Cep63 and cep152 cooperate to ensure centriole duplication. [PDF]
PLoS ONE, 2013 Centrosomes consist of two centrioles embedded in pericentriolar material and function as the main microtubule organising centres in dividing animal cells.
Nicola J Brown +4 more
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Role of Polo-like Kinases Plk1 and Plk4 in the Initiation of Centriole Duplication—Impact on Cancer [PDF]
Cells, 2022 Centrosomes nucleate and anchor microtubules and therefore play major roles in spindle formation and chromosome segregation during mitosis. Duplication of the centrosome occurs, similar to DNA, only once during the cell cycle.
Ingrid Hoffmann
doaj +4 more sources
Interactions of N- and C-terminal parts of Ana1 permitting centriole duplication but not elongation [PDF]
Open BiologyThe conserved process of centriole duplication requires the establishment of a Sas6-centred cartwheel initiated by Plk4’s phosphorylation of Ana1/STIL.
Agota Nagy +5 more
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The E2F-DP1 Transcription Factor Complex Regulates Centriole Duplication in Caenorhabditis elegans [PDF]
G3: Genes, Genomes, Genetics, 2016 Centrioles play critical roles in the organization of microtubule-based structures, from the mitotic spindle to cilia and flagella. In order to properly execute their various functions, centrioles are subjected to stringent copy number control.
Jacqueline G. Miller +4 more
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Talpid3-binding centrosomal protein Cep120 is required for centriole duplication and proliferation of cerebellar granule neuron progenitors. [PDF]
PLoS ONE, 2014 Granule neuron progenitors (GNPs) are the most abundant neuronal type in the cerebellum. GNP proliferation and thus cerebellar development require Sonic hedgehog (Shh) secreted from Purkinje cells.
Chuanqing Wu +6 more
doaj +3 more sources
Centriole Duplication at the Crossroads of Cell Cycle Control and Oncogenesis [PDF]
CellsCentriole duplication is a vital process for cellular organisation and function, underpinning essential activities such as cell division, microtubule organisation and ciliogenesis.
Claude Prigent
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eLife, 2015 Primary microcephaly (MCPH) associated proteins CDK5RAP2, CEP152, WDR62 and CEP63 colocalize at the centrosome. We found that they interact to promote centriole duplication and form a hierarchy in which each is required to localize another to the ...
Andrew Kodani +13 more
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The dimeric Golgi protein Gorab binds to Sas6 as a monomer to mediate centriole duplication [PDF]
eLife, 2021 The duplication and ninefold symmetry of the Drosophila centriole requires that the cartwheel molecule, Sas6, physically associates with Gorab, a trans-Golgi component. How Gorab achieves these disparate associations is unclear.
Agnieszka Fatalska +8 more
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PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential. [PDF]
Cytoskeleton (Hoboken)ABSTRACT Centrosomes catalyze the assembly of a microtubule‐based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo‐Like Kinase 4 (PLK4), the master regulator that controls the duplication of the centriolar core to ensure the correct balance of two centrosomes per dividing ...
Hamzah M, Meitinger F, Ohta M.
europepmc +2 more sources
Polo-like kinase 2-dependent phosphorylation of NPM/B23 on serine 4 triggers centriole duplication. [PDF]
PLoS ONE, 2010 Duplication of the centrosome is well controlled during faithful cell division while deregulation of this process leads to supernumary centrosomes, chromosome missegregation and aneuploidy, a hallmark of many cancer cells.
Annekatrin Krause, Ingrid Hoffmann
doaj +3 more sources