Results 1 to 10 of about 273,445 (144)
Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication
Cell Reports, 2018 Summary: The protein deacetylase SIRT1 (Sirtuin 1) regulates many cellular processes, including cell-cycle progression, DNA damage response, and metabolism. Although the centrosome is a key regulator of cell-cycle progression and genome stability, little
Hongbo Ling +4 more
doaj +4 more sources
Role of Polo-like Kinases Plk1 and Plk4 in the Initiation of Centriole Duplication—Impact on Cancer
Cells, 2022 Centrosomes nucleate and anchor microtubules and therefore play major roles in spindle formation and chromosome segregation during mitosis. Duplication of the centrosome occurs, similar to DNA, only once during the cell cycle.
Ingrid Hoffmann
doaj +2 more sources
Interactions of N- and C-terminal parts of Ana1 permitting centriole duplication but not elongation
Open BiologyThe conserved process of centriole duplication requires the establishment of a Sas6-centred cartwheel initiated by Plk4’s phosphorylation of Ana1/STIL.
Agota Nagy +5 more
doaj +3 more sources
Spermatocytes have the capacity to segregate chromosomes despite centriole duplication failure
EMBO ReportsCentrosomes are the canonical microtubule organizing centers (MTOCs) of most mammalian cells, including spermatocytes. Centrosomes comprise a centriole pair within a structurally ordered and dynamic pericentriolar matrix (PCM).
Marnie W Skinner +10 more
doaj +2 more sources
Centriole Duplication at the Crossroads of Cell Cycle Control and Oncogenesis
CellsCentriole duplication is a vital process for cellular organisation and function, underpinning essential activities such as cell division, microtubule organisation and ciliogenesis.
Claude Prigent
doaj +2 more sources
The dimeric Golgi protein Gorab binds to Sas6 as a monomer to mediate centriole duplication
eLife, 2021 The duplication and ninefold symmetry of the Drosophila centriole requires that the cartwheel molecule, Sas6, physically associates with Gorab, a trans-Golgi component. How Gorab achieves these disparate associations is unclear.
Agnieszka Fatalska +8 more
doaj +2 more sources
Self-organization of Plk4 regulates symmetry breaking in centriole duplication
Nature Communications, 2019 During centriole duplication, Plk4 regulates formation of a single daughter centriole adjacent to the mother centriole, but the mechanism is unclear. Here, the authors show that Plk4 can undergo liquid–liquid phase separation and that the condensation ...
Shohei Yamamoto, Daiju Kitagawa
doaj +2 more sources
eLife, 2019 Centrioles play critical roles in organizing the assembly of the mitotic spindle and templating the formation of primary cilia. Centriole duplication occurs once per cell cycle and is regulated by Polo-like kinase 4 (PLK4).
Tyler Chistopher Moyer +1 more
doaj +2 more sources
eLife, 2020 Asymmetrically dividing stem cells often show asymmetric behavior of the mother versus daughter centrosomes, whereby the self-renewing stem cell selectively inherits the mother or daughter centrosome. Although the asymmetric centrosome behavior is widely
Cuie Chen, Yukiko M Yamashita
doaj +2 more sources
Open Biology, 2022 Centrosomes are important organizers of microtubules within animal cells. They comprise a pair of centrioles surrounded by the pericentriolar material, which nucleates and organizes the microtubules.
Neil H. J. Cunningham +2 more
doaj +1 more source