Results 51 to 60 of about 20,027 (280)
The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number [PDF]
Open Biology, 2018 Deregulation of centriole duplication has been implicated in cancer and primary microcephaly. Accordingly, it is important to understand how key centriole duplication factors are regulated.
Christian Arquint +4 more
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Current Opinion in Cell Biology, 2009 Centrioles are cylindrical structures found at the core of the mitotic spindle pole, which also act as basal bodies to nucleate the formation of cilia. Centrioles have a complex, ninefold symmetric structure, and reproduce by an intriguing duplication process. The complexity and apparent self-reproduction of centrioles raises the question of how such a
openaire +2 more sources
Asymmetric Centriole Numbers at Spindle Poles Cause Chromosome Missegregation in Cancer
Cell Reports, 2017 Chromosomal instability is a hallmark of cancer and correlates with the presence of extra centrosomes, which originate from centriole overduplication. Overduplicated centrioles lead to the formation of centriole rosettes, which mature into supernumerary ...
Marco R. Cosenza +14 more
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A novel Cep120-dependent mechanism inhibits centriole maturation in quiescent cells [PDF]
, 2018 The two centrioles of the centrosome in quiescent cells are inherently asymmetric structures that differ in age, morphology and function. How these asymmetric properties are established and maintained during quiescence remains unknown. Here, we show that
Betleja, Ewelina +3 more
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Regulation of cilia abundance in multiciliated cells
eLife, 2019 Multiciliated cells (MCC) contain hundreds of motile cilia used to propel fluid over their surface. To template these cilia, each MCC produces between 100-600 centrioles by a process termed centriole amplification.
Rashmi Nanjundappa +6 more
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Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis. [PDF]
, 2012 Centrioles organize the centrosome, and accurate control of their number is critical for the maintenance of genomic integrity. Centrioles duplicate once per cell cycle, and duplication is coordinated by Polo-like kinase 4 (Plk4).
Bettencourt-Dias, Monica +10 more
core +4 more sources
Whole Genome Analysis of the Red-Crowned Crane Provides Insight into Avian Longevity [PDF]
, 2020 The red-crowned crane (Grus japonensis) is an endangered, large-bodied crane native to East Asia. It is a traditional symbol of longevity and its long lifespan has been confirmed both in captivity and in the wild.
Bhak, Jong +14 more
core +1 more source
Centrioles: Duplicating Precariously [PDF]
Current Biology, 2007 To assemble a mitotic spindle and accurately segregate chromosomes to progeny, a cell needs to precisely regulate its centrosome number, a feat largely accomplished through the tight control of centriole duplication. Recent work showing that the overexpression of centriolar proteins can lead to the formation of multiple centrioles in the absence of pre-
openaire +3 more sources
Two-step phosphorylation of Ana2 by Plk4 is required for the sequential loading of Ana2 and Sas6 to initiate procentriole formation. [PDF]
, 2017 The conserved process of centriole duplication requires Plk4 kinase to recruit and promote interactions between Sas6 and Sas5/Ana2/STIL (respective nomenclature of worms/flies/humans).
Abdelaziz, Mohammed +6 more
core +2 more sources
eLife, 2019 Centrioles play critical roles in organizing the assembly of the mitotic spindle and templating the formation of primary cilia. Centriole duplication occurs once per cell cycle and is regulated by Polo-like kinase 4 (PLK4).
Tyler Chistopher Moyer +1 more
doaj +1 more source