Results 51 to 60 of about 3,540 (186)

Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication [PDF]

The Journal of Cell Biology, 2008
Centrosome duplication is tightly controlled in coordination with DNA replication. The molecular mechanism of centrosome duplication remains unclear. Previous studies found that a fraction of human proline-directed phosphatase Cdc14B associates with centrosomes. However, Cdc14B's involvement in centrosome cycle control has never been explored. Here, we
Wu, Jun, Cho, Hyekyung P., Rhee, David B., Johnson, Dabney K., Dunlap, John, Liu, Yie, Wang, Yisong   +6 more
openaire   +2 more sources

Centriolar SAS-7 acts upstream of SPD-2 to regulate centriole assembly and pericentriolar material formation

eLife, 2017
The centriole/basal body is a eukaryotic organelle that plays essential roles in cell division and signaling. Among five known core centriole proteins, SPD-2/Cep192 is the first recruited to the site of daughter centriole formation and regulates the ...
Kenji Sugioka, Danielle R Hamill, Joshua B Lowry, Marie E McNeely, Molly Enrick, Alyssa C Richter, Lauren E Kiebler, James R Priess, Bruce Bowerman   +8 more
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A Structural Study of Conserved Centriole Duplication Machinery

, 2019
Centrioles are microtubule-based cylindrical structures that act within organelles responsible for nucleating polarized microtubule networks. Centrioles have an inherent nine-fold radial symmetry with species-dependent dimensions. Despite the fact that centrioles have been described by biologists for over a century, the process by which cells license ...
Lauren K. Slevin
openalex   +3 more sources

Dissociating the Centrosomal Matrix Protein AKAP450 from Centrioles Impairs Centriole Duplication and Cell Cycle Progression [PDF]

Molecular Biology of the Cell, 2003
Centrosomes provide docking sites for regulatory molecules involved in the control of the cell division cycle. The centrosomal matrix contains several proteins, which anchor kinases and phosphatases. The large A-Kinase Anchoring Protein AKAP450 is acting as a scaffolding protein for other components of the cell signaling machinery.
Keryer, G., Witczak, O., Delouvée, A., Kemmner, W., Rouillard, D., Taskén, K., Bornens, M.   +6 more
openaire   +3 more sources

Ab ovo or de novo? Mechanisms of Centriole Duplication [PDF]

Molecules and Cells, 2009
The centrosome, an organelle comprising centrioles and associated pericentriolar material, is the major microtubule organizing center in animal cells. For the cell to form a bipolar mitotic spindle and ensure proper chromosome segregation at the end of each cell cycle, it is paramount that the cell contains two and only two centrosomes.
Jadranka, Loncarek, Alexey, Khodjakov
openaire   +2 more sources

Experimental and Natural Induction of de novo Centriole Formation

Frontiers in Cell and Developmental Biology, 2022
In cycling cells, new centrioles are assembled in the vicinity of pre-existing centrioles. Although this canonical centriole duplication is a tightly regulated process in animal cells, centrioles can also form in the absence of pre-existing centrioles ...
Kasuga Takumi, Daiju Kitagawa
doaj   +1 more source

Integrity of the Pericentriolar Material Is Essential for Maintaining Centriole Association during M Phase. [PDF]

PLoS ONE, 2015
A procentriole is assembled next to the mother centriole during S phase and remains associated until M phase. After functioning as a spindle pole during mitosis, the mother centriole and procentriole are separated at the end of mitosis.
Mi Young Seo, Wonyul Jang, Kunsoo Rhee
doaj   +1 more source

SAS-6 Assembly Templated by the Lumen of Cartwheel-less Centrioles Precedes Centriole Duplication [PDF]

Developmental Cell, 2014
Centrioles are 9-fold symmetric structures duplicating once per cell cycle. Duplication involves self-oligomerization of the centriolar protein SAS-6, but how the 9-fold symmetry is invariantly established remains unclear. Here, we found that SAS-6 assembly can be shaped by preexisting (or mother) centrioles.
Fong, Chii Shyang, Kim, Minhee, Yang, T. Tony, Liao, Jung-Chi, Tsou, Meng-Fu Bryan   +4 more
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STIL is required for centriole duplication in human cells [PDF]

Journal of Cell Science, 2012
Centrioles are key structural elements of centrosomes and primary cilia. In mammals, only a few proteins including PLK4, CPAP (CENPJ), SAS6, CEP192, CEP152 and CEP135 have thus far been identified to be required for centriole duplication. STIL (SCL/TAL1 interrupting locus, also known as SIL) is a centrosomal protein that is essential for mouse and ...
Julia, Vulprecht, Ahuvit, David, Alexandra, Tibelius, Asher, Castiel, Gleb, Konotop, Fengying, Liu, Felix, Bestvater, Marc S, Raab, Hanswalter, Zentgraf, Shai, Izraeli, Alwin, Krämer   +10 more
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With Age Comes Maturity: Biochemical and Structural Transformation of a Human Centriole in the Making

Cells, 2020
Centrioles are microtubule-based cellular structures present in most human cells that build centrosomes and cilia. Proliferating cells have only two centrosomes and this number is stringently maintained through the temporally and spatially controlled ...
Catherine Sullenberger, Alejandra Vasquez-Limeta, Dong Kong, Jadranka Loncarek   +3 more
doaj   +1 more source