Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication [PDF]
Cell Reports, 2018 Summary: The protein deacetylase SIRT1 (Sirtuin 1) regulates many cellular processes, including cell-cycle progression, DNA damage response, and metabolism. Although the centrosome is a key regulator of cell-cycle progression and genome stability, little
Hongbo Ling +4 more
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Promotion and Suppression of Centriole Duplication Are Catalytically Coupled through PLK4 to Ensure Centriole Homeostasis [PDF]
Cell Reports, 2016 PLK4 is the major kinase driving centriole duplication. Duplication occurs only once per cell cycle, forming one new (or daughter) centriole that is tightly engaged to the preexisting (or mother) centriole.
Minhee Kim +5 more
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Cep57 and Cep57L1 maintain centriole engagement in interphase to ensure centriole duplication cycle. [PDF]
J Cell Biol, 2021 Centrioles duplicate in interphase only once per cell cycle. Newly formed centrioles remain associated with their mother centrioles. The two centrioles disengage at the end of mitosis, which licenses centriole duplication in the next cell cycle. Therefore, timely centriole disengagement is critical for the proper centriole duplication cycle.
Ito KK +6 more
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The centriole duplication cycle. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2014 Centrosomes are the main microtubule-organizing centre of animal cells and are important for many critical cellular and developmental processes from cell polarization to cell division. At the core of the centrosome are centrioles, which recruit pericentriolar material to form the centrosome and act as basal bodies to nucleate formation of cilia and ...
Fırat-Karalar EN, Stearns T.
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p53 protects against genome instability following centriole duplication failure. [PDF]
J Cell Biol, 2015 Centriole function has been difficult to study because of a lack of specific tools that allow persistent and reversible centriole depletion. Here we combined gene targeting with an auxin-inducible degradation system to achieve rapid, titratable, and reversible control of Polo-like kinase 4 (Plk4), a master regulator of centriole biogenesis.
Lambrus BG +6 more
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Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells. [PDF]
Commun Biol, 2023 Il Ahn J +19 more
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Self-organization of Plk4 regulates symmetry breaking in centriole duplication [PDF]
Nature Communications, 2019 During centriole duplication, Plk4 regulates formation of a single daughter centriole adjacent to the mother centriole, but the mechanism is unclear. Here, the authors show that Plk4 can undergo liquid–liquid phase separation and that the condensation ...
Shohei Yamamoto, Daiju Kitagawa
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Protein Phosphatase 1 Down Regulates ZYG-1 Levels to Limit Centriole Duplication. [PDF]
PLoS Genetics, 2017 In humans perturbations of centriole number are associated with tumorigenesis and microcephaly, therefore appropriate regulation of centriole duplication is critical. The C.
Nina Peel +5 more
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Alstrom syndrome gene is a stem-cell-specific regulator of centriole duplication in the Drosophila testis [PDF]
eLife, 2020 Asymmetrically dividing stem cells often show asymmetric behavior of the mother versus daughter centrosomes, whereby the self-renewing stem cell selectively inherits the mother or daughter centrosome. Although the asymmetric centrosome behavior is widely
Cuie Chen, Yukiko M Yamashita
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Cell Reports, 2014 Vertebrate centrioles lose their geometric scaffold, the cartwheel, during mitosis, concurrently with gaining the ability to recruit the pericentriolar material (PCM) and thereby function as the centrosome.
Denisse Izquierdo +3 more
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