Results 61 to 70 of about 18,770 (220)

Mechanisms of HsSAS-6 assembly promoting centriole formation in human cells [PDF]

, 2014
SAS-6 proteins are thought to impart the ninefold symmetry of centrioles, but the mechanisms by which their assembly occurs within cells remain elusive. In this paper, we provide evidence that the N-terminal, coiled-coil, and C-terminal domains of HsSAS ...
Arquint, Azimzadeh, Azimzadeh, Beck, Bettencourt-Dias, Bornens, Bulseco, Carvalho-Santos, Cavalier-Smith, Chen, Chrétien, Cizmecioglu, Debora Keller, Dickson, Dippell, Dzhindzhev, Gopalakrishnan, Guichard, Guichard, Gönczy, Hatch, Haupts, Hoh, Jan Ellenberg, Kim, Kitagawa, Kleylein-Sohn, Kuriyama, Lau, Lawo, Leidel, Lettman, Lin, Lukinavičius, Maeder, Malte Wachsmuth, Marshall, Mennella, Meritxell Orpinell, Middendorp, Nakazawa, Nicolas Olivier, Nigg, Olivier, Olivier, Pierre Gönczy, Puklowski, Robert Mahen, Romain Wyss, Schmidt, Sonnen, Stevens, Strnad, Strnad, Strnad, Suliana Manley, van Breugel, Virginie Hachet, Vladar, Vulprecht, Wachsmuth   +60 more
core   +3 more sources

Recombinant Monoclonal Antibodies for Detecting the Tubulin Post‐Translational Modifications Glutamylation and Lysine‐40 Acetylation

Cytoskeleton, EarlyView.
ABSTRACT Post‐translational modifications (PTMs) to tubulin subunits in microtubule filaments are thought to comprise a component of the tubulin code that specifies microtubule functions in cell physiology and animal development. Acetylation of Lysine‐40 (K40) on α‐tubulin (αTub‐K40ac) and glutamylation of both α‐ and β‐tubulin are two tubulin PTMs of ...
Lynne Blasius, Ezekiel C. Thomas, Erik H. Collet, Erin Jenson, Chad G. Pearson, Ryoma Ohi, Kristen J. Verhey   +6 more
wiley   +1 more source

Dynamics of centriole amplification in centrosome-depleted brain multiciliated progenitors

Scientific Reports, 2019
Reproductive and respiratory organs, along with brain ventricles, are lined by multiciliated epithelial cells (MCC) that generate cilia-powered fluid flows.
Olivier Mercey, Adel Al Jord, Philippe Rostaing, Alexia Mahuzier, Aurélien Fortoul, Amélie-Rose Boudjema, Marion Faucourt, Nathalie Spassky, Alice Meunier   +8 more
doaj   +1 more source

PLK4 promotes centriole duplication by phosphorylating STIL to link the procentriole cartwheel to the microtubule wall

eLife, 2019
Centrioles play critical roles in organizing the assembly of the mitotic spindle and templating the formation of primary cilia. Centriole duplication occurs once per cell cycle and is regulated by Polo-like kinase 4 (PLK4).
Tyler Chistopher Moyer, Andrew Jon Holland   +1 more
doaj   +1 more source

Intercellular Migration of Centrioles in the Germarium of \u3cem\u3eDrosophila melanogaster\u3c/em\u3e. An Electron Microscopic Study [PDF]

, 1970
A cluster of centrioles has been found in the early Drosophila oocyte. Since the oocyte is connected to 15 nurse cells by a system of intercellular bridges or ring canals, the possibility that the cluster of centrioles arose in the germarium from an ...
Mahowald, Anthony P., Strassheim, Joan M.   +1 more
core   +1 more source

CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base [PDF]

, 2014
The transition zone (TZ) is a specialized compartment found at the base of cilia, adjacent to the centriole distal end, where axonemal microtubules (MTs) are heavily cross-linked to the surrounding membrane to form a barrier that gates the ciliary ...
Amack, Jeffrey D., Asara, John M., Goll, Mary G., Macaluso, Frank P., Perumal, Geoffrey S., Soni, Rajesh, Tay, Hwee Goon, Tsou, Meng-Fu Bryan, Wang, Won-Jing   +8 more
core   +1 more source

Titin Is Present in the Elastic Tethers That Connect Separating Anaphase Chromosomes in Crane‐Fly Spermatocytes

Cytoskeleton, EarlyView.
ABSTRACT Elastic tethers connect telomeres of separating chromosomes in anaphase of animal cells. Immunofluorescence staining of titin in crane‐fly spermatocytes, using 4 different antibodies, shows that the giant elastic protein titin seems to be a component of mitotic tethers: titin “strands” extend between separating chromosomes, connecting their ...
Demetra Economopoulos, Maral Janan, Martina Krüger, Aavo‐Valdur Mikelsaar, Arthur Forer, Rose Sheykhani   +5 more
wiley   +1 more source

The Role of Sperm Centrioles in Human Reproduction – The Known and the Unknown

Frontiers in Cell and Developmental Biology, 2019
Each human spermatozoon contains two remodeled centrioles that it contributes to the zygote. There, the centrioles reconstitute a centrosome that assembles the sperm aster and participate in pronuclei migration and cleavage. Thus, centriole abnormalities
Tomer Avidor-Reiss, Tomer Avidor-Reiss, Matthew Mazur, Matthew Mazur, Emily L. Fishman, Puneet Sindhwani, Puneet Sindhwani   +6 more
doaj   +1 more source

SnapShot: Centriole Biogenesis

Cell, 2009
SPD2 (Ce, Dm)/CEP192 (Hs)No centriole duplication (Ce);
Bettencourt-Dias, Mónica, Glover, David M.   +1 more
openaire   +3 more sources

Co-translational protein targeting facilitates centrosomal recruitment of PCNT during centrosome maturation in vertebrates. [PDF]

, 2017
As microtubule-organizing centers of animal cells, centrosomes guide the formation of the bipolar spindle that segregates chromosomes during mitosis.
Antkowiak, Mark, Brust-Mascher, Ingrid, Castro, Noemi M, Cheung, Lee, Christensen, Lana N, Huang, Bo, Jao, Li-En, Jiang, Xueer, Mahe, Karan, Ou, Tingyoung, Sepulveda, Guadalupe, Yoon, Daniel   +11 more
core   +2 more sources