Results 51 to 60 of about 273,445 (144)
The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries [PDF]
Nature Cell Biology, 2011 Centrosomes are microtubule-organizing centres of animal cells. They influence the morphology of the microtubule cytoskeleton, function as the base for the primary cilium and serve as a nexus for important signalling pathways. At the core of a typical centrosome are two cylindrical microtubule-based structures termed centrioles, which recruit a matrix ...
Nigg, Erich A., Stearns, Tim
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Journal of Cell Science, 2020 Breast cancer gene 1 (BRCA1) contributes to the regulation of centrosome number. We previously identified receptor for activated C kinase 1 (RACK1) as a BRCA1-interacting partner.
Yuki Yoshino +7 more
semanticscholar +2 more sources
Cells, 2020 Centrioles are microtubule-based cellular structures present in most human cells that build centrosomes and cilia. Proliferating cells have only two centrosomes and this number is stringently maintained through the temporally and spatially controlled ...
Catherine Sullenberger +3 more
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CRL4DCAF1 ubiquitin ligase regulates PLK4 protein levels to prevent premature centriole duplication
Life Science AllianceThis study identifies the E3 ubiquitin ligase, CRL4DCAF1, as a new regulator of polo-like kinase 4, PLK4, protein levels in the G2 phase of the cell cycle to prevent premature duplication of centrioles.
Josina Grossmann +4 more
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Centriole duplication and maturation in animal cells
, 1999 Publisher Summary The functional role and structural features of the centriole and the molecular events underlying centriolar duplication and maturation are discussed in the chapter. The published data are reviewed, with emphasis on the centriole of mammalian cells.
Lange, B, Faragher, A, March, P, Gull, K
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Plk4-dependent phosphorylation of STIL is required for centriole duplication
Biology Open, 2015 Duplication of centrioles, namely the formation of a procentriole next to the parental centriole, is regulated by the polo-like kinase Plk4. Only a few other proteins, including STIL (SCL/TAL1 interrupting locus, SIL) and Sas-6, are required for the ...
Anne-Sophie Kratz +3 more
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Tissue specific requirement of Drosophila Rcd4 for centriole duplication and ciliogenesis
Journal of Cell Biology, 2020 Panda et al. find that Rcd4 is required for centriole duplication and ciliogenesis in neurosensory organs but dispensable for spermatogenesis, indicating tissue specific requirements for centriole formation.
P. Panda +8 more
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Polo-like kinase 4: the odd one out of the family
Cell Division, 2010 Polo-like kinase 4 (PLK4) is a unique member of the Polo-like family of kinases that shares little homology with its siblings and has an essential role in centriole duplication.
Bornens Michel, Sillibourne James E
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CEP44 is required for maintaining centriole duplication and spindle integrity
bioRxivIn animal cells, the centrosome, consisting of two centrioles, duplicates only once per cell cycle for bipolar spindle formation. Defective centriole duplication results in abnormal spindle formation and chromosome missegregation, which is closely linked
Donghui Zhang +8 more
semanticscholar +1 more source
Nature Communications, 2019 Centriolar separation is thought to be crucial for centriole duplication, but the mechanism behind separation is poorly understood. Here, using micropatterning, the authors report that actomyosin forces influence the direction, distance, and time of ...
Elisa Vitiello +7 more
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