Results 11 to 20 of about 273,445 (144)
Cep63 and cep152 cooperate to ensure centriole duplication. [PDF]
PLoS ONE, 2013 Centrosomes consist of two centrioles embedded in pericentriolar material and function as the main microtubule organising centres in dividing animal cells.
Nicola J Brown +4 more
doaj +7 more sources
Cep57 and Cep57L1 maintain centriole engagement in interphase to ensure centriole duplication cycle
Journal of Cell Biology, 2021 Ito et al. revealed that centrosomal proteins Cep57 and Cep57L1 cooperatively maintain centriole engagement during interphase in human cells. Codepletion of Cep57 and Cep57L1 induces precocious centriole disengagement in interphase, which results in ...
Kei Ito +6 more
semanticscholar +3 more sources
Promotion and Suppression of Centriole Duplication Are Catalytically Coupled through PLK4 to Ensure Centriole Homeostasis [PDF]
Cell Reports, 2016 PLK4 is the major kinase driving centriole duplication. Duplication occurs only once per cell cycle, forming one new (or daughter) centriole that is tightly engaged to the preexisting (or mother) centriole.
Minhee Kim +5 more
doaj +3 more sources
Cell Reports, 2014 Vertebrate centrioles lose their geometric scaffold, the cartwheel, during mitosis, concurrently with gaining the ability to recruit the pericentriolar material (PCM) and thereby function as the centrosome.
Denisse Izquierdo +3 more
doaj +3 more sources
CCHCR1-astrin interaction promotes centriole duplication through recruitment of CEP72
BMC Biology, 2022 Background The centrosome is one of the most important non-membranous organelles regulating microtubule organization and progression of cell mitosis.
Zhenguang Ying +12 more
semanticscholar +4 more sources
Once and only once: mechanisms of centriole duplication and their deregulation in disease
Nature Reviews Molecular Cell Biology, 2018 E. Nigg, A. Holland
semanticscholar +3 more sources
CDK11(p58) is required for centriole duplication and Plk4 recruitment to mitotic centrosomes. [PDF]
PLoS ONE, 2011 BACKGROUND: CDK11(p58) is a mitotic protein kinase, which has been shown to be required for different mitotic events such as centrosome maturation, chromatid cohesion and cytokinesis.
Nathalie Franck +5 more
doaj +1 more source
The centriole duplication cycle [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014 Centrosomes are the main microtubule-organizing centre of animal cells and are important for many critical cellular and developmental processes from cell polarization to cell division. At the core of the centrosome are centrioles, which recruit pericentriolar material to form the centrosome and act as basal bodies to nucleate formation of cilia and ...
Elif Nur, Fırat-Karalar, Tim, Stearns
openaire +2 more sources
Cell Cycle, 2010 In interphase and mitosis, centrosomes play a major role in the spatial organization of the microtubule network. Alterations in centrosome number and structure are associated with genomic instability and occur in many cancers. Centrosome duplication is controlled by centriole replication.
Andrew J, Holland +2 more
openaire +2 more sources
Communications Biology, 2021 WDR62 is a scaffold protein involved in centriole duplication and spindle assembly during mitosis. Mutations in WDR62 can cause primary microcephaly and premature ovarian insufficiency.
U. Ho +10 more
semanticscholar +2 more sources