Centrosome Size by Controlling the Rate of Cnn Incorporation into the PCM [PDF]

, 2010
SummaryBackgroundCentrosomes are major microtubule organizing centers in animal cells, and they comprise a pair of centrioles surrounded by an amorphous pericentriolar material (PCM). Centrosome size is tightly regulated during the cell cycle, and it has
Brunk, Kathrin, Conduit, Paul T., Dix, Carly I., Dobbelaere, Jeroen, Lucas, Eliana P., Raff, Jordan W.   +5 more
core   +1 more source

TENT5C functions as a corepressor in the ligand‐bound glucocorticoid receptor and estrogen receptor α complexes

The FEBS Journal, EarlyView.
TENT5C is a suppressor of ERα and GR transcriptional activation. A specific LXXLL motif in TENT5C, absent in the other members of the TENT5 subfamily, mediates a stable interaction with the Ligand Binding Domain of ERα but not with that of GR.
Yin Li, Lalith Perera, Rebecca S. He, Marine Baptissart, Robert M. Petrovich, Marcos Morgan   +5 more
wiley   +1 more source

PPP1R35 is a novel centrosomal protein that regulates centriole length in concert with the microcephaly protein RTTN

eLife, 2018
Centrosome structure, function, and number are finely regulated at the cellular level to ensure normal mammalian development. Here, we characterize PPP1R35 as a novel bona fide centrosomal protein and demonstrate that it is critical for centriole ...
Andrew Michael Sydor, Etienne Coyaud, Cristina Rovelli, Estelle Laurent, Helen Liu, Brian Raught, Vito Mennella   +6 more
doaj   +1 more source

Patterns of selection against centrosome amplification in human cell lines.

PLoS Computational Biology, 2021
The presence of extra centrioles, termed centrosome amplification, is a hallmark of cancer. The distribution of centriole numbers within a cancer cell population appears to be at an equilibrium maintained by centriole overproduction and selection ...
Marco António Dias Louro, Mónica Bettencourt-Dias, Claudia Bank   +2 more
doaj   +1 more source

Role for polo-like kinase 4 in mediation of cytokinesis. [PDF]

, 2019
The mitotic protein polo-like kinase 4 (PLK4) plays a critical role in centrosome duplication for cell division. By using immunofluorescence, we confirm that PLK4 is localized to centrosomes.
Brugge, Joan S, Davenport, Simon, Guzman, Roberta, Mak, Tak W, Nolan, Garry P, O'Brien, Neil, Palazzolo, Michael, Press, Michael F, Slamon, Dennis J, Xie, Bin, Zhou, Yu   +10 more
core  

Common themes in centriole and centrosome movements. [PDF]

, 2013
addresses: School of Life Sciences, Oxford Brookes University, Gipsy Lane, Oxford, OX3 0BP, UK.Copyright © 2011 Elsevier. NOTICE: this is the author’s version of a work that was accepted for publication in Trends in Cell Biology.
Allen, Basto, Beisson, Boisvieux-Ulrich, Boisvieux-Ulrich, Boisvieux-Ulrich, Bornens, Brugerolle, Burakov, Carreno, Chevrier, Cowan, Cowan, Dammermann, Dawe, Dawe, Dawe, Desai, Dupin, Etienne-Manneville, Etienne-Manneville, Euteneuer, Fan, Feldman, Finetti, Goldstein, Gomes, Gonczy, Gray, Griffiths, Griffiths, Gull, Helen R. Dawe, Higginbotham, Hirota, Hong, Jenkins, Jolly, Jolly, Karsenti, Kemphues, Kim, Klotz, Koonce, Kuhn, Kunda, Kunda, Lemullois, Lemullois, Lin, Ludford-Menting, Magdalena, Mahoney, Malone, Manneville, Moreira-Leite, Nejmeddine, Nigg, Palazzo, Pan, Park, Park, Pegtel, Piel, Piguet, Prigozhina, Raff, Riento, Rios, Robinson, Robinson, Rosenblatt, Roux, Ryser, Salpingidou, Schmoranzer, Scholey, Siegrist, Sonneville, Starr, Stinchcombe, Stinchcombe, Stowers, Sue Vaughan, Tabuse, Tanaka, Thery, Toyoshima, Tsai, Tsai, Tsou, Valente, Vaughan, Walczak, Wiedemann, Woolner, Worman, Wright, Yamashita, Zhang, Zhang, Zhen   +101 more
core   +1 more source

Reminiscent of the pre‐diatom? A hitherto undescribed scaly bolidophyte Lepidoparma frigida gen. et sp. nov. in a new order Lepidoparmales based on morphology, phylogeny, and ecology

Journal of Phycology, EarlyView.
Abstract The class Bolidophyceae, which consists of small phytoplankton distributed worldwide, is the sister group of diatoms. This class has contained only one order, the Parmales, until now. In this study, we established a new order Lepidoparmales Kamakura & S.Sato ord. nov. and a new family Lepidoparmaceae Kamakura & S.Sato fam.
Shiho Kamakura, Kazumasa Yamada, Eldrin D. L. R. Arguelles, Akira Kuwata, Tamotsu Nagumo, Masakazu Takahashi, Ken Sawada, Mutsuo Ichinomiya, Shinya Sato   +8 more
wiley   +1 more source

Cep120 is asymmetrically localized to the daughter centriole and is essential for centriole assembly [PDF]

Journal of Cell Biology, 2010
Centrioles form the core of the centrosome in animal cells and function as basal bodies that nucleate and anchor cilia at the plasma membrane. In this paper, we report that Cep120 (Ccdc100), a protein previously shown to be involved in maintaining the neural progenitor pool in mouse brain, is associated with centriole structure and function.
Tim Stearns, Zhigang Xie, Moe R. Mahjoub
openaire   +3 more sources

Centriole Amplification in Zebrafish Affects Proliferation and Survival but Not Differentiation of Neural Progenitor Cells

Cell Reports, 2015
In animal cells, supernumerary centrosomes, resulting from centriole amplification, cause mitotic aberrations and have been associated with diseases, including microcephaly and cancer.
Edo Dzafic, Paulina J. Strzyz, Michaela Wilsch-Bräuninger, Caren Norden   +3 more
doaj   +1 more source

Rolling ES cells down the Waddington landscape with Oct4 and Sox2

, 2011
Embryonic stem cell (ESC) pluripotency is maintained by core transcriptional circuits whereby critical factors sustain their own expression while preventing the expression of genes required for differentiation. Thomson et al.
Cavalli, G., Iovino, N.
core   +1 more source